João Pedro Vasconcelos Paolinelli

Objectives: To map and analyze scientific publications on pharmaceutical clinical services for self-limiting health conditions. Methods: Bibliometric review of Web of Science and Scopus records, using established scoping-review methodology, analyzed in Bibliometrix. Key findings: One hundred and two articles (1983–2024) were included; output has grown over time, concentrated in the last decade. The UK (14.4%), Australia (9.8%), and Canada (6.8%) accounted for the largest shares of publications; output was concentrated among a small number of institutions and authors. Conclusions: Scientific output remains concentrated in high-income countries; expanding research and implementation in low- and middle-income countries is needed.

Background: Although the role of pharmacists in pediatric oncology is well established, scientific production explicitly characterizing the services provided in this field remains limited. Objective: To map studies on pharmaceutical services in pediatric oncology. Methods: A scoping review was conducted in accordance with the JBI Manual for Evidence Synthesis and reported following the PRISMA-ScR Checklist. A systematic search was performed in September 2024 across six electronic databases, gray literature, and reference lists of selected studies. Eligible studies included original research and systematic reviews addressing pharmaceutical services in pediatric oncology. Two researchers independently assessed eligibility and extracted data, which were presented descriptively. Results: Twenty-two articles were included, of which 86.4% (n = 19) were conducted in countries with a very high or high Human Development Index (HDI). Most studies were carried out in hospitals (86.4%; n = 19), with inpatient care being the most frequently addressed setting (54.6%; n = 12). The pharmaceutical services described mainly focused on pharmacotherapy follow-up (46.4%), followed by prescription analysis (18.2%) and compounding of antineoplastic agents (18.2%). In 72.7% (n = 16) of the studies, services were offered in autonomy. Regarding outcomes, 68.2% (n = 15) focused on clinical endpoints. Observational studies predominated (91%; n = 20). Conclusion: The most frequently identified pharmaceutical services in pediatric oncology were pharmacotherapy follow-up, prescription analysis, and compounding of antineoplastic agents, generally provided autonomously within hospital and outpatient settings. These findings highlight the relevance of pharmacists’ role in this field while underscoring the need for more interventional studies evaluating clinical and economic outcomes.

Background: The implementation of pharmaceutical care (PC) in Primary Health Care (PHC) faces challenges related to interprofessional integration, management support, and infrastructure, despite its potential to improve patient-centered care. Objectives: To analyze, from the perspective of pharmacists working in PHC, the facilitating factors and barriers to the implementation of PC in the public health system in a post-implementation context. Methods: This is a qualitative, exploratory study, with eight individual semi-structured interviews conducted remotely between December 2024 and February 2025. The interviews were recorded, transcribed, and subjected to thematic content analysis by a trained team, with peer validation. Results: The main facilitators identified were: a solid relationship with the team, participation in continuing education, and a bond with patients. Barriers included a lack of adequate infrastructure, workload, staff turnover, and resistance from the health team. Management support, although frequently cited as a facilitator, did not always translate into concrete actions for service implementation. Even in the face of these barriers, the implementation of PC contributed to strengthening patient-centered care, the clinical protagonism of pharmacists, and improving health outcomes. Conclusions: The analysis highlighted that the sustainability of PC depends on structural and relational conditions that go beyond individual training. The study reveals that, after implementation and continuing education processes, organizational barriers persist that limit the consolidation of PC, highlighting the need for institutional policies and ongoing management support to effectively integrate pharmacists into healthcare.

