Ryo Hamanaka
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Previous Organizations / Institutes
The organizations / institutes from the scholar's other articles in the past ten years
Research Subjects
Ryo Hamanaka has a total of 34 co-authors. Here are the top co-authors by number of shared publications:
- Noriaki Yoshida
Department of Orthodontics and Dentofacial Orthopedics, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan
7 shared publications Hiroya Komaki
Department of Orthodontic and Dentofacial Orthopedics, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
3 shared publicationsJun-Ya Tominaga
Department of Orthodontic and Dentofacial Orthopedics, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
3 shared publications- Jun-Ya Tominaga
Department of Orthodontics and Dentofacial Orthopedics, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan
3 shared publications - Toshiro Emori
Department of Orthodontics, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan
3 shared publications - Yui Horiguchi
Department of Orthodontics and Dentofacial Orthopedics, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan
3 shared publications
Latest Publications
- Open Access
- 10 July 2026
- Published by MDPI AG in Journal of Clinical Medicine
- Vol. 15 (14) , 5404
Convolutional Neural Network-Based Age Prediction from Cephalometric Images and Analysis of Site-Specific Associations
Background/Objectives: Accurate prediction of craniofacial growth is essential for establishing orthodontic diagnoses and planning treatment. However, the ultimate extent of jaw growth remains largely judged subjectively based on clinical experience. In this study, we developed a convolutional neural network (CNN) model to predict chronological age from lateral cephalograms and to investigate whether artificial intelligence (AI) can autonomously learn growth-related morphological features. We also reevaluated which anatomical regions are most informative for predicting growth. Methods: We retrospectively analyzed 2116 cephalograms from patients 5–30 years old with malocclusion. After excluding patients with craniofacial syndromes or systemic diseases, 2014 images were used for training and 102 for testing. The mean age of the training dataset was 19.51 years (standard deviation [SD]: 4.71), whereas that of the test dataset was 18.20 years (SD: 7.33). In addition to the entire cephalograms, five regional datasets were generated (mandible, maxilla, cervical vertebrae, frontal region, and cranial base). All images were resized to 256 × 256 pixels and trained with a ResNet50-based CNN. Performance was evaluated using mean absolute error (MAE), Pearson’s correlation coefficient (r), and coefficient of determination (R2). To assess growth-related learning, test data were divided into growth (5–19 years) and post-growth (20–30 years) groups, and age trends were analyzed using a sliding window approach with an 8-year window. Results: The model trained on entire cephalograms achieved high accuracy in the younger group (MAE 1.16 years, r 0.952, R2 0.884), but performance declined markedly in the older group. Among the regional models, accuracy was highest for the mandible, followed by the cervical vertebrae and maxilla. Conclusions: The CNN model predicted chronological age with high accuracy, particularly in patients <20 years old, and may have captured age-associated craniofacial features related to growth. Prediction was most accurate in the mandible and cervical vertebrae—regions clinically used to assess growth. As a proof of concept, this approach may provide a foundation for future studies of craniofacial growth prediction through transfer learning, although further validation is required.
