ANAkhtaeva N.

Akhtaeva N.

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Akhtaeva N. has a total of 24 co-authors. Here are the top co-authors by number of shared publications:


Latest Publications

  • Open Access

    TRENDS IN MORBIDITY AND MORTALITY FROM CHRONIC HEART FAILURE IN ALMATY

    by Akhmetzhan A.D., Zhakyp N., Fayzullina K.M., Dosbayeva D.ZH., Akhtaeva N., Imamatdinova A.M.

    Ntroduction. Heart failure (HF) is a significant public health problem, especially in the context of increasing life expectancy and an aging population. Data provided by the European Society of Cardiology shows a median prevalence of HF in 2019 of 17 cases per 1,000 people, with differences across countries. There is also an increase in the number of cases of cardiovascular diseases in Kazakhstan. Aim. To analyze the incidence of diseases and the death rate from chronic heart failure (CHF) in the city of Almaty. Materials and methods. A retrospective study was conducted. We analyzed the incidence and mortality from CHF in Almaty from 2013 to 2022 based on data provided by the National Scientific Center for Health Development, a branch in Almaty. CHF mortality was predicted for the next five years using the TREND function in Excel. We also used a natural logarithmic linear model to analyze the constant percentage change in velocity over time. A p value of less than 0.05 is considered statistically significant. Results. A study of the incidence and mortality from CHF in Almaty from 2013 to 2023 revealed an increase in the incidence from 9885 to 15332 cases, reaching a peak decrease in 2015 to 7748. While the death rate decreased from 6.5 to 3.0 per 100,000 population. The forecast for the next five years shows the likelihood of a further increase in morbidity. The number of patients registered at the dispensary with congestive heart failure has increased from 232 to 7160, and further growth is expected by 2027. There is also an increase in treated cases. Conclusion. A further increase in the incidence and mortality from CHF is predicted in the next five years, which underscores the need to implement cardiorehabilitation programs involving multidisciplinary teams and patient-centered care principles to improve the quality of life of patients with CHF. Working to reduce risk factors such as alcohol consumption, smoking, and improved nutrition, with the participation of all stakeholders, contributes to improving performance. Введение. Сердечная недостаточность (СН) представляет собой значительную проблему в сфере общественного здравоохранения, особенно в контексте увеличения продолжительности жизни и старения населения. Данные, представленные Европейским обществом кардиологов, показывают медианную распространенность СН в 2019 году, составляющую 17 случаев на 1000 человек, с различиями в разных странах. В Казахстане также отмечается увеличение числа случаев сердечно-сосудистых заболеваний. Цель. Анализ частоты заболеваний и уровня смертности от хронической сердечной недостаточности (ХСН) в городе Алматы. Материалы и методы. Было проведено ретроспективное исследование. Мы анализировали заболеваемость и смертность от ХСН в городе Алматы с 2013 по 2022 годы на основе данных, предоставленных Национальным научным центром развития здравоохранения, филиалом в г. Алматы. Был проведен анализ прогнозирования смертности от ХСН на следующие пять лет с использованием функции TREND в Excel. Мы также использовали естественную логарифмическую линейную модель для анализа постоянного процентного изменения скорости с течением времени. Значение p менее 0,05 считается статистически значимым. Результаты. В ходе исследования заболеваемости и смертности от ХСН в городе Алматы с 2013 по 2023 год выявлен рост заболеваемости с 9885 до 15332 случаев, достигнув пика снижения в 2015 году до 7748. Тогда как показатель смертности снизился с 6,5 до 3,0 на 100 000 населения. Прогноз на следующие пять лет показывает вероятность дальнейшего увеличения заболеваемости. Количество пациентов, находящихся на диспансерном учете с застойной сердечной недостаточностью, увеличилось с 232 до 7160, ожидается дальнейший рост к 2027 году. Отмечается также рост пролеченных случаев. Выводы. Прогнозируется дальнейший рост заболеваемости и смертности от ХСН в ближайшие пять лет, что подчеркивает необходимость внедрения кардиореабилитационных программ с участием мультидисциплинарных команд и принципов пациентоориентированной помощи для улучшения качества жизни пациентов с ХСН. Работа по снижению факторов риска, таких как употребление алкоголя, курение, и улучшение питания, с участием всех заинтересованных...


  • Open Access

    UNDERSTANDING AUTISM SPECTRUM DISORDERS AMONG THE POPULATION OF KAZAKHSTAN

    by Kosherbayeva L., Kurmanalina S., Akhtaeva N., Samambayeva A., Altynbekov K.

