Jiang Deng
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Previous Organizations / Institutes
The organizations / institutes from the scholar's other articles in the past ten years
Research Subjects
Research Interests
Jiang Deng has a total of 42 co-authors. Here are the top co-authors by number of shared publications:
- Lv-Hui Sun
Inner Mongolia Academy of Agriculture and Animal Husbandry Science, Hohhot, China
5 shared publications Ling Zhao
State Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Frontiers Science Center for Animal Breeding and Sustainable Production, College of Animal Sciences and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, China
3 shared publicationsGuan-Lin Wang
Selko Feed Additives, Nutreco, Stationsstraat 77, 3811, MH, Amersfoort, the Netherlands
2 shared publicationsGuoxin Gong
State Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Frontiers Science Center for Animal Breeding and Sustainable Production, College of Animal Sciences and Technology, Huazhong Agricultural University, Wuhan, Hubei 430070, China
2 shared publicationsJie Wang
State Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Frontiers Science Center for Animal Breeding and Sustainable Production, College of Animal Sciences and Technology, Huazhong Agricultural University, Wuhan, Hubei, 430070, China
2 shared publicationsMeng-Ling Ruan
State Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Frontiers Science Center for Animal Breeding and Sustainable Production, College of Animal Sciences and Technology, Huazhong Agricultural University, Wuhan, Hubei, 430070, China
2 shared publications
Latest Publications
- Open Access
- 8 May 2025
- Published by Elsevier in Poultry Science
- Vol. 104 (7) , 105149
Corrigendum to “Butyric acid-based products, alone or in combination with hydroxy-selenomethionine, improve performance of laying hens in post-peak period by modulating their antioxidant, metabolic and immune status” [Poultry Science Volume 104, Issue 4, April 2025, 104840]
- 8 May 2025
- Published by Elsevier in Poultry Science
- Vol. 104 (7) , 105149
Open AccessCorrigendum to “Butyric acid-based products, alone or in combination with hydroxy-selenomethionine, improve performance of laying hens in post-peak period by modulating their antioxidant, metabolic and immune status” [Poultry Science Volume 104, Issue 4, April 2025, 104840]
- Open Access
- 22 January 2025
- Published by Elsevier in Poultry Science
- Vol. 104 (4) , 104840
Butyric acid-based products, alone or in combination with hydroxy-selenomethionine, improve performance of laying hens in post-peak period by modulating their antioxidant, metabolic and immune status
- 22 January 2025
- Published by Elsevier in Poultry Science
- Vol. 104 (4) , 104840
Open AccessButyric acid-based products, alone or in combination with hydroxy-selenomethionine, improve performance of laying hens in post-peak period by modulating their antioxidant, metabolic and immune status
- Open Access
Remediation Strategies for Mycotoxins in Animal Feed
Mycotoxins occur widely in various animal feedstuffs, with more than 500 mycotoxins identified so far
Open AccessRemediation Strategies for Mycotoxins in Animal Feed
Mycotoxins occur widely in various animal feedstuffs, with more than 500 mycotoxins identified so far
- 19 June 2023
- Published by Elsevier in Food and Chemical Toxicology
- Vol. 178, 113907
Mitigating the adverse effects of Aflatoxin B1 in LMH, IPEC-J2 and 3D4/21 cells by a novel integrated agent
- 19 June 2023
- Published by Elsevier in Food and Chemical Toxicology
- Vol. 178, 113907
Mitigating the adverse effects of Aflatoxin B1 in LMH, IPEC-J2 and 3D4/21 cells by a novel integrated agent
- 20 February 2023
- Published by Elsevier in Food and Chemical Toxicology
- Vol. 174, 113682
Alpha-class glutathione S-transferases involved in the detoxification of aflatoxin B1 in ducklings
- 20 February 2023
- Published by Elsevier in Food and Chemical Toxicology
- Vol. 174, 113682
Alpha-class glutathione S-transferases involved in the detoxification of aflatoxin B1 in ducklings
- Open Access
- 30 May 2021
- Published by MDPI AG in Antioxidants
- Vol. 10 (6) , 878
