LLLiMing Liu

LiMing Liu

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LiMing Liu has a total of 35 co-authors. Here are the top co-authors by number of shared publications:


Latest Publications

  • Open Access

    3D preoperative plan assisted total knee arthroplasty after knee arthrodesis with patella absence: a case report

    by Li-Ming Liu, Kai Lei, Peng-Fei Yang, Lin Guo

    The conversion of knee arthrodesis to total knee arthroplasty (TKA) is a challenging procedure. This article aims to report a case of fusion knee with patellar absence who was converted to TKA and has achieved good results. The patient, a 23 years old Tibetan Buddhist monk, sustained a left knee joint injury at the age of 12 due to a car accident, leading to subsequent knee arthrodesis at 18 years old as a result of recurrent severe infections. However, this procedure hindered his ability to perform daily meditation practices that required bending both knees and sitting cross-legged. After adequate preoperative preparation, with the help of customized osteotomy guide plate and customized 3D-printed porous tantalum patella, the 3D preoperative plan assisted TKA after arthrodesis was performed. The knee function was followed up to explore the clinical effect of above-mentioned surgical procedure. A 1-year follow-up showed significant improvement in postoperative knee function with improved scores for function outcomes, and the patient was satisfied with the conversion. The patient’s left knee improved significantly from preoperative immobility with 5° of fixed fusion to postoperative ROM of 0° to 100°, and the patient could squat and stand up, walk on the flat ground, and go up and down stairs. Adequate preoperative communication with patients and good expectation management are crucial for ensuring favorable prognoses. Perfect preoperative planning and its reliable implementation during operation are essential. Additionally, postoperative rehabilitation and proactive management of complications play pivotal roles in achieving optimal clinical outcomes. IV.


  • Functional knee phenotypes appear to be more suitable for the Chinese OA population compared with CPAK classification: A study based on 3D CT reconstruction models

    by LiMing Liu, Kai Lei, Dekai Du, Yong Lin, Zhaoxun Pan, Lin Guo

    Purpose: The aim of this study was to investigate the distribution of coronal plane alignment of the knee (CPAK) classification and functional knee phenotypes in a Chinese osteoarthritis (OA) population and to compare different lower limb alignment targets according to the distribution characteristics to find suitable total knee arthroplasty (TKA) bone cut strategies for the Chinese OA patients.Methods: The computed tomography (CT) images were retrospectively collected and the three‐dimensional (3D) models were reconstructed from 434 Chinese OA patients, including 93 males and 341 females, with a mean age of 66.4 ± 9.3 years. Femoral mechanical angle (FMA), tibial mechanical angle (TMA) and mechanical hip–knee–ankle angle (mHKA) were measured on the 3D models. Arithmetic hip–knee–ankle angle (aHKA) was calculated using FMA plus TMA, and joint line obliquity was calculated as 180 + TMA–FMA. The CPAK according to MacDessi and the functional knee phenotypes according to Hirschmann were performed. In addition, the suitable TKA bone cut strategies were explored according to the phenotypes and based on the characteristics of different alignment targets, such as mechanical alignment, anatomic alignment (AA), kinematic alignment, restricted KA (rKA) and adjusted MA (aMA). Statistical differences were determined using the independent‐samples t‐test or the two independent‐samples Wilcoxon test, with p < 0.05 considered statistically significant.Results: The Chinese OA population showed a varus alignment tendency (mHKA = 172.1° ± 7.2°), to which the TMA was a major contributor (TMA = 84.7° ± 4.4° vs. FMA = 91.3° ± 3.2°). The mHKA was on average 3.9° more varus than the aHKA. A total of 140 functional knee phenotypes were found and 45.6% were concentrated in VARFMA3°–NEUFMA0° to VARTMA3°–NEUTMA0°. More than 70% of patients had different FMA and TMA phenotypes. There were 92.9% of CPAK distributed in types I to IV, with type I accounting for 53.9%. The FMA phenotypes were less changed if the aMA and rKA were chosen, and the TMA phenotypes were less changed if the AA and rKA were chosen.Conclusion: Compared with the CPAK, the functional knee phenotypes were more suitable for the Chinese OA population with a wide distribution and a varus tendency, and it seemed more appropriate to choose aMA and rKA as TKA alignment targets for resection.Level of Evidence: Level Ⅲ.