- 10 July 2026
- Published by MDPI AG in Journal of Clinical Medicine
- Vol. 15 (14) , 5404
Open AccessConvolutional Neural Network-Based Age Prediction from Cephalometric Images and Analysis of Site-Specific Associations
Background/Objectives: Accurate prediction of craniofacial growth is essential for establishing orthodontic diagnoses and planning treatment. However, the ultimate extent of jaw growth remains largely judged subjectively based on clinical experience. In this study, we developed a convolutional neural network (CNN) model to predict chronological age from lateral cephalograms and to investigate whether artificial intelligence (AI) can autonomously learn growth-related morphological features. We also reevaluated which anatomical regions are most informative for predicting growth. Methods: We retrospectively analyzed 2116 cephalograms from patients 5–30 years old with malocclusion. After excluding patients with craniofacial syndromes or systemic diseases, 2014 images were used for training and 102 for testing. The mean age of the training dataset was 19.51 years (standard deviation [SD]: 4.71), whereas that of the test dataset was 18.20 years (SD: 7.33). In addition to the entire cephalograms, five regional datasets were generated (mandible, maxilla, cervical vertebrae, frontal region, and cranial base). All images were resized to 256 × 256 pixels and trained with a ResNet50-based CNN. Performance was evaluated using mean absolute error (MAE), Pearson’s correlation coefficient (r), and coefficient of determination (R2). To assess growth-related learning, test data were divided into growth (5–19 years) and post-growth (20–30 years) groups, and age trends were analyzed using a sliding window approach with an 8-year window. Results: The model trained on entire cephalograms achieved high accuracy in the younger group (MAE 1.16 years, r 0.952, R2 0.884), but performance declined markedly in the older group. Among the regional models, accuracy was highest for the mandible, followed by the cervical vertebrae and maxilla. Conclusions: The CNN model predicted chronological age with high accuracy, particularly in patients <20 years old, and may have captured age-associated craniofacial features related to growth. Prediction was most accurate in the mandible and cervical vertebrae—regions clinically used to assess growth. As a proof of concept, this approach may provide a foundation for future studies of craniofacial growth prediction through transfer learning, although further validation is required.
- Open Access
- 29 December 2025
- Published by Springer Nature in Progress in Orthodontics
- Vol. 26 (1) , 54
Biomechanical effect of combined use of mini-screws and aligners in preventing uncontrolled tipping of the incisor and mesial tipping of the molar: a three-dimensional finite element study
Background: This study aimed to evaluate the effect of external force applied from mini-screws to the aligner during space closure in extraction cases, and to determine the optimal loading conditions to prevent lingual crown tipping of the incisor and mesial tipping of the molar using the finite element (FE) method. Methodology: A three-dimensional FE model of the maxillary dentition with extraction of first premolars was constructed, and three different loading conditions were designed. The aligner was activated for 0.25 mm of incisor retraction without using mini-screws, with application of 0, 100, 200, or 300 cN of distal force through mini-screws placed in the posterior region, or with application of 0, 100, 200, 300, or 400 cN of intrusive force through mini-screws placed in the anterior region, in addition to the application of 300 cN of distal force. Results: As the magnitude of distal force increased, the degree of mesial tipping of the first molar gradually decreased, becoming almost zero with nearly 300 cN of distal force. As the magnitude of intrusive force increased in addition to the application of 300 cN of distal force, the degree of lingual crown tipping of the central incisor gradually decreased, becoming almost zero with nearly 400 cN of intrusive force. Conclusion: Application of 300 cN of distal force to the aligner from mini-screws placed in the posterior region could completely prevent mesial tipping of the molar and anchorage loss during anterior retraction. Application of 400 cN of intrusive force from mini-screws placed in the anterior region could prevent lingual crown tipping of the incisor, thus providing better torque control for the incisors.
- 29 December 2025
- Published by Springer Nature in Progress in Orthodontics
- Vol. 26 (1) , 54
Open AccessBiomechanical effect of combined use of mini-screws and aligners in preventing uncontrolled tipping of the incisor and mesial tipping of the molar: a three-dimensional finite element study
Background: This study aimed to evaluate the effect of external force applied from mini-screws to the aligner during space closure in extraction cases, and to determine the optimal loading conditions to prevent lingual crown tipping of the incisor and mesial tipping of the molar using the finite element (FE) method. Methodology: A three-dimensional FE model of the maxillary dentition with extraction of first premolars was constructed, and three different loading conditions were designed. The aligner was activated for 0.25 mm of incisor retraction without using mini-screws, with application of 0, 100, 200, or 300 cN of distal force through mini-screws placed in the posterior region, or with application of 0, 100, 200, 300, or 400 cN of intrusive force through mini-screws placed in the anterior region, in addition to the application of 300 cN of distal force. Results: As the magnitude of distal force increased, the degree of mesial tipping of the first molar gradually decreased, becoming almost zero with nearly 300 cN of distal force. As the magnitude of intrusive force increased in addition to the application of 300 cN of distal force, the degree of lingual crown tipping of the central incisor gradually decreased, becoming almost zero with nearly 400 cN of intrusive force. Conclusion: Application of 300 cN of distal force to the aligner from mini-screws placed in the posterior region could completely prevent mesial tipping of the molar and anchorage loss during anterior retraction. Application of 400 cN of intrusive force from mini-screws placed in the anterior region could prevent lingual crown tipping of the incisor, thus providing better torque control for the incisors.
