SLSascha Lieber

Sascha Lieber

*This is an algorithmically generated author record based on publicly available information.

Current Organizations / Institutes

The organizations/institutes from the scholar's latest article

Previous Organizations / Institutes

The organizations / institutes from the scholar's other articles in the past ten years


Sascha Lieber has a total of 47 co-authors. Here are the top co-authors by number of shared publications:


Latest Publications

  • Open Access

    SARS-CoV-2 Infection, Risk Perception, Behaviour and Preventive Measures at Schools in Berlin, Germany, during the Early Post-Lockdown Phase: A Cross-Sectional Study

    by Franziska Hommes, Welmoed van Loon, Marlene Thielecke, Igor Abramovich, Sascha Lieber, Ralf Hammerich, Sabine Gehrke-Beck, Elisabeth Linzbach, Angela Schuster, Katja von Dem Busche, et al.

    Briefly before the first peak of the COVID-19 pandemic in Berlin, Germany, schools closed in mid-March 2020. Following re-opening, schools resumed operation at a reduced level for nine weeks. During this phase, we aimed at assessing, among students and teachers, infection status, symptoms, individual behaviour, and institutional infection prevention measures. Twenty-four primary and secondary school classes, randomly selected across Berlin, were examined. Oro-nasopharyngeal swabs and capillary blood samples were collected to determine SARS-CoV-2 infection (PCR) and specific IgG (ELISA), respectively. Medical history, household characteristics, leisure activities, fear of infection, risk perception, hand hygiene, facemask wearing, and institutional preventive measures were assessed. Descriptive analysis was performed. Among 535 participants (385 students, 150 staff), one teenager was found to be infected with SARS-CoV-2 (0.2%), and seven individuals exhibited specific IgG (1.3%). Compared to pre-pandemic times, screen time (e.g., TV, gaming, social media) increased, and the majority of primary school students reported reduced physical activity (42.2%). Fear of infection and risk perception were relatively low, acceptance of adapted health behaviors was high. In this post-lockdown period of low SARS-CoV-2 incidence in Berlin, individual and school-level infection prevention measures were largely adhered to. Nevertheless, vigilance and continued preventive measures are essential to cope with future pandemic activity.


  • Open Access

    Interdisciplinary Online Hackathons as an Approach to Combat the COVID-19 Pandemic: Case Study

    by Katarina Braune, Pablo-David Rojas, Joscha Hofferbert, Alvaro Valera Sosa, Anastasiya Lebedev, Felix Balzer, Sylvia Thun, Sascha Lieber, Valerie Kirchberger, Akira-Sebastian Poncette

    Background: The COVID-19 outbreak has affected the lives of millions of people by causing a dramatic impact on many health care systems and the global economy. This devastating pandemic has brought together communities across the globe to work on this issue in an unprecedented manner. Objective: This case study describes the steps and methods employed in the conduction of a remote online health hackathon centered on challenges posed by the COVID-19 pandemic. It aims to deliver a clear implementation road map for other organizations to follow. Methods: This 4-day hackathon was conducted in April 2020, based on six COVID-19–related challenges defined by frontline clinicians and researchers from various disciplines. An online survey was structured to assess: (1) individual experience satisfaction, (2) level of interprofessional skills exchange, (3) maturity of the projects realized, and (4) overall quality of the event. At the end of the event, participants were invited to take part in an online survey with 17 (+5 optional) items, including multiple-choice and open-ended questions that assessed their experience regarding the remote nature of the event and their individual project, interprofessional skills exchange, and their confidence in working on a digital health project before and after the hackathon. Mentors, who guided the participants through the event, also provided feedback to the organizers through an online survey. Results: A total of 48 participants and 52 mentors based in 8 different countries participated and developed 14 projects. A total of 75 mentorship video sessions were held. Participants reported increased confidence in starting a digital health venture or a research project after successfully participating in the hackathon, and stated that they were likely to continue working on their projects. Of the participants who provided feedback, 60% (n=18) would not have started their project without this particular hackathon and indicated that the hackathon encouraged and enabled them to progress faster, for example, by building interdisciplinary teams, gaining new insights and feedback provided by their mentors, and creating a functional prototype. Conclusions: This study provides insights into how online hackathons can contribute to solving the challenges and effects of a pandemic in several regions of the world. The online format fosters team diversity, increases cross-regional collaboration, and can be executed much faster and at lower costs compared to in-person events. Results on preparation, organization, and evaluation of this online hackathon are useful for other institutions and initiatives that are willing to introduce similar event formats in the fight against COVID-19.


  • Open Access

    SARS-CoV-2 infection, risk perception, behaviour, and preventive measures at schools in Berlin, Germany, during the early post-lockdown phase: A cross-sectional study

    by Franziska Hommes, Welmoed van Loon, Marlene Thielecke, Igor Abramovich, Sascha Lieber, Ralf Hammerich, Sabine Gehrke-Beck, Elisabeth Linzbach, Angela Schuster, Katja von Dem Busche, et al.

