Gregory Kurgansky

Epilepsy is one of the most common neurological disorders globally, affecting about 50 million people, with nearly 80% of those affected residing in low- and middle-income countries. It is characterized by recurrent seizures that result from abnormal electrical brain activity, with seizures varying widely in manifestation. The exploration of the biomechanical effects that seizures have on brain dynamics and stress levels is relevant for the development of more effective treatments and protective strategies. This study uses a blend of experimental data and computational simulations to assess the brain’s physical response during seizures, particularly focusing on the behavior of cerebrospinal fluid and the resulting mechanical stresses on different brain regions. Notable findings show increases in stress, predominantly in the posterior gyri and brainstem, during seizures and an evidence of brain displacement relative to the skull. These observations suggest a dynamic and complex interaction between the brain and skull, with maximum shear stress regions demonstrating the limited yet essential protective role of the CSF. By providing a deeper understanding of the mechanical changes occurring during seizures, this research supports the goal of advancing diagnostic tools, informing more targeted treatment interventions, and guiding the creation of customized therapeutic strategies to enhance neurological care and protect against the adverse effects of seizures.

In the field of modern healthcare, technology plays a crucial role in improving patient care and ensuring their safety. One area where advancements can still be made is in alert systems, which provide timely notifications to hospital staff about critical events involving patients. These early warning systems allow for swift responses and appropriate interventions when needed. A commonly used patient alert technology is nurse call systems, which empower patients to request assistance using bedside devices. Over time, these systems have evolved to include features such as call prioritization, integration with staff communication tools, and links to patient monitoring setups that can generate alerts based on vital signs. There is currently a shortage of smart systems that use sensors to inform healthcare workers about the activity levels of patients who are confined to their beds. Current systems mainly focus on alerting staff when patients become disconnected from monitoring machines. In this technical note, we discuss the potential of utilizing cost-effective sensors to monitor and evaluate typical movements made by hospitalized bed-bound patients. To improve the care provided to unaware patients further, healthcare professionals could benefit from implementing trigger alert systems that are based on detecting patient movements. Such systems would promptly notify mobile devices or nursing stations whenever a patient displays restlessness or leaves their bed urgently and requires medical attention.

Due to the inherent complexity of biological applications that more often than not include fluids and structures interacting together, the development of computational fluid–structure interaction models is necessary to achieve a quantitative understanding of their structure and function in both health and disease. The functions of biological structures usually include their interactions with the surrounding fluids. Hence, we contend that the use of fluid–structure interaction models in computational studies of biological systems is practical, if not necessary. The ultimate goal is to develop computational models to predict human biological processes. These models are meant to guide us through the multitude of possible diseases affecting our organs and lead to more effective methods for disease diagnosis, risk stratification, and therapy. This review paper summarizes computational models that use smoothed-particle hydrodynamics to simulate the fluid–structure interactions in complex biological systems.