- Open Access
- 24 December 2023
- Published by MDPI AG in Applied Sciences
- Vol. 14 (1) , 177
The Impact of Drilling Guide Length of a Surgical Guide on Accuracy of Pre-Drilling for Miniscrew Insertion
Background: Temporary anchorage devices (TADs) are broadly used in orthodontic treatment. TADs must be placed accurately to avoid collision against tooth roots. To place miniscrews with a higher accuracy, a digitally designed surgical guide was proposed in previous studies. However, to our knowledge, there have been no articles that have assessed the minimal required length to achieve good drilling accuracy. The objective of the present study was to evaluate the accuracy of pre-drilling using computer-aided designed surgical guides with different lengths. Methods: A typodont model was scanned, and surgical guides of 3.0, 4.5, and 6.0 mm were designed. Duplicated typodonts and the surgical guides were printed with a 3D printer. Using these models and surgical guides, pre-drillings were performed. Freehand drilling was also conducted for the control. The drilled models were scanned with micro-computed tomography to evaluate the accuracy. Results: The mean errors at the tip of the drill were 0.44 mm, 0.61 mm, 0.41 mm, and 0.24 mm for the freehand drilling, and 3.0, 4.5, and 6.0 mm for the surgical guide, respectively. Conclusion: The results suggested that a longer surgical guide was recommended to achieve good insertion accuracy for a narrow interradicular space, and that 3.0 mm was enough when an error of 1.0 mm was acceptable for the insertion site.
- 24 December 2023
- Published by MDPI AG in Applied Sciences
- Vol. 14 (1) , 177
Open AccessThe Impact of Drilling Guide Length of a Surgical Guide on Accuracy of Pre-Drilling for Miniscrew Insertion
Background: Temporary anchorage devices (TADs) are broadly used in orthodontic treatment. TADs must be placed accurately to avoid collision against tooth roots. To place miniscrews with a higher accuracy, a digitally designed surgical guide was proposed in previous studies. However, to our knowledge, there have been no articles that have assessed the minimal required length to achieve good drilling accuracy. The objective of the present study was to evaluate the accuracy of pre-drilling using computer-aided designed surgical guides with different lengths. Methods: A typodont model was scanned, and surgical guides of 3.0, 4.5, and 6.0 mm were designed. Duplicated typodonts and the surgical guides were printed with a 3D printer. Using these models and surgical guides, pre-drillings were performed. Freehand drilling was also conducted for the control. The drilled models were scanned with micro-computed tomography to evaluate the accuracy. Results: The mean errors at the tip of the drill were 0.44 mm, 0.61 mm, 0.41 mm, and 0.24 mm for the freehand drilling, and 3.0, 4.5, and 6.0 mm for the surgical guide, respectively. Conclusion: The results suggested that a longer surgical guide was recommended to achieve good insertion accuracy for a narrow interradicular space, and that 3.0 mm was enough when an error of 1.0 mm was acceptable for the insertion site.