  • A Torn Discoid Lateral Meniscus Impacts Lower-Limb Alignment Regardless of Age

    by Kai Lei, Liming Liu, Liu Yang, Lin Guo, Dejie Fu

    Background: A discoid lateral meniscus (DLM) is more prone to tear, and treatment of this condition is challenging. The purpose of the present study was to investigate (1) whether a torn DLM is associated with more varus alignment than a torn semilunar lateral meniscus (SLM) and (2) whether the lower-limb alignment associated with a torn DLM changes with age. Methods: Consecutive patients who underwent arthroscopic knee surgery for a torn lateral meniscus were included. Patients with a torn DLM (confirmed on arthroscopy) were allocated to the DLM group; those with a torn SLM were allocated to the SLM group. After strict screening according to the inclusion and exclusion criteria, 436 and 423 patients were included in the DLM and SLM groups, respectively. The mechanical axis deviation (MAD), hip-knee-ankle angle (HKA), mechanical lateral distal femoral angle, and medial proximal tibial angle were compared between the 2 groups after propensity score matching. Additionally, the correlation of the HKA and MAD with age was evaluated within the DLM group. Results: After propensity score matching, all baseline characteristics were well balanced between the 2 groups. The DLM group had significantly more varus alignment than the SLM group (MAD: 3.6 mm ± 9.6 mm versus 1.1 mm ± 10.3 mm, respectively, p = 0.001; HKA: 179.1° ± 2.9° versus 179.9° ± 3.0°, respectively, p = 0.001). Within the DLM group, the MAD (R = 0.10, p = 0.032) and HKA (R = −0.13, p = 0.007) had a weak correlation with age. Conclusions: Patients with a torn DLM had more varus knee alignment than those with a torn SLM, and this trend did not increase with age after minimizing the effects of osteoarthritis. Therefore, surgical treatment may not be appropriate for asymptomatic DLM. Level of Evidence: Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.


  • Open Access

    Clinical evaluation of the first semi-active total knee arthroplasty assisting robot made in China: a retrospective propensity score-matched cohort study

    by Pengfei Yang, Rui He, Kai Lei, Liming Liu, Liu Yang, Lin Guo

    Objective: The precision of overall alignment and knee morphotype after robot-assisted total knee arthroplasty has been fully confirmed. This study aims to conduct a clinical evaluation of the first China-made semi-active total knee arthroplasty assisting robot. Methods: After a 1 : 2 propensity score matching, that is, a matched cohort study, patients were matched to the robot group (52 cases) and the conventional group (104 cases). The robot group received osteotomy according to preoperative planning, while the conventional group adopted preoperative planning based on the full-length radiograph and received conventional osteotomy. Perioperative clinical indicators, such as operation time, tourniquet time, hospitalization days, intraoperative bleeding, and hemoglobin level of the two groups were recorded; radiological indicators of postoperative prosthesis position, including hip-knee-ankle angle, frontal femoral component angle, frontal tibial component angle, lateral femoral component angle, and lateral tibial component angle were also recorded; deviations and outliers of the radiological indicators were calculated. Results: Compared with the conventional group, the operation time and tourniquet time of the robot group were longer, and the postoperative hemoglobin level decreased less, the differences were statistically significant; the lateral tibial component angle of the conventional group was 80.9°±3.6°, which was smaller than 86.7 °±2.3° of the robot group, the difference was statistically significant (PP≤0.001); the outliers of the radiological indicators in the robot group were significantly smaller than that in the conventional group with a statistical difference (P<0.05). Conclusion: Compared with the conventional group, the operation time of the robot group was relatively longer, but the perioperation blood loss was less. The robot group could better control the posterior inclination of the tibial prosthesis, and the absolute deviations and outliers of the prosthesis position were relatively smaller. There was no difference in short-term clinical score between the two groups.


  • Open Access

    Hip Pain after Distal Femoral Derotational Osteotomy for a Patient with Patellar Instability: A Case Report

    by De‐Jie Fu, Kai Lei, Li‐Ming Liu, Lin Guo

    Background: Increased torsional deformity of femur is one of the most important factors in recurrent patellofemoral instability. And distal femoral derotational osteotomy is an effective treatment option in patients with increased femoral torsional deformity. However, groin pain is a rare complication after femoral derotational osteotomy.Case presentation: The patient was a 23‐year‐old female suffering from anterior knee pain and patellar instability in her left leg. Continuous CT scans of the hip, knee, and ankle were performed and the femoral anteversion was 44.99°. Considering the significant enlargement of the femoral internal torsion which may contribute most for dislocation of patella, we did a derotational osteotomy of distal femur. The anterior knee pain and patellar instability were resolved after surgery. The femoral internal torsion angle was corrected to 21.47°. But she developed left hip pain in the groin area which she had never encountered before 1 year after the surgery. We believed that the hip pain was closely related to the surgery. And the imaging and follow‐up partly confirmed this.Conclusions: The situation of the hip joint should be carefully evaluated before doing derotational osteotomy in recurrent patellofemoral instability and patient should be informed that derotational osteotomy may cause hip pain. Clinical studies are needed to further clarify the impact of derotational osteotomy on the hip.


