Aysel Gülbandılar

In this study, the salts {(Habt)(Hdpc) (3), (Habt)(Hdpc)2 (6), (HMeabt)(Hdpc).H2O (12), (HMeOabt)(Hdpc) (18)} obtained from 2,6-pyridinedicarboxylic acid (H2dpc) and 2-aminobenzothiazole (abt), 2-amino-6-chlorobenzothiazole (Clabt), 2-amino-6-methylbenzothiazole (Meabt), and 2-amino-6-methoxybenzothiazole (MeOabt), and metal complexes of 1 {Fe(III) (Habt)[Fe(dpc)].4H2O (2), Co(II) (Habt)2[Co(dpc)].3H2O (3), Ni(II) (Habt)2[Ni(dpc)].4H2O (4), Cu(II) [Cu(dpc)(abt)(H2O)] (5)}, of 6 {Fe(III) (HClabt)[Fe(dpc)].5H2O (7), Co(II) (HClabt)2[Co(dpc)].H2O (8), Ni(II) (HClabt)2[Ni(dpc)].H2O (9), Cu(II) [Cu(dpc)(Clabt)(H2O)]2 (10), Cu(II) (HClabt)2[Cu(dpc)].H2O (11)}, of 12 {Fe(II) (HMeabt)2[Fe(dpc)].H2O (13), Fe(III) (HMeabt)[Fe(dpc)].5H2O (14), Co(II) (HMeabt)2[Co(dpc)].H2O (15), Ni(II) (HMeabt)2[Ni(dpc)].H2O (16), Cu(II) (HMeabt)2[Cu(dpc)].H2O (17)}, of 18 {Fe(III) (HMeOabt)[Fe(dpc)].2H2O (19), Co(II) (HMeOabt)2[Co(dpc)].4H2O (20), Ni(II) (HMeOabt)2[Ni(dpc)].H2O (21), Cu(II) (HMeOabt)2[Cu(dpc)].H2O (22)} were synthesized by the methods found in the literature. The metal percentages in the structures of the synthesized compounds (2-5, 7-11, 14-17, and 19-22) were compared with those in the literature using Atomic Absorption Spectroscopy (AAS). Furthermore, the antimicrobial properties of all compounds have also been tested against C. albicans (antifungal activity) and E. Coli, P. aeruginosa, B. subtilis, S. aureus, L. monocytogenes, and E. faecalis (antibacterial activity). The results were compared with those obtained using the control compounds Fluconazole and Ketoconazole (antifungal activity) and Vancomycin, Levofloxacin, Cefepime, and Chloramphenicol (antibacterial activity). As a result of activity studies, newly synthesized compounds show activity against bacteria and yeasts. Specifically, compound 9 demonstrated superior activity against all bacteria and yeasts. Compounds Clabt and 18 showed good activity against C. albicans compared to control compounds. In conclusion, it is suggested that all compounds have potential applications in inhibiting bacterial and yeast growth. Consequently, all compounds are proposed to have potential applications in inhibiting bacterial and yeast growth.

In this study, the salt {1, (H2edp)(adsa)}, obtained from 4,4’-ethylenedipyridine (edp) and aniline-2,5-disulfonic acid (H2adsa) and new Ni(II) complex {[Ni2(edp)4(H2O)8](adsa)2.3H2O, 2} were synthesized. The complex was defined by using elemental analysis, AAS, IR, UV-Vis, and magnetic susceptibility techniques. In addition, antimicrobial activities of edp, H2adsa, 1, and 2 against Escherichia coli (ATCC 25922), Enterococcus faecalis (ATCC 29212), Pseudomonas aeruginosa (ATCC 27853), Listeria monocytogenes (ATCC 7644), and Staphylococcus aureus (NRRL-B 767), and Bacillus subtilis bacteria and Candida albicans (F89) yeast were investigated using the microdilution method and compared with existing antibiotics (cefepime, vancomycin, levofloxacin, chloramphenicol, fluconazole, and ketoconazole). As a result of the activity studies, edp for E. coli, edp, H2adsa, and 2 for E. faecalis, edp, H2adsa, 1, and 2 for P. aeruginosa, edp and 2 for L. monocytogenes, H2adsa for S. aureus, edp, H2adsa, and 2 for B. subtilis, and H2adsa for C. albicans have the best activity. As a result, the synthesized compound (2) can be assessed for use in the synthesis of new antibacterial compounds.