    Background: Autism spectrum disorders (ASD) associated with neurodevelopmental condition characterized with repetitive behaviors, lack of social communication. The annual increase in ASD indicates the need to increase awareness of ASD among the population in order to reduce stigma, as well as among parents of early recognition of the first symptoms of ASD. The aim of our study to identify the perception of population about ASD. Methods: We developed a questionnaire in both Kazakh and Russian languages based on a comprehensive literature review. The survey was conducted across all regions of Kazakhstan using a Google Form, which was distributed through specialists in primary health care and parent groups with children diagnosed with ASD. A total of 410 respondents aged 18 years and above voluntarily participated in the survey. The collected data underwent statistical analyses using MS Excel and SPSS13. Results: The survey primarily attracted participants aged 25 to 54 years. This may indicate that information about the prevalence of autism and organizations dealing with this issue is not widely disseminated among other age groups. The overwhelming majority of respondents were unaware of the prevalence of autism in Kazakhstan. This suggests that awareness about this issue remains low and requires additional education and information dissemination efforts. Despite limited awareness of the prevalence, respondents observed a growth in autism cases. This might be a sign of increasing awareness about the issue, but the lack of specific information about its scale could be a concern. Respondents also demonstrated limited knowledge about the nature of autism and organizations working in this field. Conclusion: There is a pressing need to carry out awareness-raising initiatives among the general population regarding autism and its characteristics, as well as providing essential support to parents and caregivers of children with ASD. Введение. Расстройства аутистического спектра (РАС), связаны с нарушением развития нервной системы и характеризуются повторяющимся поведением, недостатком социального общения. Ежегодный рост распространения аутизма (РАС) свидетельствует о необходимости повышения информированности населения об этом расстройстве с целью снижения стигматизации и обеспечения раннего выявления первых симптомов у детей. Наше исследование направлено на выявление отношения общества к аутизму, а также на оценку уровня информированности населения о данном расстройстве. Методы. На основе обзора литературы была разработана анкета на казахском и русском языках. Опрос проводился во всех регионах Казахстана с использованием google-формы, которая рассылалась по почте через специалистов первичного звена здравоохранения, группы родителей с детьми с РАС. В опросе добровольно приняли участие 410 респондентов в возрасте от 18 лет и старше. Статистический анализ проводился с использованием MS Excel и SPSS13. Результаты. Опрос привлек в основном респондентов возрастом от 25 до 54 лет. Это может указывать на то, что информация о распространенности аутизма и организациях, занимающихся этой проблемой, недостаточно распространена среди других возрастных групп. Подавляющее большинство респондентов не имели представления о распространенности аутизма в Казахстане. Это может указывать на то, что осведомленность о данной проблеме остается низкой и требует дополнительного просвещения и информационной работы. Несмотря на низкую осведомленность о распространенности, респонденты отмечают рост аутизма. Респонденты также проявили недостаточную осведомленность о том, как проявляется аутизм, и об организациях, которые работают в этой области. Вывод. Необходима реализация мероприятий по повышению осведомленности населения об аутизме и его течении, а также о том, как оказать поддержку родителям и опекунам детей с РАС. Кіріспе. Аутизм спектрінің бұзылуы (АСБ) жүйке жүйесінің дамуының бұзылуымен байланысты және қайталанатын мінез-құлықпен, әлеуметтік қарым-қатынастың болмауымен сипатталады. Аутизмнің таралуының жыл сайынғы өсуі (рет) стигматизацияны азайту және балалардағы алғашқы белгілерді ерте анықтауды...


  • Open Access

    TREATABLE MORTALITY IN GENITOURINARY SYSTEM DISEASE

    by Kosherbayeva L., Samambayeva A., Akhtaeva N., Tolganbayeva K., Imamatdinova A.