    Background Briefly before the first peak of the COVID-19 pandemic in Berlin, Germany, schools closed in mid-March 2020 for six weeks. Following re-opening, schools gradually resumed operation at a reduced level for nine weeks preceding the summer holidays. Aim During this phase, we conducted a situational assessment in schools among students and teachers as to infection status, symptoms, affective, behavioural, educational issues, and preventive measures. Methods At twenty-four randomly selected primary and secondary schools, one class each was examined. Oro-nasopharyngeal swabs and capillary blood samples were collected to assess SARS-CoV-2 infection (PCR) and specific IgG (ELISA), respectively. Medical history, household and schooling characteristics, leisure time activities, fear of infection, risk perception, hand hygiene, physical distancing, and facemask wearing were assessed. Results Among 535 participants (385 students, 150 staff), one teenager was SARS-CoV-2 infected (0.2%), and seven individuals exhibited specific IgG (1.3%); 16% reported symptoms upon examination, and 48% in the preceding 14 days. Compared to before the pandemic, the proportion of leisure time spent as screen-time increased, and the majority of primary school students reported reduced physical activity. Fear of infection and risk perception were relatively low, but acceptance of adapted health behaviours was high. Governmental preventive measures were adequately implemented, with primary schools performing better than secondary schools. Conclusion: In this phase of rare infection and low seroreactivity, individual and school-level infection prevention and control measures were largely adhered to. Nevertheless, vigilance, continued and proactive preventive measures, and well-rehearsed reaction options are essential to cope with increasing pandemic activity.


  • Open Access

    Interdisciplinary Online Hackathons as an Approach to Combat the COVID-19 Pandemic: Case Study (Preprint)

    by Katarina Braune, Pablo-David Rojas, Joscha Hofferbert, Alvaro Valera Sosa, Anastasiya Lebedev, Felix Balzer, Sylvia Thun, Sascha Lieber, Valerie Kirchberger, Akira-Sebastian Poncette

    BACKGROUND The COVID-19 outbreak has affected the lives of millions of people by causing a dramatic impact on many health care systems and the global economy. This devastating pandemic has brought together communities across the globe to work on this issue in an unprecedented manner. OBJECTIVE This case study describes the steps and methods employed in the conduction of a remote online health hackathon centered on challenges posed by the COVID-19 pandemic. It aims to deliver a clear implementation road map for other organizations to follow. METHODS This 4-day hackathon was conducted in April 2020, based on six COVID-19–related challenges defined by frontline clinicians and researchers from various disciplines. An online survey was structured to assess: (1) individual experience satisfaction, (2) level of interprofessional skills exchange, (3) maturity of the projects realized, and (4) overall quality of the event. At the end of the event, participants were invited to take part in an online survey with 17 (+5 optional) items, including multiple-choice and open-ended questions that assessed their experience regarding the remote nature of the event and their individual project, interprofessional skills exchange, and their confidence in working on a digital health project before and after the hackathon. Mentors, who guided the participants through the event, also provided feedback to the organizers through an online survey. RESULTS A total of 48 participants and 52 mentors based in 8 different countries participated and developed 14 projects. A total of 75 mentorship video sessions were held. Participants reported increased confidence in starting a digital health venture or a research project after successfully participating in the hackathon, and stated that they were likely to continue working on their projects. Of the participants who provided feedback, 60% (n=18) would not have started their project without this particular hackathon and indicated that the hackathon encouraged and enabled them to progress faster, for example, by building interdisciplinary teams, gaining new insights and feedback provided by their mentors, and creating a functional prototype. CONCLUSIONS This study provides insights into how online hackathons can contribute to solving the challenges and effects of a pandemic in several regions of the world. The online format fosters team diversity, increases cross-regional collaboration, and can be executed much faster and at lower costs compared to in-person events. Results on preparation, organization, and evaluation of this online hackathon are useful for other institutions and initiatives that are willing to introduce similar event formats in the fight against COVID-19.

  • Open Access

    Long-term small-fiber neuropathy and pain sensitization in survivors of pediatric acute lymphoblastic leukemia after stem cell transplantation

    by Victoria Ruscher, Sascha Lieber, Jörn-Sven Kühl, Johannes Schulte, Markus Blankenburg, Tobias Reindl, Pablo Hernáiz Driever

    Purpose: We aimed at describing for the first time peripheral small-fiber neurotoxicity and pain sensitization in survivors of pediatric acute lymphoblastic leukemia after stem cell transplantation (SCT). Methods: In a cross-sectional, retrospective, single-center study, we assessed 25 relapse-free long-term survivors (median age at SCT: 11 ± 4.9 years; median time between SCT and testing: 8.25 years, 19 males) using a reduced version of the pediatric-modified total neuropathy score for clinical assessment and Quantitative Sensory Testing (QST). Inclusion criteria: $$\ge$$ ≥ 6 years old at testing, $$\le$$ ≤ 18 years old at time of SCT, $$\ge$$ ≥ 1 year between SCT and testing. Results: Nine patients (36%) had peripheral neuropathy as defined by the clinical red-pmTNS (≥ 4). The QST parameters mechanical pain sensitivity, mechanical detection threshold, thermal sensory limen, vibration detection threshold and pressure pain threshold were significantly abnormal in the survivor cohort (p < 0.0038). Except for one, all survivors showed at least one abnormal QST parameter. When using QST, signs of small and large fiber dysfunction were present in 22 (88%) and 17 (68%) survivors, respectively. More than half of all survivors were found to experience pathologic sensitization to pain. Conclusions and implications for cancer survivors: Survivors of pediatric acute lymphoblastic leukemia after SCT are at high risk for long-term peripheral neuropathy with a dominating small-fiber and pain sensitization pattern.


  • Small-fiber neuropathy and pain sensitization in survivors of pediatric acute lymphoblastic leukemia

    by S. Lieber, M. Blankenburg, K. Apel, G. Hirschfeld, P. Hernáiz Driever, T. Reindl