Alexander J. Helmboldt
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Previous Organizations / Institutes
The organizations / institutes from the scholar's other articles in the past ten years
Research Subjects
Alexander J. Helmboldt has a total of 64 co-authors. Here are the top co-authors by number of shared publications:
- Vedran Brdar
Oklahoma State University
10 shared publications - Manfred Lindner
Max-Planck-Institut für Kernphysik, 69117 Heidelberg, Germany
6 shared publications - Daniele Barducci
SISSA and INFN Sezione di Trieste
2 shared publications - Jisuke Kubo
Max-Planck-Institut für Kernphysik Saupfercheckweg 1 69117 Heidelberg Germany
2 shared publications - Kai Schmitz
University of Munster
2 shared publications - Lukáš Gráf
Institute of Particle and Nuclear Physics, Faculty of Mathematics and Physics, Charles University in Prague
2 shared publications
Latest Publications
- Open Access
- 20 October 2022
- Published by Springer Nature in Nature Communications
- Vol. 13 (1) , 1-18
Proteogenomics refines the molecular classification of chronic lymphocytic leukemia
Cancer heterogeneity at the proteome level may explain differences in therapy response and prognosis beyond the currently established genomic and transcriptomic-based diagnostics. The relevance of proteomics for disease classifications remains to be established in clinically heterogeneous cancer entities such as chronic lymphocytic leukemia (CLL). Here, we characterize the proteome and transcriptome alongside genetic and ex-vivo drug response profiling in a clinically annotated CLL discovery cohort (n = 68). Unsupervised clustering of the proteome data reveals six subgroups. Five of these proteomic groups are associated with genetic features, while one group is only detectable at the proteome level. This new group is characterized by accelerated disease progression, high spliceosomal protein abundances associated with aberrant splicing, and low B cell receptor signaling protein abundances (ASB-CLL). Classifiers developed to identify ASB-CLL based on its characteristic proteome or splicing signature in two independent cohorts (n = 165, n = 169) confirm that ASB-CLL comprises about 20% of CLL patients. The inferior overall survival in ASB-CLL is also independent of both TP53- and IGHV mutation status. Our multi-omics analysis refines the classification of CLL and highlights the potential of proteomics to improve cancer patient stratification beyond genetic and transcriptomic profiling.
- 20 October 2022
- Published by Springer Nature in Nature Communications
- Vol. 13 (1) , 1-18
Open AccessProteogenomics refines the molecular classification of chronic lymphocytic leukemia
Cancer heterogeneity at the proteome level may explain differences in therapy response and prognosis beyond the currently established genomic and transcriptomic-based diagnostics. The relevance of proteomics for disease classifications remains to be established in clinically heterogeneous cancer entities such as chronic lymphocytic leukemia (CLL). Here, we characterize the proteome and transcriptome alongside genetic and ex-vivo drug response profiling in a clinically annotated CLL discovery cohort (n = 68). Unsupervised clustering of the proteome data reveals six subgroups. Five of these proteomic groups are associated with genetic features, while one group is only detectable at the proteome level. This new group is characterized by accelerated disease progression, high spliceosomal protein abundances associated with aberrant splicing, and low B cell receptor signaling protein abundances (ASB-CLL). Classifiers developed to identify ASB-CLL based on its characteristic proteome or splicing signature in two independent cohorts (n = 165, n = 169) confirm that ASB-CLL comprises about 20% of CLL patients. The inferior overall survival in ASB-CLL is also independent of both TP53- and IGHV mutation status. Our multi-omics analysis refines the classification of CLL and highlights the potential of proteomics to improve cancer patient stratification beyond genetic and transcriptomic profiling.