  • Open Access

    Robotic systems in total knee arthroplasty: current surgical trauma perspectives

    by Kai Lei, Li-Ming Liu, Lin Guo

    Total knee arthroplasty (TKA) has been a successful solution for end-stage osteoarthritis for decades. Restoring neutral lower limb alignment with a well-positioned prosthesis is considered one of the most important goals for successful TKA. Multiple new technologies, including robot-assisted TKA (RA-TKA), have been developed to achieve precise TKA surgery. Over decades of usage, robotic arm registration and installation have been approved for operative accuracy and criticized for increased perioperative times and surgical trauma. The limitation of surgical trauma is a rarely discussed but equally important factor when the decision to choose RA-TKA is about to be made.


  • Open Access

    Surgical Transepicondylar Axis Is Not a Reliable Reference when there Was Lateral Femoral Bowing

    by LiMing Liu, Kai Lei, Lin Guo, Xin Chen, PengFei Yang, DeJie Fu, Ran Xiong, Liu Yang

    Objective: The surgical transepicondylar axis (sTEA) is believed to be a consistent reference for femoral rotation axis, and the reliability of its orientation seriously affects the accuracy and outcome of total knee arthroplasty (TKA). This study was designed to investigate the relationship between the orientation of sTEA and femoral bowing angle (FBA) and posterior condylar line (PCL) using three‐dimensional (3D) computed tomography (CT) reconstruction models to verify its reliability.Methods: This study retrospectively collected lower extremity images of 443 southern Chinese osteoarthritic patients (347 women, 96 men; 234 left, 209 right; mean age 66.5 ± 9.3 years) from August 2016 to June 2018. The hip–knee‐ankle angle (HKA) was measured on anteroposterior weight‐bearing full lower extremity standing radiographs. Measurements on 3D CT models of the femurs included lateral angle between the femoral mechanical axis and sTEA coronal angle, angle between sTEA and distal joint line (distal condylar axis angle, DCA); angle between sTEA and PCL (sTEA axial angle); angle between anatomical axis of proximal femur and anatomical axis of distal femur in the plane they form (actual FBA) and its projection on the coronal (lateral FBA) and sagittal (anterior FBA) planes. The correlations between sTEA coronal angle, sTEA axial angle and actual FBA, lateral FBA, anterior FBA, HKA, DCA were explored using the Spearman correlation test.Results: The mean value of actual FBA is (14.4 ± 3.6)°, of lateral FBA is (6.0 ± 4.0)°, and of anterior FBA is (12.7 ± 3.0)°. The mean value of sTEA coronal angle is (88.7 ± 3.6)°, of sTEA axial angle is (2.1 ± 2.8)°. The sTEA coronal angle was positively correlated with actual FBA (r = 0.320, P < 0.01), lateral FBA (r = 0.448, P < 0.01), anterior FBA (r = 0.113, P < 0.05), HKA (r = 0.482, P < 0.01) and DCA (r = 0.486, P < 0.01). The sTEA axial angle was positively correlated with DCA (r = 0.168, P < 0.01), but not significantly correlated with all FBAs and HKA (NS).Conclusion: The sTEA cannot be used as a stable reference when there was an obvious femoral bowing deformity. As the lateral femoral bowing increases, the orientation of sTEA becomes more varus, no matter the knee is varus or valgus.


  • Open Access

    Could surgical transepicondylar axis be identified accurately in preoperative 3D planning for total knee arthroplasty? A reproducibility study based on 3D-CT

