Austin J. Piontkowski

Journal of Medical Internet Research - International Scientific Journal for Medical Research, Information and Communication on the Internet #Preprint #PeerReviewMe: Warning: This is a unreviewed preprint. Readers are warned that the document has not been peer-reviewed by expert/patient reviewers or an academic editor, may contain misleading claims, and is likely to undergo changes before final publication, if accepted, or may have been rejected/withdrawn. Readers with interest and expertise are encouraged to sign up as peer-reviewer, if the paper is within an open peer-review period. Please cite this preprint only for review purposes or for grant applications and CVs (if you are the author). With the advent of immune checkpoint inhibitors (ICIs) for cancer treatment, patients use online forums to share experiences. As many as 60% of patients taking ICIs will develop cutaneous immune-related adverse events, which can be a good prognostic indicator for ICI treatment response. This paper explores patient sentiments in online reviews on drugs.com to ICIs, pembrolizumab and nivolumab, using Python with Selenium and manual review. There were statistically significant higher mean overall patient ratings in reviews mentioning dermatologic symptoms (DS) compared to those that did not (mean of 5.7/10 vs. 4.0/10, P=.007), and a trend towards higher sentiment scores as well (P=.074). Finally, DS-containing reviews more frequently reported positive cancer outcomes (P<.001).

Journal of Medical Internet Research - International Scientific Journal for Medical Research, Information and Communication on the Internet #Preprint #PeerReviewMe: Warning: This is a unreviewed preprint. Readers are warned that the document has not been peer-reviewed by expert/patient reviewers or an academic editor, may contain misleading claims, and is likely to undergo changes before final publication, if accepted, or may have been rejected/withdrawn. Readers with interest and expertise are encouraged to sign up as peer-reviewer, if the paper is within an open peer-review period. Please cite this preprint only for review purposes or for grant applications and CVs (if you are the author). With the advent of immune checkpoint inhibitors (ICIs) for cancer treatment, patients use online forums to share experiences. As many as 60% of patients taking ICIs will develop cutaneous immune-related adverse events, which can be a good prognostic indicator for ICI treatment response. This paper explores patient sentiments in online reviews on drugs.com to ICIs, pembrolizumab and nivolumab, using Python with Selenium and manual review. There were statistically significant higher mean overall patient ratings in reviews mentioning dermatologic symptoms (DS) compared to those that did not (mean of 5.7/10 vs. 4.0/10, P=.007), and a trend towards higher sentiment scores as well (P=.074). Finally, DS-containing reviews more frequently reported positive cancer outcomes (P<.001).

Yeast volatiles double starvation survival in Drosophila .