Nidhi Sharma

Background: The prevalence of cancer is around the world and is identified as a multifactorial ailment. One of the most common causes of cancer in the world is oxidative stress, and this can be overcome by taking herbal plant wheatgrass in any form. As colloidal carriers with particle sizes of 50-1,000nm, Solid Lipid Nanoparticles (SLNs) combine the benefits of liposomes, emulsions, and other colloidal systems to deliver drugs at their targets. Objective: Aim and objective of the present work is to formulate wheatgrass extract loaded solid lipid nanoparticles using Central Composite design and to investigate the effect of formulation variables. Using hot homoginization method, the present work aimed to formulate wheatgrass loaded chitosan solid lipid nanoparticles using central composite design and to evaluate the extract potential to treat breast cancer on MCF-7 cell line. Methods: This study investigated the effect of three formulation variables on particle size, namely the sodium alginate concentration, the calcium carbonate concentration, and the homogination time. Extraction of wheatgrass was done in soxhlet extractor, using methanolic extract. The hot homogenization technique was used to prepare Triticum aestivum extract loaded solid lipid nanoparticles (SLNs). Result: For CCD, all formulations were analyzed for particle size, which ranged from 362.5 to 933.8 nm, and for polydispersity index, which ranged from 0.137 to 5.799. Batch code SLN-6 was found to be finest suitable because of maximum loading capacity of 67.76 ±0.17 % (w/w), maximum entrapment efficiency of 65.81 ± 0.11 % (w/w) and minimum particle size of 362.5nm by using sodium alginate as surface stabilizer at homogenization time ~ 5 min and having maximum percentage yield of 43.66%. Conclusion: During characterization studies and MCF-6 cell line studies, it was found that batch code SLN-6 was found to be finest suitable and wheatgrass has anti-oxidant potential, and potent against breast cancer.

Since the content of the article shows a high degree of similarity to a previously published work by the same groupof authors, the article has been withdrawn from the journal Recent Patents on Nanotechnology with the consent ofthe Editor-in-Chief.Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policiesmain.phpBentham Science Disclaimer:It is a condition of publication that manuscripts submitted to this journal have not been published and will not besimultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has beenpublished elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism isstrictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legalright to take appropriate action against the authors, if plagiarism or fabricated information is discovered. Bysubmitting a manuscript, the authors agree that the copyright of their article is transferred to the publishers if andwhen the article is accepted for publication.

Background: Novel Drug Delivery Systems (NDDS) provide numerous benefits compared to conventional dosage forms. Poor aqueous solubility, low bioavailability, frequent dosing, and particular hydrophilic lipophilic character of the drug are the biological factors associated with the traditional systems leading to the development of SLNs. Objective: For improving the solubility profile, enhancing the bioavailability, and attaining the best possible therapeutic effect of lipid inclined or aqueous inclined drug, formulating solid lipid nanoparticles is the best choice. Methods: Solid Lipid Nanoparticles (SLNs) have been projected as a colloidal carrier system with a size of 50–1,000 nm, collectively combining the benefits of other colloidal systems like liposomes, emulsions, etc., for delivering the drug at the target site. High absorption, high stability, and efficient drug packing enhance the pharmacokinetic and pharmacodynamic properties of the packed drug. Result: Solid Lipid Nanoparticles can be developed in different dosage forms and administered via routes such as nasal, rectal, oral, topical, vaginal, ocular, and parenteral. They have higher physicochemical stability and the batch size can be easily scaled up at a low cost. Lipophilic as well as hydrophilic drugs can be easily incorporated into solid lipid nanoparticles. Conclusion: In this manuscript, the authors have reviewed different aspects of solid lipid nanoparticles, major principles behind mechanism methods, recent patents, applications, and therapeutic potentials of solid lipid nanoparticles.