    by Kai Lei, Li Ming Liu, Jiang Ming Luo, Chao Ma, Qing Feng, Liu Yang, Lin Guo

    Background: Surgical transepicondylar axis (sTEA) is frequently used for positioning of femoral component rotation in total knee arthroplasty (TKA). Previous studies showed that intraoperative identification of sTEA was not reliable. While surgeons or engineers need to identify sTEA with three-dimensional (3D) computer-aid techniques pre- or intraoperatively, the reproducibility of sTEA identification on preoperative 3D images has not been explored yet. This study aimed to investigate the reproducibility of identifying sTEA in preoperative planning based on computed tomography (CT). Methods: Fifty-nine consecutive patients (60 knees involved) who received TKA in our center from April 2019 to June 2019 were included in this study. Six experienced TKA surgeons identified sTEA three times on 3D model established on the basis of knee CT data. The projection angle of each sTEA and the posterior condyle axis on the transverse plane were measured and analyzed. Results: The overall intra-observer reproducibility was moderate. The median intra-observer variation was 1.27°, with a maximum being up to 14.07°. The median inter-observer variation was 1.24°, and the maximum was 11.47°. The overall intra-class correlation coefficient (ICC) for inter-observer was 0.528 (95% CI 0.417, 0.643). Conclusion: The identification of sTEA on a 3D model established on the basis of knee CT data may not be reliable. Combined with the previous cadaveric and surgical studies, caution should be exercised in determining femoral component rotation by referencing sTEA both preoperatively and intraoperatively. Level of evidence: III


  • Open Access

    Robotics versus personalized 3D preoperative planning in total knee arthroplasty: a propensity score-matched analysis

    by Kai Lei, LiMing Liu, PengFei Yang, Ran Xiong, Liu Yang, Rui He, Lin Guo

    Purpose: Lower limb alignment is crucial in total knee arthroplasty (TKA). Previous studies have shown that robotics and personalized three-dimensional (3D) preoperative planning could improve postoperative alignment accuracy compared with conventional TKA, but comparison between the above two techniques has never been reported. The authors hypothesized that robotics may be superior to personalized 3D preoperative planning in terms of postoperative alignment in primary TKA, with similar patient-reported outcome measures (PROMs) but higher cost and longer operative time. Methods: A consecutive series of patients who received TKA in our center from September 2020 to January 2021 were enrolled retrospectively. After 1:2 matching, 52 and 104 patients were included and divided into study group for robotics and control group for personalized 3D preoperative planning, respectively. Multiple postoperative alignment angles were measured, and clinical features such as operation and tourniquet time, length of hospital stay and hemoglobin (Hb) were recorded. Knee Society Score (KSS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) were used to evaluate clinical results. Results: Compared with control group, robotics group had significantly lower frontal femoral component angle (FFC) and frontal tibial component angle (FTC) absolute deviation (P < 0.05). It also had less outliers in hip–knee–ankle angle (HKA), FTC, lateral femoral component angle (LFC) and lateral tibial component angle (LTC) (P < 0.05). Hb loss of robotics group was significantly lower than control group (P < 0.001), while the operation and tourniquet time were longer (P < 0.001). There was no significant difference in KSS and WOMAC scores between two groups. Conclusion: Compared with control group, patients in robotics group had significantly less malalignment, malposition, Hb loss, but similar PROMs. The operations in robotics group spent longer operation time and cost more compared with control group. Trial registration: The Chinese Clinical Trial Registry, ChiCTR2000036235. Registered 22 August 2020, http://www.chictr.org.cn/showproj.aspx?proj=59300. Level of evidence: III.


  • Open Access

    Slight femoral under-correction versus neutral alignment in total knee arthroplasty with preoperative varus knees: a comparative study

    by Kai Lei, Li-Ming Liu, Peng-Fei Yang, Ran Xiong, De-Jie Fu, Liu Yang, Lin Guo

    Background This study aimed to compare the short-term clinical results of slight femoral under-correction with neutral alignment in patients with preoperative varus knees who underwent total knee arthroplasty. Methods The medical records and imaging data were retrospectively collected from patients who had undergone total knee arthroplasty in our hospital from January 2016 to June 2019. All patients had varus knees preoperatively. Upon 1:1 propensity score matching, 256 patients (256 knees) were chosen and divided into a neutral alignment group (n=128) and an under-correction group (n=128). The patients in the neutral group were treated with the neutral alignment. In the under-correction group, the femoral mechanical axis had a 2 degrees under-correction. The operative time, tourniquet time and the length of hospital stay in the two groups were recorded. The postoperative hip-knee-ankle angle, frontal femoral component angle and frontal tibial component angle were measured. Patient-reported outcome measures were also compared. Results The operative time, tourniquet time and the length of hospital stay in the under-correction group were significantly shorter than the neutral alignment group (P<0.05). At the 2-year follow-up, the under-correction group had a larger varus alignment (P<0.05) and a larger frontal femoral component angle (P<0.05), and the frontal tibial component angles of the two groups were comparable. Compared with the neutral alignment group, the slight femoral under-correction group had significantly better patient-reported outcome measures scores (P<0.05). Conclusion For varus knees treated with total knee arthroplasty, alignment with a slight femoral under-correction has advantages over the neutral alignment in terms of the shorter operative time and better short-term clinical results.