Rationale: The implementation of Clinical Pharmacy Services in healthcare systems is multifactorial and complex. Some studies summarize the implementation research of these services in both outpatient and inpatient contexts. However, the literature lacks a comprehensive synthesis to understand how the implementation process occurs in Primary Health Care. Aim: To map, at an international level, the studies on the implementation of Clinical Pharmacy Services in Primary Health Care. Method: This scoping review followed the recommendations of the JBI Manual for Evidence Synthesis for Scoping Reviews. A systematic search was conducted in May 2023 across six electronic databases, grey literature, and the references of the selected studies. Original studies that described the implementation process of Clinical Pharmacy Services in Primary Health Care were eligible for inclusion. Two researchers independently assessed the studies based on eligibility criteria and extracted data from the selected articles. Data were presented descriptively. Results: A total of 97 studies were included, with 85.6% ( n = 83) conducted in developed countries. A significant emphasis was observed on qualitative and mixed‐methods research, accounting for 46.4% ( n = 45) of the studies. Only 22.7% ( n = 22) of the studies utilized theoretical models as research guides, while 96.9% ( n = 94), did not report on the implementation phase. Comprehensive Medication Management (36.8%, n = 35) was the most cited type of service. The most assessed implementation outcome was feasibility, at 73.2% ( n = 71). A total of 47.4% ( n = 46) assessed outcomes related to the implemented service, which included clinical, economic, and/or humanistic aspects. Conclusion: This study revealed numerous publications on the implementation of clinical services provided by pharmacists in primary care. These findings can guide future research on the implementation of these services and highlight the need for developing and underdeveloped countries to explore this topic further.

Objetivo: Mapear evidências científicas sobre as tecnologias em saúde da enfermagem na prevenção e controle da Hepatite A.

Objetivo: Mapear la evidencia científica sobre las tecnologías de salud de enfermería en la prevención y control de la Hepatitis A.

Objective: To map scientific evidence on nursing health technologies in the prevention and control of Hepatitis A.

Objective To identify and analyze the quality of scientific evidence from clinical efficacy studies present in the package inserts of coagulation factors, used in the treatment of hemophilia A and B. Methods Documentary study developed in two stages. The first stage consisted of identifying the medicine packages inserts electronically registered in the Brazilian Health Regulatory Agency, and analyzing the availability of the bibliographic references cited therein. This analysis was conducted in the PubMed, SciELO, Google Scholar, and Web of

Objective: to evaluate potential severe and moderate drug interactions in patients with chronic kidney disease (CKD) not on dialysis and using polypharmacy. Methodology: cross-sectional study carried out in a city in the center-west of Minas Gerais/Brazil. The population consisted of patients with non-dialysis kidney disease treated at the municipal nephrology clinic. Descriptive analysis was used to characterize the sociodemographic, clinical, and laboratory profile of the population. Bivariate logistic regression analysis was applied to determine factors associated with potential drug interactions. Variables with p-value < 0.20 were taken to the multivariate model. Results: Of the total of 75 participants, most were female, elderly and white. Among them, 60% (45/75) were in stage 3A and 3B of kidney disease. No significant association was found between the use of polypharmacy and Estimated Glomerular Filtration Rate (p Conclusions: high rates of moderate drug interactions were found, in addition to the presence of severe interactions. The association of multiple drugs in pharmacotherapy, especially for elderly patients with kidney disease, is often unavoidable and, therefore, deserves special attention not only from prescribing professionals but also from the entire team in order to safeguard the safety of these patients, avoiding events adverse events related to MIs.

Na literatura ainda são escassos os estudos que avaliam a qualidade dos medicamentos armazenados nas residências dos pacientes. Assim, este estudo teve como objetivo descrever a presença de sinais macroscópicos de deterioração em formas farmacêuticas encontradas nos estoques caseiros de medicamentos. Trata-se de um estudo observacional descritivo que utilizou dados de uma entrevista realizada entre agosto de 2014 e julho de 2016 nas residências de 423 usuários atendidos na atenção primária à saúde (APS) em um município mineiro de médio porte. A avaliação da deterioração foi realizada por dois pesquisadores previamente treinados que seguiram parâmetros estabelecidos na literatura. A descrição dos resultados foi feita por meio de frequência absoluta e relativa. 21 (5%) das 423 residências visitadas apresentaram pelo menos um medicamento com sinal macroscópico de deterioração. Encontrou-se uma frequência de 7,5% (n=24) de medicamentos deteriorados, sendo esta deterioração presente tanto em medicamentos que se encontravam dentro 3,2% (n=7) quanto fora do prazo de validade 4,8% (n=4). Dos outros 13 medicamentos que estavam deteriorados, não foi possível constatar a data de validade. O estudo evidenciou uma baixa frequência de deterioração macroscópica nos medicamentos encontrados nos estoques caseiros dos pacientes. Destaca-se que a deterioração não ocorreu apenas em medicamentos vencidos, fato que pode ser explicado pelas más condições de armazenamento nos domicílios.