Lin-Sen Feng

The general public may lack adequate cancer health education, resulting in low cancer awareness and insufficient understanding of the importance of cancer

Background Physical activity (PA) is a crucial component in the management of cancer survivors. In recent years, a number of quantitative studies on PA among patients with haematological malignancies (HMs) have emerged both domestically and internationally. Methods The literature search was conducted in the PubMed database. The included study types mainly consist of observational studies, interventional studies, case-control studies, meta-analyses and clinical translational studies. The search period was set from 1 January 2022 to 31 May 2025. Results 11 related search strategies were created. After applying the screening process, a total of 80 literatures were ultimately included in the review and cited. PA may be closely associated with the risk of developing certain types of HM, but current evidence remains controversial. PA offers benefits for patients with various HMs, including multiple myeloma, lymphoma, acute leukaemia and myeloproliferative neoplasms. However, due to factors such as reduced gait speed, grip strength, weight loss, exhaustion and weakness, these patients often experience limitations in PA, motor function and quality of life. While the role and frequency of PA can be debated in some subtypes of HM, interventions promoting PA are generally essential for most survivors. Conclusions Haematological specialists should monitor PA in patients with HM and implement timely, effective and safe interventions within a multidisciplinary framework to support sustained PA engagement.

Objective: Fear of medical imaging radiation (FOMIR) may influence disease screening willingness; however, no validated tool currently exists to assess FOMIR. This study aimed to develop and validate the Fear of Medical Imaging Radiation Scale (FOMIRS) and explore its psychological mechanisms. Methods: Based on classical test theory, the FOMIRS was developed through semi-structured interviews, grounded theory, and Delphi consultation. A cross-sectional survey with 1509 participants was conducted in Yunnan Province from September to December 2024. Psychometric properties were evaluated using construct validity, convergent validity, discriminant validity, criterion-related validity, content validity, and internal consistency. ROC curve analysis was used to determine the critical thresholds. Logistic regression analysis, network analysis, and structural equation modeling were employed to examine the relationships between the FOMIRS and related variables. Results: The FOMIRS consisted of 18 items organized into a two-dimensional structure. It demonstrated good model fit (Goodness-of-fit index = 0.909, Comparative fit index = 0.949), convergent validity (AVE > 0.45, CR > 0.80), discriminant validity (HTMT = 0.574), criterion-related validity (γ = 0.441), and content validity (S-CVI = 0.889). The FOMIRS also showed excellent internal consistency (Cronbach’s α = 0.926 and McDonald’s ω = 0.935). Cost-induced refusal of imaging examinations, cancer screening willingness, online learning, imaging radiation cognition, and fear of cancer were identified as influencing factors of FOMIR (p < 0.05). FOMIR serves as a core node in the network, and imaging radiation cognition may affect cancer screening willingness through this mechanism (p < 0.05). Conclusion: FOMIRS accurately measures individual FOMIR levels. It captures the psychological characteristics and behavioral tendencies associated with FOMIR and indicates potential mechanisms. Critical relevance statement: We developed the Fear of Medical Imaging Radiation Scale (FOMIRS), a psychometric tool measuring individuals’ fear of medical imaging radiation (FOMIR), demonstrating good reliability, validity, and practical application potential. Key Points: Evaluating individuals’ FOMIR improves compliance with imaging exams and reduces related cognitive biases. FOMIRS is a reliable and valid tool for measuring FOMIR levels, capturing psychological and behavioral traits, and revealing interactions with external features. FOMIR is a complex phenomenon involving psychological traits, behavioral tendencies, and cognitive biases that affect people’s willingness to undergo cancer screening. Graphical

Background The treatment of relapsed/refractory T cell acute lymphoblastic leukemia (R/R T-ALL) is a significant challenge in hematologic oncology, and no standard salvage treatment plan exists. Both Chinese and international clinical guidelines recommend combination chemotherapy including venetoclax. Methods Efficacy and safety of venetoclax, azacitidine, homoharringtonine, cytarabine, and aclarubicin (VA-HAA) combination therapy were retrospectively analyzed in 3 patients with R/R T-ALL at the Department of Hematology, 920th Hospital of the Joint Logistics Support Force, Chinese People’s Liberation Army. Results The chemotherapy resulted in CR/CRi with negative flow MRD in all 3 patients. Quantitative negative conversion was achieved in 2 patients with fusion genes, and the frequency of monoclonal TCR gene rearrangements was significantly reduced in 1 patient. All patients received stem cell rescue after the chemotherapy. Hematologic toxicity may be manageable, with a median of 24 days for complete recovery of neutrophils (ANC) and 36 days for partial recovery of platelets. There were no major bleeding events or chemotherapy-related deaths. Conclusion VA-HAA may be an effective and safe salvage treatment for R/R T-ALL, and prospective clinical trials are needed to verify its specific clinical efficacy.