This study investigated the antibiotic resistance profiles of Lactic Acid Bacteria (LAB) isolated from traditional brined cheeses produced in Eskişehir, Turkey. The diversity of cheese production techniques and the richness of product types were key factors in selecting Eskişehir as the sampling area for this study. The microbiota of cheeses is significantly influenced by local factors such as milk sources, raw milk processing conditions, and specific fermentation practices. A total of twelve representative cheese samples from different origins and processing methods were analyzed. MALDI-TOF MS was employed for species identification at the LAB level due to its effectiveness and speed. Among the 25 identified isolates, Enterococcus faecium represented 48%, Lactobacillus plantarum 28%, Enterococcus durans 12%, Lactococcus lactis 8%, and Lactococcus garvieae 4%. The antibiotic susceptibility test was performed by the Kirby-Bauer disk diffusion method according to Clinical Laboratory Standards Institute (CLSI) guidelines. High resistance rates were recorded for clindamycin (84%), erythromycin (76%), and rifampicin (72%), while no resistance was recorded against tetracycline and chloramphenicol. These findings highlight the role of LAB as reservoirs of resistance genes, posing a public health risk due to potential horizontal gene transfer to pathogenic bacteria. The study underlines the need for stricter safety assessments in traditional cheeses and regulatory legislation on the use of antibiotics in livestock. Further resistance mechanisms of LAB and their genetic study are recommended, having an important bearing on food safety.

2-Aminobenzothiazole and its derivatives generally have applications in drug discovery, development of diabetes treatments, epilepsy, amyotrophic lateral sclerosis, analgesia, tuberculosis treatment, and viral infections. In this study, Fe(III) (2, 7, 12, 17), Co(II) (3, 8, 13, 18), Ni(II) (4, 9, 14, 19), and Cu(II) (5, 10, 15, 20) complexes of 2-aminobenzothiazole (1), 2-amino-6-chlorobenzothiazole (6), 2-amino-6-methylbenzothiazole (11), and 2-amino-6-methoxybenzothiazole (16), respectively, were synthesized by the method found in the literature. The architectures of the synthesized complex compounds (1-20) were postulated through the application of Atomic Absorption Spectroscopy (AAS). Furthermore, the antimicrobial activities of compounds 1–20 were tested against Candida albicans (antifungal activity) and Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis, Staphylococcus aureus, Listeria monocytogenes, and Enterococcus faecalis (antibacterial activity). The results were compared with those obtained using the control compounds Fluconazole and Ketoconazole (antifungal activity) and Vancomycin, Levofloxacin, Cefepime, and Chloramphenicol (antibacterial activity). As a result of activity studies, synthesized compounds show activity against bacteria and yeasts. The best activity results were observed compounds 6 and 10 in C. albicans yeast, compound 20 in S. aureus bacteria, compound 13 in E. faecalis bacteria, compounds 12, 13, 17, and 20 in B. subtilis bacteria, compounds 5 and 19 in P. aeruginosa bacteria, compounds 1, 4, 6, 9, 17, and 20 in E. coli bacteria, and compounds 5, 6, 8, 17, and 19 in in L. monocytogenes bacteria. In particular, compound 4 for E. Coli, 6, and 10 for C. albicans showed better activity than the control compounds.

