Rachel Price
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Rachel Price has a total of 2 co-authors. Here are the top co-authors by number of shared publications:
- Ada Ledonne
Fondazione Santa Lucia IRCCS, Department of Experimental Neuroscience, Rome, Italy; University of Rome Tor Vergata, Department of Systems Medicine, Rome, Italy
1 shared publication - Nicola Biagio Mercuri
Unit of Neurology, Department of Systems Medicine Tor Vergata University of Rome Rome Italy
1 shared publication
Latest Publications
- Open Access
- 16 January 2021
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 22 (2) , 869
Emerging Roles of Protease-Activated Receptors (PARs) in the Modulation of Synaptic Transmission and Plasticity
Protease-activated receptors (PARs) are a class of G protein-coupled receptors (GPCRs) with a unique mechanism of activation, prompted by a proteolytic cleavage in their N-terminal domain that uncovers a tethered ligand, which binds and stimulates the same receptor. PARs subtypes (PAR1-4) have well-documented roles in coagulation, hemostasis, and inflammation, and have been deeply investigated for their function in cellular survival/degeneration, while their roles in the brain in physiological conditions remain less appreciated. Here, we describe PARs’ effects in the modulation of neurotransmission and synaptic plasticity. Available evidence, mainly concerning PAR1-mediated and PAR2-mediated regulation of glutamatergic and GABAergic transmission, supports that PARs are important modulators of synaptic efficacy and plasticity in normal conditions.
- 16 January 2021
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 22 (2) , 869
Open AccessEmerging Roles of Protease-Activated Receptors (PARs) in the Modulation of Synaptic Transmission and Plasticity
Protease-activated receptors (PARs) are a class of G protein-coupled receptors (GPCRs) with a unique mechanism of activation, prompted by a proteolytic cleavage in their N-terminal domain that uncovers a tethered ligand, which binds and stimulates the same receptor. PARs subtypes (PAR1-4) have well-documented roles in coagulation, hemostasis, and inflammation, and have been deeply investigated for their function in cellular survival/degeneration, while their roles in the brain in physiological conditions remain less appreciated. Here, we describe PARs’ effects in the modulation of neurotransmission and synaptic plasticity. Available evidence, mainly concerning PAR1-mediated and PAR2-mediated regulation of glutamatergic and GABAergic transmission, supports that PARs are important modulators of synaptic efficacy and plasticity in normal conditions.