Lack of health knowledge can be a main cause of barriers to early diagnosis and treatment, and it can also highlight the deficiencies in health education. Therefore, it is essential to understand the health knowledge needs of individuals and the related influencing factors in order to improve health education models. A total of 935 administrative staff (AS) were selected as study participants by convenience sampling in Yuxi City, China. An electronic questionnaire, comprising four parts—Health Knowledge Needs, Sociodemographic Characteristics, Health Psychology and Behavior, and Self-Reported Medical History—were used to collect data. Statistical analysis was conducted using an internal consistency test, Kruskal–Wallis test, principal component analysis, hierarchical clustering analysis, and binary logistic regression analysis, performed with SPSS version 19.0. The Health Knowledge Needs Questionnaire had a Cronbach’s α of 0.883 and a Guttman Split-Half coefficient of 0.907. The need rates for health knowledge exceeding 30% are as follows: Traditional Chinese Medicine, Hypertension, Weight Management, Dietary Nutrition and Food Hygiene, Hyperlipidemia, Gastrointestinal Diseases, Heart Diseases, and First Aid. Health knowledge needs were summarized into six dimensions: “Diseases with Low Health Knowledge Needs”, “Maternal and Child Health Care and Thyroid Diseases”, “Cardiovascular and Cerebrovascular Diseases and Malignancies”, “Health Preservation and First Aid”, “The Four Highs Syndrome”, and "Respiratory and Digestive Diseases”. Gender, self-rated economic pressure, family size, and self-reported number of diseases were identified as influencing factors of health knowledge needs (P < 0.05). Thus, precision health education should be conducted according to the health knowledge needs of the target group, and various health knowledge topics should be organically integrated into modular health education to improve its efficiency.

Purpose To develop a set of Perineal Health Behavior Scale (PHBS) for adult female, and verify the reliability and validity of the scale. Methods The PHBS was developed using classical measures. The draft version of PHBS was compiled by semi-structured interview method (N = 8), Delphi expert consultation method (N = 5), and cognitive interviewing techniques (N = 20). A total of 1397 rural women from Huaning County were selected to participate in the survey. After items screening, the reliability and validity of final version of PHBS were verified. The influencing factors of perineal health behavior were explored by Multiple linear regression analysis. Results There were 11 items in the PHBS, including two dimensions – daily life (7 items), and sexual life (4 items). The scale had good structural validity, convergent validity, discriminant validity, content validity, internal consistency reliability, and split-half reliability. Multiple linear regression showed that suburban rural areas, higher education, and good family relationships were protective factors for poor perineal hygiene behavior (P < 0.05); High social pressure, irregular menstrual cycle, normal/less menstrual volume, and self-reported current genital tract infection are risk factors for poor perineal hygiene behavior (P < 0.05). Conclusions The PHBS was a reliable and valid measure to evaluate the level of perineal health behavior in adult female. In the work of health education and health promotion, we should focus on improving the perineal hygiene behaviors and habits of adult female in rural communities (especially remote rural communities).

To investigate the cognition of cancer warning symptoms and cancer risk factors among Chinese college students, analyze the influencing factors, and explain the correlations between cancer cognition and cancer symptom discrimination, cancer fear and psychological distress. Chinese college students were recruited in this cross-sectional study funded by a summer social practice activity in Yunnan Province, China. Cognition rates of cancer warning symptoms and cancer risk factors were evaluated using Cancer Warning symptoms Cognition Questionnaire (CWSCQ) and Cancer Risk Factors Cognition Questionnaire (CRFCQ), respectively. Factors associated with cognition of cancer warning symptoms, and factors associated with cognition of cancer risk factors were evaluated using multiple linear regression analysis. Interactions between cancer cognition, cancer symptom discrimination, psychological distress, and cancer fear were evaluated by structural equation modeling. There were 846 effective samples, with an effective rate of 80.9%. The cognition rates of cancer warning symptoms were from 47.9% to 84.4%, which were affected by cancer symptom discrimination, education, attitudes towards cancer screening, living expenses, drinking history, and ways to obtain cancer knowledge (p < 0.05). The cognition rates of cancer risk factors were from 46.3% to 91.3% in participants, which were affected by education, cancer symptom discrimination, psychological distress, attitudes towards cancer screening, life satisfaction, cancer history in relatives and friends, ways to obtain cancer knowledge, smoking history, and nursing history for cancer patients (p < 0.05). Cancer cognition and cancer symptom discrimination showed intermediary effects on psychological distress and cancer fear (p < 0.001). The overall cancer cognition situation among Chinese college students is not optimistic, which highlights the necessity of improving the cancer health literacy among Chinese college students. With the increasing morbidity and mortality rates of cancer, it is necessary to raise awareness of early detection, and early treatment of cancer among the general public. Health education interventions are helpful to improve cancer health literacy.

To develop a Fear of Cancer Scale (FOCS) for non-cancer populations.FOCS was developed by classical measurement theory. A total of 15 college students were invited to conduct semi-structured interv...