Ali Kürşat Tuna

Akut Eritroid Lösemi (AEL), akut miyeloid löseminin oldukça nadir görülen ve kötü prognozla seyreden bir alt tipidir. Hastalık sıklıkla kompleks karyotip ve TP53 geninde biallelik bozukluklarla ilişkilidir. Bu bölümde pansitopeni ile başvuran 62 yaşındaki erkek bir AEL olgusu sunulmuştur. Hastanın periferik yayma, kemik iliği aspirasyonu, immünohistokimyasal inceleme, akış sitometrisi ve moleküler genetik analizleri AEL tanısını desteklemiştir. Kemik iliğinde belirgin eritroid infiltrasyon saptanmış; CD71, E-kadherin ve CD117 pozitifliği ile birlikte TP53 biallelik mutasyonu ve kompleks karyotip gösterilmiştir. İleri yaş ve komorbiditeler nedeniyle azasitidin-venetoklaks tedavisi uygulanmış ancak hastalık tedaviye refrakter seyretmiş, enfeksiyöz komplikasyonlar ve septik şok gelişimi sonrası hasta tanıdan 74 gün sonra kaybedilmiştir. Bu olgu, AEL'nin agresif klinik seyir gösteren, tanısında morfolojik, immünfenotipik ve moleküler yöntemlerin birlikte değerlendirilmesini gerektiren bir hastalık olduğunu vurgulamaktadır. Ayrıca TP53 mutasyonu ve kompleks karyotip varlığının prognostik önemini ortaya koymaktadır.

Serum Periostin Levels in Newly Diagnosed Multiple Myeloma: Preliminary Observations and Treatment-related Changes - Acta Haematologica Oncologica Turcica

Background/Aims: Polycythemia vera (PV) and essential thrombocythemia (ET) are chronic myeloproliferative diseases. Along with the increase in myeloproliferative cell lines, they can cause various clinical outcomes such as arterial and venous thrombosis, pulmonary hypertension, and myocardial infarction. This study was designed to evaluate the cardiac effects of these diseases via electrocardiography and echocardiography. Methods: A total of 50 patients with a diagnosis of PV, 50 patients with a diagnosis of ET, and 50 healthy individuals as a control group were included in this study. Data on patient demographics were recorded in all subjects. All patients and control subjects had electrocardiography (ECG) recordings and routine transthoracic echocardiographic examination. Pulse wave velocity (PWV) was assessed with a Holter blood pressure device. Results: In total, 50 PV patients, 50 ET patients, and 50 control group were included in the study. The demographic characteristics of the PV, ET and control groups were similar. The PR interval was significantly shorter in control subjects than in PV and ET patients (p:0.007, p:0.024). Although the measured values were within normal limits, diastolic posterior wall thickness was significantly lower in the control group compared to PV and ET patients (p:0.019, p:0.009). PWV was significantly higher in ET patients compared to the control group (p:0.012). Conclusion: In this study, evaluating the effects of PV and ET on electrocardiography and transthoracic echocardiography; ECG parameters used to predict ventricular arrhythmias (QT, QTc, Tp-Te, Tp-Te/QT) and Pulmonary Artery Pressure showed no significant change, in opposition to existing literature. Nonetheless, similar to previous publications, PV and ET were found to negatively affect the diastolic function parameters on transthoracic echocardiography. While the aortic stiffness was significantly higher in ET patients compared to the control group, no significant difference was noted between PV patients and control subjects in terms of aortic stiffness.

Background/Aims: An impaired immune response affects Coronavirus 2019 (COVID-19) disease progression. Immunities of both hemodialysis (HD) and Kidney Transplant (KTx) patients have already been suppressed. This study evaluated the prognostic laboratory results in HD and KTx patients with COVID-19. Methods: This retrospective, case-control study was conducted with PCR (+) COVID-19 HD and KTx patients and a control group. All patients were divided into two subgroups according to disease severity. Patients' demographic records and laboratory results were obtained from the follow-up files. Results: A total of 30 HD, 20 KTx patients, and 40 control groups were involved in the study. Gender and hospitalization duration did not differ between the groups. There was a 10% mortality rate in the KTx group and 27% in the HD group. Lung involvement in Computed Tomography (CT) was higher in HD patients (47%) than in KTx (25%). In subgroup evaluations, the most prominent laboratory values were fibrinogen in HD patients and LDH and Ferritin in KTx patients in determining disease severity. Conclusions: Early hospitalization and treatment implementations will be associated with a good prognosis in HD and KTx patients since CT and laboratory results are not predictive in these groups of patients during the COVID-19 pandemic.

Objectives: We measured the serum periostin levels in patients with DLBCL and determined whether the levels reflected the clinical findings. Methods: This was a case-control study. DLBCL patients diagnosed between March 2021 and October 2021 (n=36) and healthy volunteers (n=36) (Control group) were included. The serum periostin levels of the two groups were compared. Moreover, subgroup analyses were conducted in the patient group. Results: The serum periostin level was significantly higher in the patient than the control group (28.8 ± 3.2 vs. 15.1 ± 7.5 ng/mL, p=0.017). On subgroup analyses, the median serum periostin level of nine (25%) patients with bone marrow involvement was higher than that of the 27 (75%) lacking bone marrow involvement (12.7 vs. 21.7 ng/mL, p=0.018). On ROC analysis, the optimal periostin cutoff for bone marrow involvement was 17.3 ng/mL (sensitivity 77%, specificity 67%, AUC 0.765; 95% CI; 0.606–0.924, p=0.018). By the disease stage, the periostin level was higher in stage 4 patients than in those of other stages (21.3 vs. 12.0 ng/mL, p=0.029). Conclusions: The periostin level correlated with such involvement; periostin may serve as a novel prognostic marker of DLBCL.