    Introduction: In recent years there has been an increase of the genitourinary system disease. For instance, according to the Global Burden of Disease data in 2019 about 404.61 million cases registered and 236,790 deaths. In addition, between 1990 to 2019, the mortality rate increased 2.4 times where the age-standardized death rate rose from 2.77 to 3.13 per 100,000 population. The aim of our study to calculate the treatable mortality from genitourinary system disease in Kazakhstan. Methods: The mortality data from genitourinary system disease was obtained from the Bureau of National Statistics of the Agency for Strategic Planning and Reforms of the Republic of Kazakhstan (https://stat.gov.kz). The data was generated based on criteria and indicators developed by countries of the Organization for Economic Co-operation and Development (OECD), which include: the number of deaths by age categories and causes of death. Data presented for the period from 2015 to 2021, disaggregated by the age group of 5 years. Results: Treatable mortality from renal failure in the whole of the Kazakhstan increased from 6.76 to 11.14 per 100,000 population, in particular, the growth was more than three times higher in 2021 compared to 2015 in in six regions of Kazakhstan. In Kazakhstan, the high rate of treatable mortality from renal failure in 2021 was within 10 or more per 100,000 of the population in nine regions. Conclusion: An analysis of international studies shows an increase in the burden of diseases from genitourinary system, therefore, there is a need to improve prevention and treatment activities, especially in regions where there is an increase in treatable deaths. Введение. В последние годы отмечается рост заболеваний мочеполовой системы. Например, согласно данным Global Burden of Disease, в 2019 году было зарегистрировано около 404,61 миллиона случаев заболевания и 236 790 смертей. Кроме того, в период с 1990 по 2019 год уровень смертности увеличился в 2,4 раза, при этом стандартизованный по возрасту коэффициент смертности вырос с 2,77 до 3,13 на 100 000 населения. Целью нашего исследования рассчитать излечимую смертность от болезней мочеполовой системы в Казахстане. Методы. Статистические данные были получены в Бюро Национальной статистики Агентства по стратегическому планированию и реформам Республики Казахстан (https://stat.gov.kz). Данные были сформированы на основании критериев и индикаторов, разработанных Организацией экономического сотрудничества и развития (ОЭСР), которые включают: количество смертей в разрезе возрастных категорий и причин смерти в Республике Казахстан и области. Данные представлены за период с 2015 по 2021 год в разбивке возрастной группы по 5 лет. Результаты. Излечимая смертность от почечной недостаточности в целом по РК выросла с 6,76 на 11,14 на 100 000 населения, в частности рост был более чем в три раза выше в шести регионах Казахстана в 2021 году в сравнении с 2015 годом. По РК высокий показатель излечимой смертности от почечной недостаточности в 2021 году был в пределах 10 и выше на 100 000 населения в девяти регионах. Выводы. Анализ международных исследований показывает рост бремени от заболеваний мочеполовой системы, следовательно, наблюдается потребность в улучшении мероприятий по профилактике и лечению, особенно в регионах, где наблюдается рост излечимой смертности. Кіріспе. Соңғы жылдары несеп-жыныс жүйесі ауруларының өсуі байқалды. Мысалы, Global Burden of Disease мәліметтері бойынша, 2019 жылы шамамен 404,61 миллион жағдай және 236 790 адам қайтыс болды. Сонымен қатар, 1990-2019 жылдар аралығында өлім-жітім деңгейі 2,4 есе өсті, бұл ретте жас бойынша стандартталған өлім коэффициенті 100 000 тұрғынға шаққанда 2,77-ден 3,13-ке дейін өсті. Біздің зерттеуіміздің мақсаты Қазақстандағы несеп-жыныс жүйесі ауруларынан емделетін өлімді есептеу. Зерттеу әдістері. Статистикалық деректер Қазақстан Республикасы Стратегиялық жоспарлау және реформалар агенттігінің Ұлттық статистика бюросынан алынды (https://stat.gov.kz). Деректер Экономикалық ынтымақтастық және даму ұйымы (ЭЫДҰ) әзірлеген критерийлер мен индикаторлар негізінде...


  • Open Access

    Features of clinical manifestations, course, outcomes and health related quality of life in patients with systemic lupus erythematosus in the Republic of Kazakhstan

    by B. G. Issayeva, E. A. Aseeva, M. M. Saparbayeva, S. M. Issayeva, M. M. Kulshymanova, S. M. Kaiyrgali, A. S. Amanzholov, M. P. Bizhanova, M. B. Kalykova, S. K. Solovyev, et al.