- Open Access
Strong Supercooling as a Consequence of Renormalization Group Consistency
Classically scale-invariant models are attractive not only because they may offer a solution to the long-standing gauge hierarchy problem, but also due to their role in facilitating strongly supercooled cosmic phase transitions. In this paper, we investigate the interplay between these two aspects. We do so in the context of the electroweak phase transition (EWPT) in the minimal scale-invariant theory. We find that the amount of supercooling generally decreases for increasing scalar couplings. However, the stabilization of the electroweak scale against the Planck scale requires the absence of Landau poles in the respective energy range. Scalar couplings at the TeV scale can therefore not become larger than $\mathcal{O}(10^{-1})$. As a consequence, all fully consistent parameter points predict the EWPT not to complete before the QCD transition, which then eventually triggers the generation of the electroweak scale. We also discuss the potential of the model to give rise to an observable gravitational wave signature, as well as the possibility to accommodate a dark matter candidate.Open AccessStrong Supercooling as a Consequence of Renormalization Group Consistency
Classically scale-invariant models are attractive not only because they may offer a solution to the long-standing gauge hierarchy problem, but also due to their role in facilitating strongly supercooled cosmic phase transitions. In this paper, we investigate the interplay between these two aspects. We do so in the context of the electroweak phase transition (EWPT) in the minimal scale-invariant theory. We find that the amount of supercooling generally decreases for increasing scalar couplings. However, the stabilization of the electroweak scale against the Planck scale requires the absence of Landau poles in the respective energy range. Scalar couplings at the TeV scale can therefore not become larger than $\mathcal{O}(10^{-1})$. As a consequence, all fully consistent parameter points predict the EWPT not to complete before the QCD transition, which then eventually triggers the generation of the electroweak scale. We also discuss the potential of the model to give rise to an observable gravitational wave signature, as well as the possibility to accommodate a dark matter candidate. - Open Access
- 30 December 2019
- Published by Springer Nature in Journal of High Energy Physics
- Vol. 2019 (12) , 158
Strong supercooling as a consequence of renormalization group consistency
Classically scale-invariant models are attractive not only because they may offer a solution to the long-standing gauge hierarchy problem, but also due to their role in facilitating strongly supercooled cosmic phase transitions. In this paper, we investigate the interplay between these two aspects. We do so in the context of the electroweak phase transition (EWPT) in the minimal scale-invariant theory. We find that the amount of supercooling generally decreases for increasing scalar couplings. However, the stabilization of the electroweak scale against the Planck scale requires the absence of Landau poles in the respective energy range. Scalar couplings at the TeV scale can therefore not become larger than 𝒪(10 −1). As a consequence, all fully consistent parameter points predict the EWPT not to complete before the QCD transition, which then eventually triggers the generation of the electroweak scale. We also discuss the potential of the model to give rise to an observable gravitational wave signature, as well as the possibility to accommodate a dark matter candidate.
- 30 December 2019
- Published by Springer Nature in Journal of High Energy Physics
- Vol. 2019 (12) , 158
Open AccessStrong supercooling as a consequence of renormalization group consistency
Classically scale-invariant models are attractive not only because they may offer a solution to the long-standing gauge hierarchy problem, but also due to their role in facilitating strongly supercooled cosmic phase transitions. In this paper, we investigate the interplay between these two aspects. We do so in the context of the electroweak phase transition (EWPT) in the minimal scale-invariant theory. We find that the amount of supercooling generally decreases for increasing scalar couplings. However, the stabilization of the electroweak scale against the Planck scale requires the absence of Landau poles in the respective energy range. Scalar couplings at the TeV scale can therefore not become larger than 𝒪(10 −1). As a consequence, all fully consistent parameter points predict the EWPT not to complete before the QCD transition, which then eventually triggers the generation of the electroweak scale. We also discuss the potential of the model to give rise to an observable gravitational wave signature, as well as the possibility to accommodate a dark matter candidate.
- Open Access
Gravitational Waves as a Probe of Left-Right Symmetry Breaking
