Fengchun Zhang
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Fengchun Zhang has a total of 18 co-authors. Here are the top co-authors by number of shared publications:
Chaojun Hu
Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China
2 shared publications- Yongzhe Li
Department of Clinical Laboratory, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China
2 shared publications - Changqing Zeng
CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing, China
1 shared publication - Chaohua Li
Morehouse School of Medicine, Atlanta, GA, USA
1 shared publication - Chenxi Liu
Peking Union Medical College Hospital
1 shared publication - Chunwei Cao
Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Medical Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China
1 shared publication
Latest Publications
- Open Access
- 1 January 2021
- Published by Elsevier in Molecular & Cellular Proteomics
- Vol. 20, 100036
Identification of Novel Serological Autoantibodies in Takayasu Arteritis Patients Using HuProt Arrays
- 1 January 2021
- Published by Elsevier in Molecular & Cellular Proteomics
- Vol. 20, 100036
Open AccessIdentification of Novel Serological Autoantibodies in Takayasu Arteritis Patients Using HuProt Arrays
- 22 January 2011
- Published by Springer Nature in Rheumatology International
- Vol. 32 (5) , 1251-1255
A single-nucleotide polymorphism of the STAT4 gene is associated with systemic lupus erythematosus (SLE) in female Chinese population
Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease with complex genetic inheritance. Genetic association of signal transducer and activator of transcription 4 (STAT4) with SLE susceptibility has been convincingly established in multiple populations including Asians, whereas studies of genetic relations between STAT4 polymorphisms and subphenotypes of SLE were rarely conducted. In this study, we selected Chinese female population and investigated genetic association between a polymorphism of STAT4 gene (rs7582694) and SLE. Furthermore, genetic association tests based on different subsets classified by 11 clinical manifestations were also performed. A total of 675 SLE female patients and 678 healthy controls were enrolled into this study, and SNP genotyping was performed using Sequenom’s MassArray system (Sequenom iPLEX assay). Our study showed strong evidence for genetic predisposition of rs7582694 to SLE (X 2 = 23.7, OR = 0.68, 95% CI: 0.58–0.79, P = 1.13 × 10−6), while no association was observed between rs7582694 and any clinical presentations. The results of our study demonstrated that STAT4 rs7582694 SNP was significantly associated with SLE, and these results were in accordance with previous studies.
- 22 January 2011
- Published by Springer Nature in Rheumatology International
- Vol. 32 (5) , 1251-1255
A single-nucleotide polymorphism of the STAT4 gene is associated with systemic lupus erythematosus (SLE) in female Chinese population
Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease with complex genetic inheritance. Genetic association of signal transducer and activator of transcription 4 (STAT4) with SLE susceptibility has been convincingly established in multiple populations including Asians, whereas studies of genetic relations between STAT4 polymorphisms and subphenotypes of SLE were rarely conducted. In this study, we selected Chinese female population and investigated genetic association between a polymorphism of STAT4 gene (rs7582694) and SLE. Furthermore, genetic association tests based on different subsets classified by 11 clinical manifestations were also performed. A total of 675 SLE female patients and 678 healthy controls were enrolled into this study, and SNP genotyping was performed using Sequenom’s MassArray system (Sequenom iPLEX assay). Our study showed strong evidence for genetic predisposition of rs7582694 to SLE (X 2 = 23.7, OR = 0.68, 95% CI: 0.58–0.79, P = 1.13 × 10−6), while no association was observed between rs7582694 and any clinical presentations. The results of our study demonstrated that STAT4 rs7582694 SNP was significantly associated with SLE, and these results were in accordance with previous studies.