Mayada M. El-Ayouty
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Previous Organizations / Institutes
The organizations / institutes from the scholar's other articles in the past ten years
Research Subjects
Mayada M. El-Ayouty has a total of 21 co-authors. Here are the top co-authors by number of shared publications:
- Ahmed M. Badawy
Department of Pharmacognosy, Faculty of Pharmacy, Sinai University, El-Arish 45511, Egypt
3 shared publications - Safwat AbdelMaksoud Ahmed
Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt
3 shared publications - Ashootosh Tripathi
Natural Products Discovery Core, Life Sciences Institute, University of Michigan, Ann Arbor, USA
2 shared publications - Khaled Mohamed Darwish
Department of Medicinal Chemistry, Faculty of Pharmacy, Galala University, New Galala 43713, Egypt
2 shared publications - Mohamed Shaban Nafie
Department of Chemistry, College of Sciences, University of Sharjah, Sharjah 27272, United Arab Emirates
2 shared publications - Osama G. Mohamed
Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt
2 shared publications
Latest Publications
- 22 August 2024
- Published by Royal Society of Chemistry (RSC) in RSC Medicinal Chemistry
- Vol. 15 (9) , 3228-3238
Cornulacin: a new isoflavone from Cornulaca monacantha and its isolation, structure elucidation and cytotoxicity through EGFR-mediated apoptosis
Cornulacin, a new isoflavone, was isolated from Cornulaca monacantha with structural elucidation and cytotoxicity against ovarian A2780 cancer through apoptosis induction.
- 22 August 2024
- Published by Royal Society of Chemistry (RSC) in RSC Medicinal Chemistry
- Vol. 15 (9) , 3228-3238
Cornulacin: a new isoflavone from Cornulaca monacantha and its isolation, structure elucidation and cytotoxicity through EGFR-mediated apoptosis
Cornulacin, a new isoflavone, was isolated from Cornulaca monacantha with structural elucidation and cytotoxicity against ovarian A2780 cancer through apoptosis induction.
- 7 August 2024
- Published by Royal Society of Chemistry (RSC) in Organic & Biomolecular Chemistry
- Vol. 22 (34) , 7006-7016
Dual SARS-CoV-2 and MERS-CoV inhibitors from Artemisia monosperma : isolation, structure elucidation, molecular modelling studies, and in vitro activities
The COVID-19 pandemic has spread throughout the whole globe, so it is imperative that all available resources be used to treat this scourge.
- 7 August 2024
- Published by Royal Society of Chemistry (RSC) in Organic & Biomolecular Chemistry
- Vol. 22 (34) , 7006-7016
Dual SARS-CoV-2 and MERS-CoV inhibitors from Artemisia monosperma : isolation, structure elucidation, molecular modelling studies, and in vitro activities
The COVID-19 pandemic has spread throughout the whole globe, so it is imperative that all available resources be used to treat this scourge.
- Open Access
- 5 August 2024
- Published by Royal Society of Chemistry (RSC) in RSC Advances
- Vol. 14 (34) , 24503-24515
In vivo determination of analgesic and anti-inflammatory activities of isolated compounds from Cleome amblyocarpa and molecular modelling for the top active investigated compounds
Cleome amblyocarpa Barr. and Murb. from the family Cleomaceae is used in folk medicine as it has analgesic, anti-inflammatory, antibacterial and antioxidant activities.
- 5 August 2024
- Published by Royal Society of Chemistry (RSC) in RSC Advances
- Vol. 14 (34) , 24503-24515
Open AccessIn vivo determination of analgesic and anti-inflammatory activities of isolated compounds from Cleome amblyocarpa and molecular modelling for the top active investigated compounds
Cleome amblyocarpa Barr. and Murb. from the family Cleomaceae is used in folk medicine as it has analgesic, anti-inflammatory, antibacterial and antioxidant activities.
- Open Access
New Antiproliferative Triflavanone from Thymelaea hirsuta—Isolation, Structure Elucidation and Molecular Docking Studies
In this study isolates from Thymelaea hirsuta, a wild plant from the Sinai Peninsula of Egypt, were identified and their selective cytotoxicity levels were evaluated. Phytochemical examination of the ethyl acetate (EtOAc) fraction of the methanolic (MeOH) extract of the plant led to the isolation of a new triflavanone compound (1), in addition to the isolation of nine previously reported compounds. These included five dicoumarinyl ethers found in Thymelaea: daphnoretin methyl ether (2), rutamontine (3), neodaphnoretin (4), acetyldaphnoretin (5), and edgeworthin (6); two flavonoids: genkwanin (7) and trans-tiliroside (8); p-hydroxy benzoic acid (9) and β sitosterol glucoside (10). Eight of the isolated compounds were tested for in vitro cytotoxicity against Vero and HepG2 cell lines using a sulforhodamine-B (SRB) assay. Compounds 1, 2 and 5 exhibited remarkable cytotoxic activities against HepG2 cells, with IC50 values of 8.6, 12.3 and 9.4 μM, respectively, yet these compounds exhibited non-toxic activities against the Vero cells. Additionally, compound 1 further exhibited promising cytotoxic activity against both MCF-7 and HCT-116 cells, with IC50 values of 4.26 and 9.6 μM, respectively. Compound 1 significantly stimulated apoptotic breast cancer cell death, resulting in a 14.97-fold increase and arresting 40.57% of the cell population at the Pre-G1 stage of the cell cycle. Finally, its apoptosis-inducing activity was further validated through activation of BAX and caspase-9, and inhibition of BCL2 levels. In silico molecular docking experiments revealed a good binding mode profile of the isolates towards Ras activation/pathway mitogen-activated protein kinase (Ras/MAPK); a common molecular pathway in the development and progression of liver tumors.
Open AccessNew Antiproliferative Triflavanone from Thymelaea hirsuta—Isolation, Structure Elucidation and Molecular Docking Studies
In this study isolates from Thymelaea hirsuta, a wild plant from the Sinai Peninsula of Egypt, were identified and their selective cytotoxicity levels were evaluated. Phytochemical examination of the ethyl acetate (EtOAc) fraction of the methanolic (MeOH) extract of the plant led to the isolation of a new triflavanone compound (1), in addition to the isolation of nine previously reported compounds. These included five dicoumarinyl ethers found in Thymelaea: daphnoretin methyl ether (2), rutamontine (3), neodaphnoretin (4), acetyldaphnoretin (5), and edgeworthin (6); two flavonoids: genkwanin (7) and trans-tiliroside (8); p-hydroxy benzoic acid (9) and β sitosterol glucoside (10). Eight of the isolated compounds were tested for in vitro cytotoxicity against Vero and HepG2 cell lines using a sulforhodamine-B (SRB) assay. Compounds 1, 2 and 5 exhibited remarkable cytotoxic activities against HepG2 cells, with IC50 values of 8.6, 12.3 and 9.4 μM, respectively, yet these compounds exhibited non-toxic activities against the Vero cells. Additionally, compound 1 further exhibited promising cytotoxic activity against both MCF-7 and HCT-116 cells, with IC50 values of 4.26 and 9.6 μM, respectively. Compound 1 significantly stimulated apoptotic breast cancer cell death, resulting in a 14.97-fold increase and arresting 40.57% of the cell population at the Pre-G1 stage of the cell cycle. Finally, its apoptosis-inducing activity was further validated through activation of BAX and caspase-9, and inhibition of BCL2 levels. In silico molecular docking experiments revealed a good binding mode profile of the isolates towards Ras activation/pathway mitogen-activated protein kinase (Ras/MAPK); a common molecular pathway in the development and progression of liver tumors.