- Open Access
- 14 October 2022
- Published by MDPI AG in Applied Sciences
- Vol. 12 (20) , 10346
An Efficient Distalization Technique Using Coil Springs and Mini Screws—A Finite Element Analysis
Background: More efficient molar distalization is demanded in orthodontics to shorten treatment times. In the present study, we propose a novel technique to improve force distribution to distalize molars more efficiently by using open-coil springs and an anchor screw. We conducted a finite element analysis to assess the efficiency of the proposed technique. Methods: A three-dimensional finite element model of an upper dental arch with brackets and an archwire was constructed based on cone-beam computed tomography. We analyzed two distalization methods: a conventional grouped distalization technique (NoSp model), and our proposed technique using open coils (Sp model). Finite element analyses were performed to evaluate long-term tooth movement in both techniques. Results: The distalization force was more evenly distributed in the Sp model than in the NoSp model. Moreover, less concentration of compressive stress in the periodontal ligament (PDL) was observed in the Sp model. The force systems of the two models became more similar as the distalization progressed. However, the NoSp model still showed higher stress concentration at the end of the simulation. Conclusions: Inserting open-coil springs between distalized teeth improved the distribution of the force significantly. The conventional grouped distalization method might cause stress concentration at the first premolar, indicating risks of the hyalinization of the PDL and root resorption.
- 14 October 2022
- Published by MDPI AG in Applied Sciences
- Vol. 12 (20) , 10346
Open AccessAn Efficient Distalization Technique Using Coil Springs and Mini Screws—A Finite Element Analysis
Background: More efficient molar distalization is demanded in orthodontics to shorten treatment times. In the present study, we propose a novel technique to improve force distribution to distalize molars more efficiently by using open-coil springs and an anchor screw. We conducted a finite element analysis to assess the efficiency of the proposed technique. Methods: A three-dimensional finite element model of an upper dental arch with brackets and an archwire was constructed based on cone-beam computed tomography. We analyzed two distalization methods: a conventional grouped distalization technique (NoSp model), and our proposed technique using open coils (Sp model). Finite element analyses were performed to evaluate long-term tooth movement in both techniques. Results: The distalization force was more evenly distributed in the Sp model than in the NoSp model. Moreover, less concentration of compressive stress in the periodontal ligament (PDL) was observed in the Sp model. The force systems of the two models became more similar as the distalization progressed. However, the NoSp model still showed higher stress concentration at the end of the simulation. Conclusions: Inserting open-coil springs between distalized teeth improved the distribution of the force significantly. The conventional grouped distalization method might cause stress concentration at the first premolar, indicating risks of the hyalinization of the PDL and root resorption.
- Open Access
- 31 August 2022
- Published by MDPI AG in Applied Sciences
- Vol. 12 (17) , 8742
Premolar and Molar Inclination Changes Following Micro-Implant-Assisted Maxillary Skeletal Expander (MSE): A Three-Dimensional Analysis and Visualization
Background: To assess the changes in the inclination of the premolar and molar during a maxillary expansion with a micro-implant-assisted skeletal expander (MSE). Materials and Methods: A total of 21 patients (16 females, 5 males) with a mean age of 18.6 ± 4.5 (range 11.3–26.3 years) with a transverse maxillary deficiency were included in this study. They all received an MSE appliance for the maxillary skeletal expansion. The activation protocol consisted of about 0.5 mm expansion a day until a diastema was observed and continued with about 0.25 mm a day until the desired transverse relationship between the maxilla and mandible was achieved. OnDemand3D software was used for the measurements of the inclination change in the maxillary premolars and molars, pre- and post-expansion. Graphpad was used to compare the mean change in each tooth with the zero value (no change), and the p values of these changes with every tooth were calculated. Moreover, the changes and the mean values of all the teeth on the left and right sides were calculated separately. Results: A total of sixteen measurements were conducted for each patient. The first premolars tipped palatally after the expansion, while the second premolars and molars tipped buccally. The changes were significant for the molars and the left second premolar. Conclusions: The MSE induced some changes in the tooth inclination. The first premolars moved palatally, most likely due to perioral musculature and mastication force, while the first and second molars moved buccally. The second molar buccal movement is most likely due to the craniofacial rotation caused by the MSE as they were not subject to the expansion force.