Left-right symmetry at high energy scales is a well-motivated extension of the Standard Model. In this paper we consider a typical minimal scenario in which it gets spontaneously broken by scalar triplets. Such a realization has been scrutinized over the past few decades chiefly in the context of collider studies. In this work we take a complementary approach and investigate whether the model can be probed via the search for a stochastic gravitational wave background induced by the phase transition in which $SU(3)_C \times SU(2)_L \times SU(2)_R \times U(1)_{B-L}$ is broken down to the Standard Model gauge symmetry group. A prerequisite for gravitational wave production in this context is a first-order phase transition, the occurrence of which we find in a significant portion of the parameter space. Although the produced gravitational waves are typically too weak for a discovery at any current or future detector, upon investigating correlations between all relevant terms in the scalar potential, we have identified values of parameters leading to observable signals. This indicates that, given a certain moderate fine-tuning, the minimal left-right symmetric model with scalar triplets features another powerful probe which can lead to either novel constraints or remarkable discoveries in the near future. Let us note that some of our results, such as the full set of thermal masses, have to the best of our knowledge not been presented before and might be useful for future studies, in particular in the context of electroweak baryogenesis.Open AccessGravitational Waves as a Probe of Left-Right Symmetry Breaking
Left-right symmetry at high energy scales is a well-motivated extension of the Standard Model. In this paper we consider a typical minimal scenario in which it gets spontaneously broken by scalar triplets. Such a realization has been scrutinized over the past few decades chiefly in the context of collider studies. In this work we take a complementary approach and investigate whether the model can be probed via the search for a stochastic gravitational wave background induced by the phase transition in which $SU(3)_C \times SU(2)_L \times SU(2)_R \times U(1)_{B-L}$ is broken down to the Standard Model gauge symmetry group. A prerequisite for gravitational wave production in this context is a first-order phase transition, the occurrence of which we find in a significant portion of the parameter space. Although the produced gravitational waves are typically too weak for a discovery at any current or future detector, upon investigating correlations between all relevant terms in the scalar potential, we have identified values of parameters leading to observable signals. This indicates that, given a certain moderate fine-tuning, the minimal left-right symmetric model with scalar triplets features another powerful probe which can lead to either novel constraints or remarkable discoveries in the near future. Let us note that some of our results, such as the full set of thermal masses, have to the best of our knowledge not been presented before and might be useful for future studies, in particular in the context of electroweak baryogenesis. - 1 December 2019
- Published by IOP Publishing in Journal of Cosmology and Astroparticle Physics
- Vol. 2019 (12) , 027
Gravitational waves as a probe of left-right symmetry breaking
- 1 December 2019
- Published by IOP Publishing in Journal of Cosmology and Astroparticle Physics
- Vol. 2019 (12) , 027
Gravitational waves as a probe of left-right symmetry breaking
- Open Access
Type-I Seesaw as the Common Origin of Neutrino Mass, Baryon Asymmetry, and the Electroweak Scale
The type-I seesaw represents one of the most popular extensions of the Standard Model. Previous studies of this model have mostly focused on its ability to explain neutrino oscillations as well as on the generation of the baryon asymmetry via leptogenesis. Recently, it has been pointed out that the type-I seesaw can also account for the origin of the electroweak scale due to heavy-neutrino threshold corrections to the Higgs potential. In this paper, we show for the first time that all of these features of the type-I seesaw are compatible with each other. Integrating out a set of heavy Majorana neutrinos results in small masses for the Standard Model neutrinos; baryogenesis is accomplished by resonant leptogenesis; and the Higgs mass is entirely induced by heavy-neutrino one-loop diagrams, provided that the tree-level Higgs potential satisfies scale-invariant boundary conditions in the ultraviolet. The viable parameter space is characterized by a heavy-neutrino mass scale roughly in the range $10^{6.5\cdots7.0}$ GeV and a mass splitting among the nearly degenerate heavy-neutrino states up to a few TeV. Our findings have interesting implications for high-energy flavor models and low-energy neutrino observables. We conclude that the type-I seesaw sector might be the root cause behind the masses and cosmological abundances of all known particles. This statement might even extend to dark matter in the presence of a keV-scale sterile neutrino.Open AccessType-I Seesaw as the Common Origin of Neutrino Mass, Baryon Asymmetry, and the Electroweak Scale
The type-I seesaw represents one of the most popular extensions of the Standard Model. Previous studies of this model have mostly focused on its ability to explain neutrino oscillations as well as on the generation of the baryon asymmetry via leptogenesis. Recently, it has been pointed out that the type-I seesaw can also account for the origin of the electroweak scale due to heavy-neutrino threshold corrections to the Higgs potential. In this paper, we show for the first time that all of these features of the type-I seesaw are compatible with each other. Integrating out a set of heavy Majorana neutrinos results in small masses for the Standard Model neutrinos; baryogenesis is accomplished by resonant leptogenesis; and the Higgs mass is entirely induced by heavy-neutrino one-loop diagrams, provided that the tree-level Higgs potential satisfies scale-invariant boundary conditions in the ultraviolet. The viable parameter space is characterized by a heavy-neutrino mass scale roughly in the range $10^{6.5\cdots7.0}$ GeV and a mass splitting among the nearly degenerate heavy-neutrino states up to a few TeV. Our findings have interesting implications for high-energy flavor models and low-energy neutrino observables. We conclude that the type-I seesaw sector might be the root cause behind the masses and cosmological abundances of all known particles. This statement might even extend to dark matter in the presence of a keV-scale sterile neutrino. - Open Access
