Jordan C Ciciliano
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Jordan C Ciciliano has a total of 5 co-authors. Here are the top co-authors by number of shared publications:
- Brian P. Johnson
Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, USA
1 shared publication - David J. Beebe
Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, USA
1 shared publication - Elaine T. Alarid
McArdle Laboratory for Cancer Research, Department of Oncology, Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, Madison, WI 53705, USA
1 shared publication - Linda A. Schuler
Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706, USA
1 shared publication - Molly M. Morgan
Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, USA
1 shared publication
Latest Publications
- 1 February 2020
- Published by Oxford University Press (OUP) in Integrative Biology
- Vol. 12 (2) , 21-33
Modeling chemical effects on breast cancer: the importance of the microenvironment in vitro
Accumulating evidence suggests that our ability to predict chemical effects on breast cancer is limited by a lack of physiologically relevant in vitro models; the typical in vitro breast cancer model consists of the cancer cell and excludes the mammary microenvironment. As the effects of the microenvironment on cancer cell behavior becomes more understood, researchers have called for the integration of the microenvironment into in vitro chemical testing systems. However, given the complexity of the microenvironment and the variety of platforms to choose from, identifying the essential parameters to include in a chemical testing platform is challenging. This review discusses the need for more complex in vitro breast cancer models and outlines different approaches used to model breast cancer in vitro. We provide examples of the microenvironment modulating breast cancer cell responses to chemicals and discuss strategies to help pinpoint what components should be included in a model.
- 1 February 2020
- Published by Oxford University Press (OUP) in Integrative Biology
- Vol. 12 (2) , 21-33
Modeling chemical effects on breast cancer: the importance of the microenvironment in vitro
Accumulating evidence suggests that our ability to predict chemical effects on breast cancer is limited by a lack of physiologically relevant in vitro models; the typical in vitro breast cancer model consists of the cancer cell and excludes the mammary microenvironment. As the effects of the microenvironment on cancer cell behavior becomes more understood, researchers have called for the integration of the microenvironment into in vitro chemical testing systems. However, given the complexity of the microenvironment and the variety of platforms to choose from, identifying the essential parameters to include in a chemical testing platform is challenging. This review discusses the need for more complex in vitro breast cancer models and outlines different approaches used to model breast cancer in vitro. We provide examples of the microenvironment modulating breast cancer cell responses to chemicals and discuss strategies to help pinpoint what components should be included in a model.