Mitigation of Aflatoxin B1 Hepatoxicity by Dietary Hedyotis diffusa Is Associated with Activation of NRF2/ARE Signaling in Chicks
The objective of this study was to explore the mechanism of Hedyotis diffusa (HD) in mediating the detoxification of aflatoxin B1 (AFB1)-induced hepatic injury in chicks. A total of 144 one-day-old male broilers (Cobb 500) were randomly assigned to four treatment groups (n = 6 cages/diet, 6 chicks/cage). After three days of acclimation, the broilers were fed either a control diet (Control), Control plus 0.5 mg/kg of AFB1, or Control plus 0.5 mg/kg AFB1 with 500 or 1000 mg/kg HD for two weeks. Both serum and liver were collected at the end of the feeding trial for biochemistry, histology, and NF-E2-related nuclear factor 2 (NRF2)/antioxidant response element (ARE) signaling analysis. Compared with Control, the AFB1 treatment caused liver injury and decreased (p < 0.05) body weight gain, feed intake, feed conversion ratio, and serum albumin and total protein by 6.2–20.7%. AFB1 also induced swelling, necrosis, and severe vacuolar degeneration in chicks’ livers. Notably, HD supplementation at 500 and 1000 mg/kg mitigated (p < 0.05) the alterations induced by AFB1. HD supplementation alleviated (p < 0.05) AFB1-induced impairment in hepatic glutathione peroxidase activity, protein carbonyl, and exo-AFB1-8,9-epoxide (AFBO)–DNA concentrations by 57.7–100% and increased (p < 0.05) the activities of superoxide dismutase and catalase by 23.1–40.9% more than those of AFB1 treatment alone. Furthermore, HD supplementation at the two doses upregulated (p < 0.05) NRF2, NAD(P)H: quinone oxidoreductase-1, heme oxygenase-1, glutathione cysteine ligase catalytic subunit, and glutathione-S transferase A2 and A3 in livers relative to the AFB1 group by 0.99–3.4-fold. Overall, dietary supplementation of HD at a high dose displayed better protection effects against aflatoxicosis. In conclusion, a dietary HD supplementation at 500 and 1000 mg/kg protected broilers from AFB1-induced hepatotoxicity, potentially due to the activation of NRF2/ARE signaling in the chicks.
- 30 May 2021
- Published by MDPI AG in Antioxidants
- Vol. 10 (6) , 878
Open AccessMitigation of Aflatoxin B1 Hepatoxicity by Dietary Hedyotis diffusa Is Associated with Activation of NRF2/ARE Signaling in Chicks
The objective of this study was to explore the mechanism of Hedyotis diffusa (HD) in mediating the detoxification of aflatoxin B1 (AFB1)-induced hepatic injury in chicks. A total of 144 one-day-old male broilers (Cobb 500) were randomly assigned to four treatment groups (n = 6 cages/diet, 6 chicks/cage). After three days of acclimation, the broilers were fed either a control diet (Control), Control plus 0.5 mg/kg of AFB1, or Control plus 0.5 mg/kg AFB1 with 500 or 1000 mg/kg HD for two weeks. Both serum and liver were collected at the end of the feeding trial for biochemistry, histology, and NF-E2-related nuclear factor 2 (NRF2)/antioxidant response element (ARE) signaling analysis. Compared with Control, the AFB1 treatment caused liver injury and decreased (p < 0.05) body weight gain, feed intake, feed conversion ratio, and serum albumin and total protein by 6.2–20.7%. AFB1 also induced swelling, necrosis, and severe vacuolar degeneration in chicks’ livers. Notably, HD supplementation at 500 and 1000 mg/kg mitigated (p < 0.05) the alterations induced by AFB1. HD supplementation alleviated (p < 0.05) AFB1-induced impairment in hepatic glutathione peroxidase activity, protein carbonyl, and exo-AFB1-8,9-epoxide (AFBO)–DNA concentrations by 57.7–100% and increased (p < 0.05) the activities of superoxide dismutase and catalase by 23.1–40.9% more than those of AFB1 treatment alone. Furthermore, HD supplementation at the two doses upregulated (p < 0.05) NRF2, NAD(P)H: quinone oxidoreductase-1, heme oxygenase-1, glutathione cysteine ligase catalytic subunit, and glutathione-S transferase A2 and A3 in livers relative to the AFB1 group by 0.99–3.4-fold. Overall, dietary supplementation of HD at a high dose displayed better protection effects against aflatoxicosis. In conclusion, a dietary HD supplementation at 500 and 1000 mg/kg protected broilers from AFB1-induced hepatotoxicity, potentially due to the activation of NRF2/ARE signaling in the chicks.