Canlılar üzerinde hastalıklara neden olan mikroorganizmaların karşı kullanılanilaçların duyarlılığı gitgide azalmasını nedeniyle bu hastalıklara karşı dirençbgösteren kimyasallara ihtiyaç bulunmaktadır. Bu nedenle, N-(benzotiazol-2-il)benzamit’in (abt) ve 4-kloro-N-(6-sülfamoilbenzotiazol-2-il)benzamit’in (smabt) yeni Fe(II) {[Fe(abt)2(SO4)].H2O (1) ve [Fe(smabt)2(SO4)].H2O (2)} ve Cu(II){[Cu(abt)2(Ac)2].4H2O (3) ve [Cu(smabt)2(Ac)2].4H2O (4)} kompleksleri sentezlendi. 1-4’ün yapıları, element analiz, AAS, IR, molar iletkenlik ve manyetik duyarlılık yöntemleri ile önerildi. Spektroskopik değerlendirmenin bir sonucu olarak, 1-4 bileşiklerinin iyonik olmayan ve tetrahedral geometriye sahip olduğu önerildi. Ayrıca, tüm maddelerin C. albicans (maya), E. faecalis, E. coli, L.monocytogenes, S. aureus, P. aeruginosa ve B. subtilis (bakteri) karşı antimikrobiyal aktiviteler incelendi ve Ketokonazol, Flukonazol, Levofloksasin, Kloramfenikol, Vankomisin ve Sefepim ile karşılaştırıldı. Tüm maddelerin bakterilere veya mayaya karşı antimikrobiyal özellik gösterdiği gözlendi. Başlangıç maddeleri (abt, smabt) ile komplekslerin (1-4) antimikrobiyal aktiviteleri karşılaştırıldığında, S. aureus (4 hariç), E. coli (1 hariç), B. subtilis, E. faecalis, L. monocytogenes bakterileri ve C. albicans mayasında aynı aktivite gözlenmiştir. S. aureus bakterisinde 4 daha az, E. coli bakterisinde 1 daha çok etki göstermiştir. P. aeruginosa bakterisinde ise 1 > 3, smabt > abt, 2, 4 şeklinde etki gözlenmiştir.

Bu çalışmada 4-kloro-3-sülfamoyilbenzoik asit (5) ile 2-amino-X-pikolin’in {X = 3 (6), 4 (7), 5 (8) ve 6 (9)} Cu(II) kompleksleri (1-4) sentezlenmiştir. Sentezlenen bileşiklerin yapıları, AAS, elementel analiz, IR, UV, molar iletkenlik ve manyetik duyarlılık metotları ile aydınlatılmıştır. Sentezlenen ve kullanılan maddelerin Candida albicans mayasına, Staphylococcus aureus, Bacillus subtilis, Enterococcus faecalis, Listeria monocytogenes, Pseudomonas aeruginosa ve Escherichia coli bakterilerine karşı antimikrobiyal aktiviteleri incelenmiştir. Antimikrobiyal aktivite sonuçları Flukonazol, Ketokonazol, Kloramfenikol, Levofloksasin, Vankomisin ve Sefepim ile kıyaslanmıştır. Bileşiklerin en iyi aktivite değerleri S. aureus bakterilerinde 1 ve 2, E. coli bakterisinde 5, P. aeruginoa bakterisinde 7, L. monocytogenes bakterisinde 2, E. faecalis bakterisinde tüm bileşikler, B. subtilis bakterisinde 8 ve C. albicans mayasında 1 gözlenmiştir.

In this study, the new Fe(II) {[Fe(abt)2(SO4)].H2O (1)}, Ni(II) {[Ni(abt)2(Ac)2].4H2O (2)} and Cu(II) {[Cu(abt)2(Ac)2].4H2O (3)} complexes of 4-nitro-N-(6-sulfamoylbenzothiazol-2-yl)benzamide (abt) were synthesized. The structures (1-3) were suggested by elemental analysis, AAS, molar conductivity, and magnetic susceptibility methods. As a consequence of spectroscopic evaluation, it was determined that compounds 1-3 exhibited a non-ionic and tetrahedral conformation. A comprehensive examination was conducted on the susceptibility of all substances to C. albicans (yeast), E. faecalis, E. coli, L. monocytogenes, S. aureus, P. aeruginosa, and B. subtilis (bacteria) were thoroughly investigated. The antimicrobial activities were contrasted with those of Ketoconazole, Fluconazole, Levofloxacin, Chloramphenicol, Vancomycin, and Cefepime. Compounds abt and 2 showed better activity in S. aureus and B. subtilis bacteria, while compounds 1-3 showed the same activity in E. coli and E. faecalis bacteria and C. albicans yeast. Complex 3 showed better activity in L. monocytogenes bacteria.

