Li Xue

Background/Objectives: Dietary microstructure affects energy intake. Traditional Universal Eating Monitors (UEMs) offer accuracy but are limited for monitoring diverse diets. We developed the ‘Feeding Table’, a novel UEM that simultaneously tracks intake of up to 12 foods, enabling high-resolution monitoring of eating microstructure for multiple foods simultaneously. Methods: Forty-nine healthy volunteers participated: 15 (10 male, 8 female) in a location preference experiment and 31 (15 male, 16 female) in a standard meal test. The location preference study involved four weekly sessions. Participants received a standardized breakfast based on individual energy needs; lunch intake was measured 3 h later with food items in pseudo-randomized positions. The standard meal test occurred over two consecutive days to assess the Feeding Table’s performance in monitoring eating behavior under standardized conditions. Results: In two consecutive days of standard meal tests, the Feeding Table showed reasonable day-to-day repeatability for energy and macronutrient intake (energy: r = 0.82; fat: r = 0.86; carbohydrate: r = 0.86; protein: r = 0.58). Among the four repeated intake measurements, the results demonstrated high intra-class correlation coefficients (ICCs: energy 0.94, protein 0.90, fat 0.90, and carbohydrate 0.93). No significant positional bias was observed (energy: p = 0.07; macronutrients: p = 0.70). Conclusions: The Feeding Table maintains UEM accuracy while enabling multi-food, real-time monitoring of dietary microstructure and food choice, offering enhanced precision for studying eating behaviors.

As a multifaceted adipokine, chemerin has been found to perform functions vital for immunity, adiposity, and metabolism through its three known receptors (chemokine-like receptor 1, CMKLR1; G-protein-coupled receptor 1, GPR1; C-C motif chemokine receptor-like 2, CCRL2). Chemerin and the cognate receptors are also expressed in the hypothalamus, pituitary gland, testis, ovary, and placenta. Accumulating studies suggest that chemerin participates in normal reproduction and underlies the pathological mechanisms of certain reproductive system diseases, including polycystic ovary syndrome (PCOS), preeclampsia, and breast cancer. Herein, we present a comprehensive review of the roles of the chemerin system in multiple reproductive processes and human reproductive diseases, with a brief discussion and perspectives on future clinical applications.

Depression affects the reproductive axis at the hypothalamus and pituitary levels, which has a significant impact on female fertility. It has been reported that G protein-coupled receptor 1 (Gpr1) mRNA is expressed in both the hypothalamus and ovaries. However, it is unclear whether there is a relationship between Gpr1 and depression, and its role in ovarian function is unknown. Here, the expression of Gpr1 was recorded in the hypothalamus of normal female mice, and co-localized with gonadotrophin-releasing hormone (GnRH) and corticotropin-releasing factor (CRF). We established a depression mouse model to evaluate the antidepressant effect of G5, an antagonistic peptide of Gpr1. The results show that an intraperitoneal injection of G5 improves depressant–like behaviors remarkably, including increased sucrose intake in the sucrose preference test and decreased immobility time in the forced swimming tests. Moreover, G5 treatment increased the release of reproductive hormone and the expression of ovarian gene caused by depression. Together, our findings reveal a link between depression and reproductive diseases through Gpr1 signaling, and suggest antagonistic peptide of Gpr1 as a potential therapeutic application for hormone-modulated depression in women.