Mitochondria are important organelles for high energy synthesis, reactive oxygen species balancing, antiapoptotic molecule production, membrane stability, intracellular calcium buffering, neuroplasticity and neurotransmission. Dysfunction in mitochondria is considered to be involved in the pathophysiology of mental problems. It has been observed that several drug types used to treat brain illnesses can harm mitochondria by altering the oxidative phosphorylation system and the gene expression of mitochondria-related proteins. In some studies, it has been observed that mitochondrial biogenesis shows a therapeutic effect in the management of mitochondrial disorders. Many therapeutic compounds are effective in the activation of mitochondrial biogenesis. The comorbidity of mental problems observed in those with mitochondrial dysfunction and the change in the efficacy of the cellular respiratory system have attracted researchers to understand the pathways and possible therapeutic strategies in neurological disorders. This article has attempted to understand the impact of mitochondrial function and mitochondrial dysfunction in the pathogenesis of brain disorders to develop potential therapeutic drugs.

One of the major problems faced by health care professionals is the prediction of airway difficulties in apparently healthy subjects. Failed endotracheal intubation is a well-known reason for increased morbidity of patients including brain damage or even death. This study is focused on parameters used for prior determination of airway for predicting difficult intubation in healthy Indian populations. This study was done on 500 healthy individuals. Neck parameters were measured including inter-incisal distance, neck circumference, thyro-mental distance and sterno-mental distance. Mallampati classification and mandibular protrusion test were also carried out. Statistical analysis was done using SPSS software (V.25). MC class 3 and 4 percentages were higher in males in comparison to females. Mandibular protrusion test grade A and B percentage was higher in females while class C percentage was higher in males. The comparison of baseline values of the neck parameters (inter-incisal distance, neck circumference, thyro-mental distance and sterno-mental distance) was statistically significant (<0.05) in both genders. The purpose of the study is to find out the baseline values of parameters involved in assessing methods for difficult intubation in healthy Indian population.

Background: Plants having active constituents possess pharmaceutical use and nutritional values. Herbal medicine or food supplement is gaining popularity, as well as scientific research on wheatgrass as a “functional food”. Objective: The target behind accepting wheatgrass as a study for review is to have clinical and non-clinical investigations on the wheatgrass plant at an equivalent stage. To let individuals, think about different affirmed uses and activities of the plant. Methods: Plants having so many nutritional and therapeutic values have been selected for review so that consumers or patients could be benefitted from their therapeutic uses. Recently, the interests in the use of herbal products have grown dramatically in the western as well as developing countries. The review was extracted from searches performed on Google Scholars, Google Patents, etc. Data from sources have been collected and reported here at one place in order to provide further research on wheatgrass. Results : Wheatgrass is a high source of various vitamins and minerals; it possesses many activities like anti-oxidant, anti-inflammation, anti-bacterial and many more. Wheatgrass’ uses, benefits and properties non-clinical data and clinical studies has been thoroughly studied. Patents filed related to wheatgrass are mentioned here, so as to motivate other innovators to search for new activities or molecules. Conclusions: Wheatgrass can be used in pharmaceutical formulations and can be used as nutritional supplements due to its anti-oxidant nature, anti-microbial activity, anti-bacterial activity, anti-fungal activity. It is also called “Panacea on Earth” owing to its wide range of nutritive and medicinal aspects.

: Prostate Cancer (PC) is one the most prominent cause of deaths in males worldwide especially in western countries. The exhaustive research into prostate cancer to date has demonstrated ELAC2, RNASEL, MSR1, NBS1, CHEK2, MYC, BCL-2, c-Kit, tumor suppressor genes, BRCA1, BRCA2, PACE4, GSTP1, PTEN,CDKN1B, NKX3.1, KLF6, FOXA1, Retinoblastoma, p53, androgen receptor, kallikreins, ETS, CYP17, SRD5A2, E-cadherin, KAI1/CD82, hepsin, AMACR, PIM1, MTA-1, EZH2, EPHB2, growth factors & its receptors, cannabinoid receptors, annexins, oxidative stress and inflammation are entailed changes underlying the initiation, development, and progression of PC. Furthermore, oncology would shift from a reactive to proactive discipline so exploring these targets open new area of research. Therefore, the present review is focused on molecular pathophysiology biomarkers for the progression of PC that would encourage the researchers and pharmaceutical industries to investigate potential therapeutic strategy to overcome demerits of currently available clinically therapies.