Ismail Ersan

Aim To compare the efficacy of nepafenac monotherapy with the combination of nepafenac and dexamethasone for preventing pseudophakic cystoid macular edema (PCME), one of the most common complications after cataract surgery. Methods This retrospective study included patients who underwent uncomplicated cataract surgery. They were divided into two groups: Group 1 (Monotherapy) received nepafenac alone, while Group 2 (Combination Therapy) received nepafenac with dexamethasone. Postoperative central macular thickness and cystoid changes were monitored using optical coherence tomography (OCT). Statistical analyses were performed to compare the efficacy of both regimens in preventing PCME. Results Both treatment groups were effective in reducing macular thickening and lowering the risk of clinically significant PCME. However, no statistically significant difference in efficacy was found between nepafenac monotherapy and combination therapy. This finding suggests that adding dexamethasone did not confer a measurable advantage in preventing PCME compared with nepafenac alone. Conclusion Our study demonstrates that nepafenac monotherapy is as effective as combination therapy for PCME prophylaxis. The lack of additional benefit from the combination suggests that monotherapy may be a more practical approach, as it can improve patient compliance, reduce side effects, and simplify the treatment regimen. Although our study has limitations, including a small sample size and the use of a single NSAID, our findings contribute to the literature supporting NSAID monotherapy in postoperative cataract management. Larger, randomized controlled trials are needed to confirm these results.

ÖZET Amaç: Spektral domain optik koherens tomografi (SD-OKT) ile ölçülen peripapiller retina sinir lifi tabakası (RSLT), ganglion hücre kompleksi (GHK) ve optik sinir başı (OSB) parametreleri ile görme alanı (GA) parametrelerini kullanarak glokom tanısı koymak için derin öğrenme modeli geliştirmeyi amaçladık. Yöntemler: Glokom tanılı 78 hasta ile 53 sağlıklı olgu çalışmaya dahil edildi. Veri kümesi %60 eğitim %40 test şeklinde ayrıldı. Derin öğrenme modeli geliştirmek için RSLT, GHK, optik sini başı parametreleri ile görme alanı parametreleri kullanıldı. İlgili model RapidMinerStudio9.2 sürümü üzerinde gerçekleştirilmiştir. Bulgular: Geliştirilen derin öğrenme modelimiz test grubunda AUC değeri 0,817 ve duyarlılığı % 96 bulundu. Sonuç: SD-OKT ve görme alanı parametrelerini kullandığımız derin öğrenme modelimiz glokomatöz değişikliklerin saptanmasında yüksek duyarlılık ve özgüllüğe sahip bulundu. Anahtar Kelimeler: Glokom, derin öğrenme, optik koherens tomografi, yapay sinir ağı

Purpose To evaluate the epithelial and stromal thicknesses of conjunctiva and cornea in psoriatic patients with anterior segment optical coherence tomography (AS-OCT), Methods In this cross-sectional study, 61 patients with psoriasis and 42 age-matched, healthy individuals were enrolled. The epithelial and stromal thicknesses of both inferotemporal bulbar conjunctiva and central cornea were measured using AS-OCT. Results Both the tear breakup time and Schirmer-1 test values were significantly lower in the psoriasis group compared with the controls (p < 0.05). The epithelial thickness of conjunctiva and cornea did not differ between psoriasis and control groups (p > 0.05). The central corneal stroma was significantly thicker in the psoriasis group (p = 0.04). PASI was positively correlated with the thickness of central cornea stroma (r = 0.442, p = 0.006) in the nail psoriasis group. Conclusions Psoriasis is not associated with altered epithelial thicknesses of the cornea and conjunctiva. It is accompanied by the stromal thickening of the cornea without conjunctival stromal involvement.

Purpose: To evaluate the epithelial and stromal thicknesses of conjunctiva and cornea in psoriatic patients with anterior segment optical coherence tomography (AS-OCT),Methods: In this cross-sectional study, 61 patients with psoriasis and 42 age-matched, healthy individuals were enrolled. The epithelial and stromal thicknesses of both inferotemporal bulbar conjunctiva and central cornea were measured using AS-OCT. Results: Both the Tear break-up time and Schirmer-1 test values were significantly lower in the psoriasis group compared with the controls (p0.05) The central corneal stroma was significantly thicker in the psoriasis group (p=0.04). PASI was positively correlated with the thickness of central cornea stroma (r=0.442, p=0.006) in the nail psoriasis group. Conclusions: Psoriasis is not associated with altered epithelial thicknesses of the cornea and conjunctiva. It is accompanied by the stromal thickening of the cornea without conjunctival stromal involvement.

