Mandava Venkata Basaveswara Rao

Spinel nano-ferrites offer a promising photocatalytic approach for environmental remediation. Employing a combustion method, a new spinel Mn0.5Cd0.5PrxFe2-xO4 (x = 0-5) nano-ferrite as photocatalysts have been developed for the degradation of Congo red dye. P-XRD, FTIR, HR-TEM, UV-VIS, VSM and photon-driven catalytic processes for the degradation of Congo red dye have been employed to analyze each of the Mn0.5Cd0.5PrxFe2-xO4 (x = 0-5) nano-ferrites. P-XRD analysis was used to determine the lattice strain and crystallite size of each nano-ferrite sample, revealing the crystallite sizes ranging from 23.11 to 32.84 nm. The total surface areas, densities, bond lengths and hopping lengths of each Pr-sample nanocrystal were also determined and calculated. FTIR analysis revealed two prominent frequency bands at 602 and 425 cm–1, characteristic of spinel ferrites. The particle size and distribution of the nano-ferrites in the Pr-0 to Pr-5 samples were examined using FE-SEM, which showed spherical Pr-Mn-Cd nanoparticles with a tendency to aggregate. The direct allowed bandgap (Eg) values for Pr-0 through Pr-5 were estimated from Tauc plots as 2.66, 2.45, 2.34, 2.22, 2.10 and 1.97 eV, respectively. The variation in bandgap (Eg) values can be attributed to the combined effects of doping and particle size. Magnetic measurements showed a systematic decrease in saturation magnetization (Ms), magnetocrystalline anisotropy (K1), coercivity (Hc) with Pr-substitution.

Background: The synthesis of optically active heterocycles, such as those containing the octahydroindolizine skeleton, is pivotal in organic and medicinal chemistry. This skeleton is a core structure in numerous biologically significant alkaloids, including slaframine and Castano spermine. Their pharmacological potential necessitates the development of efficient and stereoselective synthetic methodologies.Materials and Methods: This study reports a novel synthetic strategy for N-Benzyl-(8S)-4-(benzenesulfonyl)-8-hydroxyazonan-5-one, a precursor for (6S)-octahydroindolizin-6-ol. The synthesis involves multiple steps starting from the sodium salt of benzene sulfonyl chloride. Key reactions include alkylation, cyclization, and debenzylation, employing reagents such as dibromo propane, benzylamine, (S)-epichlorohydrin, and diethyl malonate. TLC monitored reaction progress, and the compounds were characterized using NMR and mass spectrometry.Results: The targeted precursor was successfully synthesized via a systematic sequence of reactions, with each intermediate confirmed through analytical and spectral data. This approach achieved high yields at critical steps, demonstrating its efficiency. The final compound, N-Benzyl-(8S)-4-(benzene sulfonyl)-8-hydroxyazonan-5-one, was synthesized with a yield of 58.1%, showcasing the method’s feasibility.Conclusion: This study presents a robust and stereoselective synthetic pathway for producing the N-Benzyl-(8S)-4-(benzenesulfonyl)-8-hydroxyazonan-5-one, a crucial intermediate for alkaloid analogs with significant pharmacological potential. The strategy highlights innovative steps in heterocycle synthesis, contributing to advancements in medicinal chemistry.

Synthetic methodology developed for (–)-(5R, 6S)-erythro-6-acetoxy-5-hexadecanolide,which is a D-ribose based synthetic pheromone used to promote mosquito oviposition. The important steps involved are Grignard reaction, oxidative cleavage of 1,2-diol followed by Wittig-Horner reaction, lactonization with magnesium and acetylation.

A very simple, more accurate, and highly precise process is refined to development of two combination drugs Dolutegravir (DUA), Rilpivirine (RPV)in the tablet dosage form. For this development Agilent 100-5C18 column (250mm x 4.6mm).Acetonitrile as 40v/v and Phosphate buffer which is maintained at pH 4.0as 60v/vis passed with the help of column. Flow rate was measure as 0.80ml/min. Column temperature is accompanied as ambient. Upgraded wavelength is 235 nm. Run time is identified as 10 minutes and the volume injected for this analysis is 20 µl. Retention time of DUA and RPV were found to be 2.6 & 3.9min. %RSD of the DUA and RPV were and found to be 0.87, 0.40 as intraday and 0.75 and 0.56 as inter day precision. % Recovery was obtained as 98.59%, 100.7% for DUA and RPV respectively. The Rt values are minimized as well as run time was decreased. Finally, concluded that this proposed and developed process is more simple as well as economical which should be prevalent in regular QC labs and present in the plasma samples.

Oriental Journal of Chemistry is a peer reviewed quarterly research journal of pure and applied chemistry. It publishes standard research papers in almost all thrust areas of current chemistry of academic and commercial importance. It provides a platform for rapid publication of quality research papers, reviews and chemistry letters. Oriental Journal of Chemistry is abstracted and indexed in almost all reputed National and International agencies.

The primary objective of this research was to delve into the forced degradation products of Rilpivirine hydrochloride (RLP HCl), a crucial non-nucleoside reverse transcriptase inhibitor employed inmanagement of epidemic disease named HIV-1. The investigation utilised the probable of RP-HPLC in tandem with peak purity assessment .In order to simulate conceivable degradation pathways, the study encompassed a gamut of stress conditions like acidic, alkaline, oxidative , thermal and photolytic environments. Authors used Agilent zorbaxEclipse XDB C18 column (150x2.1mm, 1.8µm), RLP and impurities were separated. Buffer as pH of 3.0 and acetonitrile in gradient mode (68:32v/v), flow rate of 0.55ml/min. Volume injected is 3µL and detection wavelength is 220 nm. Temperature is maintained at 55oC by 70:30v/v mixture of water and acetonitrile.System suitability was erect to be within the limits. The average percentage recoveries for impurities were 98% to 101%.The outcomes of this meticulous study unveiled the susceptibilities of RLP to a spectrum of stress factors, in the generation of impurity profile RLP-Amide A, RLP-Amide Band Z-RLP with peak purities. The forced degradation tests demonstrate that the peak of RP-HPLC is spectroscopically pure in all stressed conditions. All degradation products are separated from the main peak and do not interfere with main substance. This exploration not only augments the comprehension of RLP’s stability profile but also underscores the pivotal role of analytical techniques in upholding the safety and efficacy benchmarks of pharmaceutical formulations.

A new copper(I) catalytic system has been developed for the alkyne–azide click reaction. 3,5-Dibenzylidene-1-(prop-2-yn-1-yl)piperidin-4-ones reacted with alkyl azides in water–tert-butyl alcohol (1:1) in the presence of a mixture of CuSO₄·5H₂O and sodium ascorbate to afford 3,5-dibenzylidene-1-(1-alkyl-1H-1,2,3-triazol-4-ylmethyl)piperidin-4-ones in good yields.