Celal Tuğrul Zeyrek

A Schiff base ligand (H ₂ L) was synthesized through the condensation of 3,5‐dibromo‐2‐hydroxybenzaldehyde with 1,2‐phenylenediamine and subsequently complexed with Cu(II), Ni(II), Pt(II), Fe(II), and Pd(II) ions. Synthesized compounds were examined using FT‐IR, UV–Vis, NMR, mass, elemental analysis, molar conductivity, and magnetic susceptibility. The H ₂ L and transition metal complexes were tested for their cytotoxic activity potential against human liver carcinoma (HepG2) and lung adenocarcinoma (A549) cell lines. The cytotoxic activities of compounds were determined based on their IC ₅₀ values. The Pt(II) complex exhibited high cytotoxic activity against both HepG2 and A549 cell lines; the IC ₅₀ values were obtained as 13.32 and 12.26 µM, respectively. In contrast, the Ni(II) and Fe(II) complexes displayed relatively weaker cytotoxic effects. The geometry of the PtL complex was optimized through density functional theory (DFT) calculations. Molecular docking studies were conducted to elucidate the noncovalent interactions between the optimized PtL complex and the active sites of protein BCL‐2 (PDB ID: 6QGK), selected as a putative molecular target relevant to HepG2 cells, using the DFT optimized geometry of PtL.

As of now, Türkiye has not commissioned any nuclear reactors to produce electricity; however, a major project is being completed with the Russian Federation under a Build-Own-Operate (BOO) model and is expected to begin operations towards the end of 2026. The Akkuyu Nuclear Power Plant (NPP) represents not only a milestone in diversifying Türkiye’s energy portfolio and transferring nuclear technology knowledge, but also introduces the country to the complex challenge of managing radioactive waste for the first time. This study provides an overview of Türkiye’s nuclear energy policy, the implementation and licensing process of the Akkuyu NPP, and the historical development and current status of radioactive waste management practices. Relevant legislation, particularly concerning low-level radioactive waste generated by radiation facilities, is examined to contextualize the regulatory framework. The analysis highlights the uncertainties, advantages, and disadvantages of the BOO model in relation to radioactive waste management, with special emphasis on legal mechanisms established under Turkish law. Recommendations are offered to mitigate uncertainties, strengthen regulatory clarity, and ensure that Türkiye’s nuclear energy policy adequately prepares for the safe and sustainable management of radioactive waste in the Akkuyu NPP and beyond.

An electrochemical sensor based on a SnO ₂ /Co ₃ O ₄ -modified carbon paste electrode (CPE) was developed for the quantitative determination of gilteritinib (GIL), a drug used in the treatment of acute myeloid leukemia. The SnO ₂ /Co ₃ O ₄ nanocomposite was synthesized via a precipitation–calcination route and characterized by XRD, FTIR, FE-SEM, and STEM analyses. The electrochemical properties of the modified electrode were investigated using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). Compared with bare CPE, the SnO ₂ /Co ₃ O ₄ /CPE exhibited enhanced electrocatalytic activity and faster electron-transfer kinetics, evidenced by lower peak separation (Δ E _p = 0.19 V), higher peak current ( I _p = 35 µ A), and reduced charge-transfer resistance ( R _ct = 2590 Ω). Quantitative determination of GIL was carried out using differential pulse voltammetry (DPV), yielding a wide linear range of 0.00031–11.640 μ M with limits of detection and quantification of 0.093 and 0.309 nM, respectively. The sensor showed excellent repeatability (RSD = 1.1%), reproducibility (RSD = 0.5%), high sensitivity (13.17 µ A µ M ⁻¹ cm ⁻² ), and good selectivity, with recoveries between 96.9% and 103.5%. Greenness assessment using AGREE, GAPI, and BAGI confirmed the environmentally friendly nature of the method. Overall, the proposed platform provides a sensitive and reliable approach for GIL determination with potential application in therapeutic monitoring.

Compound 4 , a Schiff base‐containing pyrimidine moiety, was synthesized from the reaction of N‐amino pyrimidine derivative with 4‐fluorobenzaldehyde. The molecular and crystallographic structure of 4 was determined by the SC‐XRD method. According to these results, compound 4 crystallized in the triclinic P‐1 space group, and the stability of its crystal structure was ensured through intermolecular C−H⋅⋅⋅π and π⋅⋅⋅π interactions. In addition to the antibacterial effects of the molecule on some Gram‐positive and Gram‐negative bacteria, the inhibition of biofilm formation in P. aeruginosa PAO1 and the production of violacein pigment in Chromobacterium violaceum ( C. violaceum) 12472 were studied. The results demonstrated that compound 4 had strong effectiveness in preventing the formation of biofilms produced by PAO1 with an inhibition rate of 69 %. Extensive theoretical calculation studies of molecule have been conducted and the molecular structure of 4 has been optimized in the ground state using density functional theory (DFT). The investigated compound's frontier molecular orbitals, chemical parameters, and molecular electrostatic potential surfaces were examined. Molecular docking studies were performed to explain the binding interaction 4 with the high inhibitory effect against C. violaceum phenylalanine hydroxylase D139A (PDB ID: 4Q3Y), D139E (PDB ID: 4Q3W), D139K (PDB ID: 4Q3Z), and D139N (PDB ID: 4Q3X) mutations.