- 22 October 2019
- Published by American Physical Society (APS) in Physical Review D
- Vol. 100 (7) , 075029
Type I seesaw mechanism as the common origin of neutrino mass, baryon asymmetry, and the electroweak scale
The type I seesaw represents one of the most popular extensions of the Standard Model. Previous studies of this model have mostly focused on its ability to explain neutrino oscillations as well as on the generation of the baryon asymmetry via leptogenesis. Recently, it has been pointed out that the type I seesaw can also account for the origin of the electroweak scale due to heavy-neutrino threshold corrections to the Higgs potential. In this paper, we show for the first time that all of these features of the type I seesaw are compatible with each other. Integrating out a set of heavy Majorana neutrinos results in small masses for the Standard Model neutrinos; baryogenesis is accomplished by resonant leptogenesis; and the Higgs mass is entirely induced by heavy-neutrino one-loop diagrams, provided that the tree-level Higgs potential satisfies scale-invariant boundary conditions in the ultraviolet. The viable parameter space is characterized by a heavy-neutrino mass scale roughly in the range and a mass splitting among the nearly degenerate heavy-neutrino states up to a few TeV. Our findings have interesting implications for high-energy flavor models and low-energy neutrino observables. We conclude that the type I seesaw sector might be the root cause behind the masses and cosmological abundances of all known particles. This statement might even extend to dark matter in the presence of a keV-scale sterile neutrino.- 22 October 2019
- Published by American Physical Society (APS) in Physical Review D
- Vol. 100 (7) , 075029
Open AccessType I seesaw mechanism as the common origin of neutrino mass, baryon asymmetry, and the electroweak scale
The type I seesaw represents one of the most popular extensions of the Standard Model. Previous studies of this model have mostly focused on its ability to explain neutrino oscillations as well as on the generation of the baryon asymmetry via leptogenesis. Recently, it has been pointed out that the type I seesaw can also account for the origin of the electroweak scale due to heavy-neutrino threshold corrections to the Higgs potential. In this paper, we show for the first time that all of these features of the type I seesaw are compatible with each other. Integrating out a set of heavy Majorana neutrinos results in small masses for the Standard Model neutrinos; baryogenesis is accomplished by resonant leptogenesis; and the Higgs mass is entirely induced by heavy-neutrino one-loop diagrams, provided that the tree-level Higgs potential satisfies scale-invariant boundary conditions in the ultraviolet. The viable parameter space is characterized by a heavy-neutrino mass scale roughly in the range and a mass splitting among the nearly degenerate heavy-neutrino states up to a few TeV. Our findings have interesting implications for high-energy flavor models and low-energy neutrino observables. We conclude that the type I seesaw sector might be the root cause behind the masses and cosmological abundances of all known particles. This statement might even extend to dark matter in the presence of a keV-scale sterile neutrino. - Open Access
Observational prospects for gravitational waves from hidden or dark chiral phase transitions
We study the gravitational wave (GW) signature of first-order chiral phase transitions ($\chi$PT) in strongly interacting hidden or dark sectors. We do so using several effective models in order to reliably capture the relevant non-perturbative dynamics. This approach allows us to explicitly calculate key quantities characterizing the $\chi$PT without having to resort to rough estimates. Most importantly, we find that the transition's inverse duration $\beta$ normalized to the Hubble parameter $H$ is at least two orders of magnitude larger than typically assumed in comparable scenarios, namely $\beta/H\gtrsim\mathcal{O}(10^4)$. The obtained GW spectra then suggest that signals from hidden $\chi$PTs occurring at around 100 MeV can be in reach of LISA, while DECIGO and BBO may detect a stochastic GW background associated with transitions between roughly 1 GeV and 10 TeV. Signatures of transitions at higher temperatures are found to be outside the range of any currently proposed experiment. Even though predictions from different effective models are qualitatively similar, we find that they may vary considerably from a quantitative point of view, which highlights the need for true first-principle calculations such as lattice simulations.Open AccessObservational prospects for gravitational waves from hidden or dark chiral phase transitions
We study the gravitational wave (GW) signature of first-order chiral phase transitions ($\chi$PT) in strongly interacting hidden or dark sectors. We do so using several effective models in order to reliably capture the relevant non-perturbative dynamics. This approach allows us to explicitly calculate key quantities characterizing the $\chi$PT without having to resort to rough estimates. Most importantly, we find that the transition's inverse duration $\beta$ normalized to the Hubble parameter $H$ is at least two orders of magnitude larger than typically assumed in comparable scenarios, namely $\beta/H\gtrsim\mathcal{O}(10^4)$. The obtained GW spectra then suggest that signals from hidden $\chi$PTs occurring at around 100 MeV can be in reach of LISA, while DECIGO and BBO may detect a stochastic GW background associated with transitions between roughly 1 GeV and 10 TeV. Signatures of transitions at higher temperatures are found to be outside the range of any currently proposed experiment. Even though predictions from different effective models are qualitatively similar, we find that they may vary considerably from a quantitative point of view, which highlights the need for true first-principle calculations such as lattice simulations. - Open Access