- 31 August 2022
- Published by MDPI AG in Applied Sciences
- Vol. 12 (17) , 8742
Open AccessPremolar and Molar Inclination Changes Following Micro-Implant-Assisted Maxillary Skeletal Expander (MSE): A Three-Dimensional Analysis and Visualization
Background: To assess the changes in the inclination of the premolar and molar during a maxillary expansion with a micro-implant-assisted skeletal expander (MSE). Materials and Methods: A total of 21 patients (16 females, 5 males) with a mean age of 18.6 ± 4.5 (range 11.3–26.3 years) with a transverse maxillary deficiency were included in this study. They all received an MSE appliance for the maxillary skeletal expansion. The activation protocol consisted of about 0.5 mm expansion a day until a diastema was observed and continued with about 0.25 mm a day until the desired transverse relationship between the maxilla and mandible was achieved. OnDemand3D software was used for the measurements of the inclination change in the maxillary premolars and molars, pre- and post-expansion. Graphpad was used to compare the mean change in each tooth with the zero value (no change), and the p values of these changes with every tooth were calculated. Moreover, the changes and the mean values of all the teeth on the left and right sides were calculated separately. Results: A total of sixteen measurements were conducted for each patient. The first premolars tipped palatally after the expansion, while the second premolars and molars tipped buccally. The changes were significant for the molars and the left second premolar. Conclusions: The MSE induced some changes in the tooth inclination. The first premolars moved palatally, most likely due to perioral musculature and mastication force, while the first and second molars moved buccally. The second molar buccal movement is most likely due to the craniofacial rotation caused by the MSE as they were not subject to the expansion force.
- 1 August 2021
- Published by Elsevier in American Journal of Orthodontics and Dentofacial Orthopedics
- Vol. 160 (2) , 240-249
Simulation of orthodontic tooth movement during activation of an innovative design of closing loop using the finite element method
- 1 August 2021
- Published by Elsevier in American Journal of Orthodontics and Dentofacial Orthopedics
- Vol. 160 (2) , 240-249
Simulation of orthodontic tooth movement during activation of an innovative design of closing loop using the finite element method
- 12 December 2016
- Published by Institute of Electrical and Electronics Engineers (IEEE)
- p. 1599-1603
Study on the fuel consumption in the Antarctica Showa Base microgrid
Currently, fuel consumption in the Antarctica Showa Base has been increasing along with research, observation activities and comfort of the base. Considering the limited capacity of the ship Shirase in charge of transporting fuel to the base, there is a need to ensure a sustainable provision of energy to the base by introducing renewable energy. In this study, aiming at the reduction of fuel consumption, considered the operation of the microgrid to introduce a decentralized installation of the engine generator, renewable energy, seawater source heat pump, electric thermal storage heater and a seasonal energy shift using the organic hydride to the base. As a result of the analysis, by introducing a Seasonal energy shift using an organic hydride, it was confirmed that the improved effect of reducing winter fuel consumption.
- 12 December 2016
- Published by Institute of Electrical and Electronics Engineers (IEEE)
- p. 1599-1603
Study on the fuel consumption in the Antarctica Showa Base microgrid
Currently, fuel consumption in the Antarctica Showa Base has been increasing along with research, observation activities and comfort of the base. Considering the limited capacity of the ship Shirase in charge of transporting fuel to the base, there is a need to ensure a sustainable provision of energy to the base by introducing renewable energy. In this study, aiming at the reduction of fuel consumption, considered the operation of the microgrid to introduce a decentralized installation of the engine generator, renewable energy, seawater source heat pump, electric thermal storage heater and a seasonal energy shift using the organic hydride to the base. As a result of the analysis, by introducing a Seasonal energy shift using an organic hydride, it was confirmed that the improved effect of reducing winter fuel consumption.