Yutian Luo
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Yutian Luo has a total of 7 co-authors. Here are the top co-authors by number of shared publications:
- Bingbing Qiao
The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China
1 shared publication - Haiming Zhang
Beijing Friendship Hospital, Capital Medical University, Beijing, China
1 shared publication - Hongwei Xu
Department of Hepatobiliary Surgery First Affiliated Hospital of Xinxiang Medical University Xinxiang China
1 shared publication - Jiaxing Yang
Department of Radiology Changzhou Second People's Hospital Changzhou China
1 shared publication - Jindan He
Department of Anesthesiology Peking University Third Hospital Beijing China
1 shared publication - Shipeng Li
Department of Hepatopancreaticobiliary Surgery, Henan Provincial People's Hospital, Zhengzhou University, Zhengzhou, Henan, China
1 shared publication
Latest Publications
- Open Access
Autophagic activation of IRF‐1 aggravates hepatic ischemia–reperfusion injury via JNK signaling
Increasing evidence has accrued indicating that autophagy is associated with hepatic ischemia–reperfusion injury (IRI). This report demonstrates that interferon regulatory factor‐1 (IRF‐1) was upregulated in response to hepatic IRI and was associated with autophagic activation. As a result of these processes, there is an aggravation of liver damage, effects that can be offset by IRF‐1 depletion. In addition, these effects of IRF‐1 are associated with JNK pathway activation followed by increases in Beclin1 protein levels. This JNK‐induced autophagic cell death then leads to cell failure, and plays an important role in liver function damage. We conclude that IRF‐1 activates autophagy through JNK‐mediated autophagy. Accordingly, these findings indicating that the IRF‐1/JNK pathway activates autophagy to exacerbate liver IRI in this mouse model may provide new insights into novel protective therapies for hepatic IRI.
Open AccessAutophagic activation of IRF‐1 aggravates hepatic ischemia–reperfusion injury via JNK signaling
Increasing evidence has accrued indicating that autophagy is associated with hepatic ischemia–reperfusion injury (IRI). This report demonstrates that interferon regulatory factor‐1 (IRF‐1) was upregulated in response to hepatic IRI and was associated with autophagic activation. As a result of these processes, there is an aggravation of liver damage, effects that can be offset by IRF‐1 depletion. In addition, these effects of IRF‐1 are associated with JNK pathway activation followed by increases in Beclin1 protein levels. This JNK‐induced autophagic cell death then leads to cell failure, and plays an important role in liver function damage. We conclude that IRF‐1 activates autophagy through JNK‐mediated autophagy. Accordingly, these findings indicating that the IRF‐1/JNK pathway activates autophagy to exacerbate liver IRI in this mouse model may provide new insights into novel protective therapies for hepatic IRI.