Purpose: To evaluate anxiety, depression status, and vision related quality of life (QoL) in patient with age-related macular degeneration (AMD) during the early phase of COVID-19 pandemic.Methods: Seventy-one voluntary patients with AMD and demografic variables matched 36 healthy controls were compared in this study. All the subjects were evaluated with the Hospital Anxiety and Depression Scale (HAD-A and HAD-D) and National Eye Institute Visual Functioning Questionnaire-25 (NEI-VFQ-25). Results: There were no statistically significant difference in HADS-A and HADS-D between the AMD group and controls (pConclusions: The AMD patients had lower vision related QoL scores during COVID-19 pandemic and it is recommended psychiatric counseling opportunities is needed for AMD patients having low binocular visual acuity.

The aim was to evaluate the corneal and bulbar conjunctival thicknesses of soft contact lens (SCL) wearers using anterior segment optical coherence tomography (AS-OCT).The epithelial and overall thicknesses of both the central cornea and the infero-temporal bulbar conjunctiva of SCL wearers (30 subjects) were obtained by Cirrus HD-OCT and compared with those of refraction-matched controls (30 subjects) and patients with emmetropia (30 subjects).The mean corneal epithelial thicknesses in SCL wearing, spectacle-wearing and emmetropic groups were 48.97 ± 5.45, 52.18 ± 4.84 and 53.18 ± 5.05 µm, respectively. The corneal epithelium of members of the SCL group was significantly thinner than in both the spectacles and emmetropic groups (p = 0.044 and 0.006, respectively), whereas the central corneal thickness did not differ between groups (p = 0.210). The mean conjunctival epithelial thicknesses in SCL, spectacles and emmetropic groups were 41.50 ± 7.75, 54.33 ± 8.39 and 49.10 ± 7.11 µm, respectively. Conjunctival epithelium in the SCL group was significantly thinner than in both spectacle-wearing and emmetropic groups (p < 0.001 and p = 0.001, respectively). The conjunctiva was significantly thinner in the SCL group compared to the spectacles group (p = 0.001) but not the emmetropic group.Contact lens wear is related to thinning of both corneal and conjunctival layers. AS-OCT is a non-invasive and clinically applicable technique for assessing the involvement of the cornea and conjunctiva in contact lens wearers.

We appreciate the interest of Uzun et al.1 in our article, “Evaluation of macular ganglion cell-inner plexiform layer and choroid in psoriasis patients using enhanced depth imaging spectral domain ...

Oleuropein is known to have anti-oxidant and anti-inflammatory effects. An important aim of anesthetic management in ocular surgery is to keep the intraocular pressure under control. Studies have researched a variety of prophylactic materials used to prevent increases in intraocular pressure. We aimed to research the effects of oleuropein on intraocular pressure (IOP) during general anaesthesia. Fourteen New Zealand rabbits were randomly divided into two groups of seven. The rabbits in Group O were given olive leaf extract (OLE) equivalent to a daily dose of 20 mg/kg oleuropein for 15 days. HPLC method used for oleuropein standardization. For anaesthesia induction 1 mg/kg rocuronium was given and after muscle relaxation all animals had a V-gel Rabbit inserted. Anesthetic maintenance was provided by 1 MAC isoflurane. Twenty minutes after rabbits were given 10 mg/kg ketamine, basal IOP values were measured. After the V-gel rabbit was inserted, in the 5th, 10th, 20th, 25th and 30th minutes measurements were repeated. IOP data variation of OLE group was compared with control group and the measured levels were lower in Group O during the anaesthesia. IOP was 33.8 ± 4 mmHg in Group C and 24.1 ± 8 mmHg in Group O in 25th minute and the difference between the two groups was statistically significant at this time. We observed that consumption of prophylactic OLE had a reducing effect on IOP in the period before waking in anaesthesia. We believe it is necessary to investigate the effects of OLE on IOP in broad participation patient groups.

Purpose: To evaluate the effects of Ramadan fasting on central foveal thickness (CFT) and subfoveal choroidal thickness (SFCT) in healthy individuals using enhanced depth imaging optical coherence tomography (EDI-OCT). Materials and Methods: The EDI-OCT scans of 42 healthy individuals obtained after about 12 hours of fasting on at least the twenty-first consecutive day of fasting were compared to scans of the same patients taken one month after the last day they had fasted. Results: CFT values were similar for both time periods (p > 0.05). The SFCT was significantly higher after consecutive fasting days towards the end of Ramadan, compared to the SFCT after one month of no fasting (one month after Ramadan ended) (p < 0.001). Conclusions: Ramadan fasting may lead to a significant increase in subfoveal choroidal thickness without affecting the central foveal thickness.