Guglielmo Paganetto
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Guglielmo Paganetto has a total of 9 co-authors. Here are the top co-authors by number of shared publications:
- Alessandra Guerrini
Technopole Terra&Acqua Tech (Research Unit 7), Department of Life Sciences and Biotechnology, University of Ferrara, 44121 Ferrara, Italy
1 shared publication - Alessandro Grandini
Department of Life Sciences and Biotechnology, University of Ferrara, Via L. Borsari 46, 44121 Ferrara, Italy
1 shared publication - Arianna Marengo
Department of Drug Science and Technology, University of Turin, via Pietro Giuria 9, 10125 Turin, Italy
1 shared publication - Gianni Sacchetti
Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy
1 shared publication - Immacolata Maresca
Department of Life Sciences and Biotechnology, Section of Pharmaceutical Biology, University of Ferrara, Piazzale Luciano Chiappini 3, Malborghetto di Boara, FE I-44123,Italy
1 shared publication - Luciano Di Martino
Majella Seed Bank-Parco Nazionale della Majella, Via Badia 28, 67039 Sulmona, Italy
1 shared publication
Latest Publications
- Open Access
Wild Italian Hyssopus officinalis subsp. aristatus (Godr.) Nyman: From Morphological and Phytochemical Evidences to Biological Activities
Three specimens of H. officinalis subsp. aristatus were collected in three areas of the Abruzzo region (Italy) and subjected to macroscopic and microscopic observation to support their botanical identification. The essential oils (EOs) obtained from the aerial parts of the samples were characterized with the object to define their phytochemical and pharmaceutical biology profile. They highlight three different chemotypes, including one never seen in previous literature (CIV17-EO, distilled from sample harvested in 2017 at Civitaretenga), that showed a fingerprinting with the predominance of (-)-limonen-10-yl-acetate (67.9%). In 2017 European Food Safety Authority (EFSA) reported the genotoxicity of similar compounds, therefore, to dismiss any safety concern for the CIV17-EO use as flavouring substance, the Ames test was performed with no evidence of mutagenic activity. Safety of use coupled with chemical characterization of this new chemotype set the stage for a better standardization of H. officinalis EOs. The ethanolic extracts, on the other hand, with qualitatively similar chemical profiles in which caftaric, chlorogenic and rosmarinic acid were the main molecules, showed interesting antioxidant activity and a slight cytotoxicity towards the A549 cell line that could indicate a starting point for the evaluation of an additional preventive tool for maintaining health status.
Open AccessWild Italian Hyssopus officinalis subsp. aristatus (Godr.) Nyman: From Morphological and Phytochemical Evidences to Biological Activities
Three specimens of H. officinalis subsp. aristatus were collected in three areas of the Abruzzo region (Italy) and subjected to macroscopic and microscopic observation to support their botanical identification. The essential oils (EOs) obtained from the aerial parts of the samples were characterized with the object to define their phytochemical and pharmaceutical biology profile. They highlight three different chemotypes, including one never seen in previous literature (CIV17-EO, distilled from sample harvested in 2017 at Civitaretenga), that showed a fingerprinting with the predominance of (-)-limonen-10-yl-acetate (67.9%). In 2017 European Food Safety Authority (EFSA) reported the genotoxicity of similar compounds, therefore, to dismiss any safety concern for the CIV17-EO use as flavouring substance, the Ames test was performed with no evidence of mutagenic activity. Safety of use coupled with chemical characterization of this new chemotype set the stage for a better standardization of H. officinalis EOs. The ethanolic extracts, on the other hand, with qualitatively similar chemical profiles in which caftaric, chlorogenic and rosmarinic acid were the main molecules, showed interesting antioxidant activity and a slight cytotoxicity towards the A549 cell line that could indicate a starting point for the evaluation of an additional preventive tool for maintaining health status.