Masoud Shirmohammadi

Background. Oral lichen planus (OLP) is a multifactorial chronic inflammatory condition with unknown etiology. This condition has been associated with Helicobacter pylori. This study aimed to investigate the relationship between the treatment of H. pylori infection and improvements in OLP lesions. Methods. In this cohort study, 42 patients with erosive or ulcerative OLP lesions were evaluated in terms of H. pylori infection using the H. pylori stool antigen (HpSA) test. The patients were divided into three groups. The first group consisted of 12 H. pylori-negative patients. The second group consisted of 21 H. pylori-positive patients receiving antibacterial treatment. The third group included nine H. pylori-positive patients not willing to receive treatment. All the three groups underwent the usual OLP treatment. Patients in the second and third groups were re-evaluated by the HpSA test after two months. The efficacy indexes and visual analog scale were used to evaluate clinical improvements. Results. The efficiency index and pain scores were affected by the intervention (P0.05) was obtained. Conclusion. Pain intensity was higher in patients with H. pylori than in those without H. pylori before treatment. Also, in patients with H. pylori, the treatment affects the complete recovery rate.

Background: Drug-resistant strains and poor treatment response is the main reason for the failure in Helicobacter pylori (H. pylori) eradication. Unsaturated fatty acids with more than one double bond (PUFAs) have inhibitory effect on bacterial growth. Therefore, the aim of this study is to investigate the effect of Omega fatty acids on caspase-8 gene expression in H. pylori infected patients with dyspeptic symptoms. Methods: In this double blind clinical trial study in which 34 H.pylori infected patients with dyspeptic symptoms were randomly divided into two groups of 17 patients, the control group receiving standard triple therapy (including amoxicillin, clarithromycin and omeprazole) and the intervention group receiving standard therapy with omega-3, omega-6 and omega-9 fatty acids for two weeks. After treatment, Gene expression levels of Caspase-8 enzymes as well as the semi-quantitative of these proteins were studied with PCR Real-time method and frozen section and immunohistochemistry, respectively. Results: In the case group compared with the control group, a significant increasing in the expression of caspase -8 genes was observed (p=0.002). The protein level of active caspase -8 enzymes was significantly increased in the case group compared with the control group (0.004). Conclusion: The Omega fatty acids along with standard triple therapy lead induce apoptosis is stomach.