- 16 September 2019
- Published by American Physical Society (APS) in Physical Review D
- Vol. 100 (5) , 055025
Observational prospects for gravitational waves from hidden or dark chiral phase transitions
We study the gravitational-wave (GW) signature of first-order chiral phase transitions () in strongly interacting hidden or dark sectors. We do so using several effective models in order to reliably capture the relevant nonperturbative dynamics. This approach allows us to explicitly calculate key quantities characterizing the without having to resort to rough estimates. Most importantly, we find that the transition’s inverse duration normalized to the Hubble parameter is at least 2 orders of magnitude larger than typically assumed in comparable scenarios, namely, . The obtained GW spectra then suggest that signals from hidden occurring at around 100 MeV might be in reach of LISA, while DECIGO and BBO may detect a stochastic GW background associated with transitions between roughly 1 GeV and 10 TeV. Signatures of transitions at higher temperatures are found to be outside the range of any currently proposed experiment. Even though predictions from different effective models are qualitatively similar, we find that they may vary considerably from a quantitative point of view, which highlights the need for true first-principle calculations such as lattice simulations.- 16 September 2019
- Published by American Physical Society (APS) in Physical Review D
- Vol. 100 (5) , 055025
Open AccessObservational prospects for gravitational waves from hidden or dark chiral phase transitions
We study the gravitational-wave (GW) signature of first-order chiral phase transitions () in strongly interacting hidden or dark sectors. We do so using several effective models in order to reliably capture the relevant nonperturbative dynamics. This approach allows us to explicitly calculate key quantities characterizing the without having to resort to rough estimates. Most importantly, we find that the transition’s inverse duration normalized to the Hubble parameter is at least 2 orders of magnitude larger than typically assumed in comparable scenarios, namely, . The obtained GW spectra then suggest that signals from hidden occurring at around 100 MeV might be in reach of LISA, while DECIGO and BBO may detect a stochastic GW background associated with transitions between roughly 1 GeV and 10 TeV. Signatures of transitions at higher temperatures are found to be outside the range of any currently proposed experiment. Even though predictions from different effective models are qualitatively similar, we find that they may vary considerably from a quantitative point of view, which highlights the need for true first-principle calculations such as lattice simulations. - Open Access
Conformal Realization of the Neutrino Option
It was recently proposed that the electroweak hierarchy problem is absent if the generation of the Higgs potential stems exclusively from quantum effects of heavy right-handed neutrinos which can also generate active neutrino masses via the type-I seesaw mechanism. Hence, in this framework dubbed the "neutrino option", the tree-level scalar potential is assumed to vanish at high energies. Such a scenario therefore lends itself particularly well to be embedded in a classically scale-invariant theory. In this paper we perform a survey of models featuring conformal symmetry at the high scale. We find that the minimal framework compatible with the "neutrino option" requires the Standard Model to be extended by two real scalar singlet fields in addition to right-handed neutrinos. The spontaneous breaking of scale invariance, which induces the dynamical generation of Majorana masses for the right-handed neutrinos, is triggered by renormalization group effects. We identify the parameter space of the model for which a phenomenologically viable Higgs potential and neutrino masses are generated, and for which all coupling constants remain in the perturbative regime up to the Planck scale.
Open AccessConformal Realization of the Neutrino Option
It was recently proposed that the electroweak hierarchy problem is absent if the generation of the Higgs potential stems exclusively from quantum effects of heavy right-handed neutrinos which can also generate active neutrino masses via the type-I seesaw mechanism. Hence, in this framework dubbed the "neutrino option", the tree-level scalar potential is assumed to vanish at high energies. Such a scenario therefore lends itself particularly well to be embedded in a classically scale-invariant theory. In this paper we perform a survey of models featuring conformal symmetry at the high scale. We find that the minimal framework compatible with the "neutrino option" requires the Standard Model to be extended by two real scalar singlet fields in addition to right-handed neutrinos. The spontaneous breaking of scale invariance, which induces the dynamical generation of Majorana masses for the right-handed neutrinos, is triggered by renormalization group effects. We identify the parameter space of the model for which a phenomenologically viable Higgs potential and neutrino masses are generated, and for which all coupling constants remain in the perturbative regime up to the Planck scale.