    Objective – to evaluate the features of clinical manifestations, course, outcomes and quality of life related to health in patients with systemic lupus erythematosus in the Republic of Kazakhstan.Patients and methods. The study included 102 patients with systemic lupus erythematosus (SLE) with a reliable diagnosis according to SLICC (2012). Disease activity was assessed by the SLEDAI 2K index, organ damage (IOD) by SLICC/ACR (2000). Statistical processing was carried out using SPSS 13 software (IBM Corp., USA). Variables with a parametric distribution are presented as М±SD, nonparametric – as a median (Me) [25th; 75th percentile].Results and discussion. The cohort was dominated by female patients (98%), Asians (83.33%), young patients (33.85±10.58 years) with a disease duration of 5 [2; 9] years with high (30.8%) and very high (39.2%) degree of activity (SLEDAI-2K – 17.64±8.80 points). The debut of the disease was in 18.6% of patients in adolescence, it was characterized by an unfavorable course. Clinical manifestations of the disease: skin lesions (acute active and chronic forms) (98%), joints (79.4%), non-scarring alopecia (75.5%), neuropsychiatric disorders (49%), mucous membranes (46.1%), hematological (54.9%) and immunological disorders (100%). IOD: low – in 20.6%, medium – in 59.8%, high – in 9.8% of patients, 0 – in 9.8%, Risk factors for poor outcome were in 93.1% of patients. Assessment of health-related quality of life (HRQOL) in SLE patients showed a significant decrease on all scales. Correction of the treatment program, taking into account the factors of adverse outcome (FRNI), consisted in strengthening therapy with the inclusion of genetically engineered biological drugs (GEBP).Conclusion. SLE is a socially significant disease in Kazakhstan with a high incidence rate (101%) over 10 years (2009–2018). The cohort of SLE patients is dominated by young people, females. The duration of the disease is up to 5 years with a delayed verification of the diagnosis of SLE. Organ damage is already in the onset of the disease and the presence of FRNI of the disease in 93.1% of patients, which indicates the severity of the course, which requires early diagnosis and active involvement of pathogenetic treatment, including GEBD.


  • Open Access

    Epidemiological, demographic, social, clinical features of manifestations of system red lupus in patients in Kazakhstan

    by B. G. Issayeva, E. A. Aseeva, M. M. Saparbayeva, S. M. Issayeva, M. M. Kulshymanova, S. M. Kaiyrgali, M. P. Bizhanova, K. Zh. Nurgaliyev, N. S. Akhtaeva, B. A. Kulymbetova, et al.

    Objective: to study and analyze the dynamics of prevalence, demographic, social, and clinical manifestations of systemic lupus erythematosus (SLE) in patients living in Kazakhstan.Materials and methods. Official materials of the Ministry of Health of the Republic of Kazakhstan (2009–2018): statistical compendiums, a consolidated reporting form for medical treatment (N 12). 102 patients (100 women and 2 men) were included in the register of SLE with reliable SLE according to SLICC (ACR, 2012). Assessment of the debut of the disease was carried out according to archival material (medical history, outpatient records) of patients. The activity of the process was evaluated according to SLEDAI-2K, organ damage according to SLICC/ACR (2000).Results. The total number of patients with SLE over 10 years (2009–2018) more than doubled, the growth rate was 101%. The overwhelming majority of patients with SLE are women (91%). In the study group, Asians (83.33%) predominated by race, of which Kazakhs (76.47%) were young (mean age – 33.85±10.58 years), with a disease duration of 5 (2; 9) years, time from the appearance of the first signs to verification of SLE – 4.5 (3; 12) years. The prevailing acute (49.0%), subacute (33.3%), rather than chronic (18.7%) variants of the course, with high activity according to SLEDAI-2K – 17.64±8.80. The most common clinical manifestations of the disease: skin lesions (98%), joints (79.4%), nervous system (49%), hematological (54.9%) and immunological (100%) disorders. The absence of organ damage (0 points) was detected in 10 (9.8%) cases, low (1 point) – in 21 (20.6%), medium (2–4) – in 61 (59.8%), high (over 4) – in 10 (9.8%) patients.Conclusion. SLE remains a socially significant disease in Kazakhstan, as evidenced by the dynamics of the increase in incidence (101%) over 10 years (2009–2018). The prevalence of SLE is 24.7 per 100 thousand of the country’s population, lower than in other countries with a predominant Asian population or in comparison with Asian populations. A cohort of patients with SLE was represented by people of the Asian race (83.33%), Kazakhs (76.47%), and young people (33.85±10.58). The analysis revealed a delayed verification of the diagnosis of SLE (on average 4.5 (3; 12) years). Acute variants of the course of the disease with high disease activity according to SLEDAI-2K prevail. Common clinical manifestations of SLE are skin lesions, both acute and chronic (98%), joints (79.4%), damage to the nervous system (49%), hematological (54.9%) and immunological disorders (100%).