TimirY Mehta
Research Subjects
Research Interests
TimirY Mehta has a total of 13 co-authors. Here are the top co-authors by number of shared publications:
- Bharti Mittal
Pirbright England GU240NF Pirbright Institute
1 shared publication - Chaitanya G. Joshi
Gujarat Biotechnology Research Centre (GBRC), Department of Science and Technology, Government of Gujarat, Gandhinagar, India
1 shared publication Dave Dm
1 shared publicationDineshB Patel
1 shared publicationDinkarM Dave
1 shared publicationGoyal Rk
1 shared publication
Latest Publications
- Open Access
- 1 January 2009
- Published by Scientific Scholar in Indian Journal of Dermatology, Venereology and Leprology
- Vol. 75 (6) , 579-82
Association of HLA-BFNx011502 allele and carbamazepine-inducedStevens-Johnson syndromeamong Indians
Background: Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis are severe cutaneous reactions caused by certain drugs, including antiepileptic carbamazepine. A strong association has been reported between human leucocyte antigen (HLA)-B*1502 and carbamazepine-induced SJS in Han Chinese patients. European studies suggested that HLA-B*1502 is not a universal marker but is ethnicity-specific for Asians. Aim: To study the association between HLA-B*1502 and carbamazepine-induced SJS in Indian patients. Methods: Eight individuals who fulfilled the diagnostic criteria of SJS induced by carbamazepine were identified and HLA-B molecular typing was performed. HLA-B genotyping was carried out by polymerase chain reaction using sequence-specific primers. Results: Out of eight patients studied for genotype, six patients were found to have the HLA-B*1502 allele. Conclusion: This study suggests an association between HLA-B*1502 and carbamazepine-induced SJS in Indian patients.
- 1 January 2009
- Published by Scientific Scholar in Indian Journal of Dermatology, Venereology and Leprology
- Vol. 75 (6) , 579-82
Open AccessAssociation of HLA-BFNx011502 allele and carbamazepine-inducedStevens-Johnson syndromeamong Indians
Background: Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis are severe cutaneous reactions caused by certain drugs, including antiepileptic carbamazepine. A strong association has been reported between human leucocyte antigen (HLA)-B*1502 and carbamazepine-induced SJS in Han Chinese patients. European studies suggested that HLA-B*1502 is not a universal marker but is ethnicity-specific for Asians. Aim: To study the association between HLA-B*1502 and carbamazepine-induced SJS in Indian patients. Methods: Eight individuals who fulfilled the diagnostic criteria of SJS induced by carbamazepine were identified and HLA-B molecular typing was performed. HLA-B genotyping was carried out by polymerase chain reaction using sequence-specific primers. Results: Out of eight patients studied for genotype, six patients were found to have the HLA-B*1502 allele. Conclusion: This study suggests an association between HLA-B*1502 and carbamazepine-induced SJS in Indian patients.