In this study, the new 4-iodo-N-(6-sulfamoylbenzothiazol-2-yl)benzamide (L3) obtained from 2-amino-6-sulfamoylbenzothiazole (L1) and 4-iodobenzoyl chloride (L2) and Fe(II) {[Fe(L3)2(SO4)].H2O (1)}, Ni(II) {[Ni(L3)2(Ac)2].2H2O (2)} and Cu(II) {[Cu(L3)2(Ac)2].2H2O (3)} complexes were synthesized. The structures were synthesized by elemental analysis for L3 and 1-3, infrared spectroscopy (IR) for L3 and 1-3, nuclear magnetic resonance (NMR) for L3, atomic absorption spectroscopy (AAS), molar conductivity, and magnetic susceptibility methods for 1-3. As a consequence of spectroscopic evaluation, it was determined that compounds 1-3 exhibited a non-ionic and tetrahedral conformation. A comprehensive examination was conducted on the susceptibility of all substances to C. albicans (yeast), L. monocytogenes, E. faecalis, E. coli, P. aeruginosa, S. aureus, and B. subtilis (bacteria) were thoroughly investigated. The antimicrobial activities were contrasted with those of Ketoconazole, Fluconazole, Levofloxacin, Chloramphenicol, Vancomycin, and Cefepime.

2-Amino-5-bromopiridin (ap) ile dipikolinik asitin (H2pka) tuzu {(Hap)(Hpka), 1) ve tuzun metal kompleksleri {(Hap [Fe(pka)2].2H2O (2), (Hap)2[Co(pka)2].4H2O (3), (Hap)2[Ni(pka)2].3H2O (4), (Hap)2[Cu(pka)2].2H2O (5)} sentezlenmiştir. 1-5'in yapıları elementel analiz, NMR, AAS, IR, UV, molar iletkenlik ve manyetik duyarlılık yöntemleri ile önerilmiştir. Spektroskopik analiz sonucunda tüm metal komplekslerinin iyonik ve oktahedral yapıya sahip olduğu görülmüştür. Çalışmada kullanılan ve sentezlenen bileşiklerin Candida albicans (ATCC 14053) mayasına karşı antifungal, Bacillus subtilis, Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853), Enterococcus faecalis (ATCC 29212), Listeria monocytogenes (ATCC 7644) ve Staphylococcus aureus (NRRL-B 767) bakterilerine karşı antibakteriyel aktiviteleri incelenmiştir. Antifungal aktivite sonuçları Ketokonazol ve Flukonazol ile karşılaştırılırken, antibakteriyel aktiviteler Levofloksasin, Vankomisin, Kloramfenikol ve Sefepim ile karşılaştırılmıştır. Aktivite sonuçlarında en iyi değerler C. albicans mayasında 3, E. coli bakterisinde tüm bileşikler, S. aureus bakterisinde 1 ve 2, L. monocytogenes bakterisinde 2, B. subtilis bakterisinde 1, ap, P. aeruginoa bakterisinde 1 ve 2 ve E. faecalis bakterisinde ise tüm bileşiklerde (4 ve 5 hariç) gözlenmiştir.

This study aimed to evaluate the antibacterial efficacy of calcium hydroxide (Ca(OH)₂), Ca(OH)₂ + resveratrol (RV), Ca(OH)₂ + silver nanoparticles(AgNPs), and Ca(OH)₂ + salicylic acid (SA) against Enterococcus faecalis (E. faecalis) using culture methods and field emission scanning electron microscopy (FE-SEM). Fifty-four extracted single-rooted teeth were prepared with standardized internal resorption cavities and inoculated with E. faecalis (ATCC 29212). After 21 days of incubation, baseline bacterial counts were determined. The teeth were randomly assigned to five groups (n = 10) based on the applied medicament. After 14 days of incubation, bacterial counts were reassessed, and two samples from each group were analyzed using FE-SEM. Data were analyzed using one-way ANOVA and Duncan’s test (p < .05). All medicament groups significantly reduced bacterial counts (p < .001), with Ca(OH)₂ + RV, Ca(OH)₂ + AgNPs, and Ca(OH)₂ + SA demonstrating superior antibacterial activity compared to Ca(OH)₂ alone (p < .001). The saline group exhibited the highest bacterial counts (p < .001). Combining Ca(OH)₂ with RV, AgNPs, or SA significantly enhances antibacterial efficacy in internal root resorption cases. These combinations may serve as effective alternatives to Ca(OH)₂ alone in endodontic disinfection. Intracanal medicament application plays a vital role in eliminating microorganisms and enhancing the success of endodontic treatment, particularly in cases of internal root resorption. This study highlights the superior antibacterial efficacy of Ca(OH)₂ combined with RV, AgNPs, or SA against E. faecalis. These findings suggest that incorporating these adjuncts into intracanal medicaments may improve disinfection outcomes, offering potential clinical benefits in managing internal root resorption cases.