Liyuan Xu
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Liyuan Xu has a total of 6 co-authors. Here are the top co-authors by number of shared publications:
- Aiguo Chen
School of Sport and Brain Health, Nanjing Sport Institute
1 shared publication - Dandan Chen
College of Physical Education, Yangzhou University, Yangzhou 225127, China
1 shared publication - Kelong Cai
School of Sport and Brain Health, Nanjing Sport Institute, Nanjing 210014, China
1 shared publication - Lina Zhu
School of Physical Education and Sports Science, Beijing Normal University, Beijing 100000, China
1 shared publication - Linna Zhu
College of Physical Education, Yangzhou University, Yangzhou 225127, China
1 shared publication - Zhimei Liu
Department of Rehabilitation Medicine, The Affiliated Hospital of Yangzhou University, Yangzhou 225012, China
1 shared publication
Latest Publications
- Open Access
- 5 August 2021
- Published by MDPI AG in International Journal of Environmental Research and Public Health
- Vol. 18 (16) , 8283
Moderate Exercise Combined with Enriched Environment Enhances Learning and Memory through BDNF/TrkB Signaling Pathway in Rats
This study aimed to investigate the effects and potential mechanisms of exercise combined with an enriched environment on learning and memory in rats. Forty healthy male Wistar rats (7 weeks old) were randomly assigned into 4 groups (N = 10 in each group): control (C) group, treadmill exercise (TE) group, enriched environment (EE) group and the TE + EE group. The Morris water maze (MWM) test was used to evaluate the learning and memory ability in all rats after eight weeks of exposure in the different conditions. Moreover, we employed enzyme-linked immunosorbent assay (ELISA) to determine the expression of brain-derived neurotrophic factor (BDNF) and receptor tyrosine kinase B (TrkB) in the rats. The data showed that the escape latency and the number of platform crossings were significantly better in the TE + EE group compared to the TE, EE or C groups (p < 0.05). In addition, there was upregulation of BDNF and TrkB in rats in the TE + EE group compared to those in the TE, EE or C groups (p < 0.05). Taken together, the data robustly demonstrate that the combination of TE + EE enhances learning and memory ability and upregulates the expression of both BDNF and TrkB in rats. Thus, the BDNF/TrkB signaling pathway might be modulating the effect of exercise and enriched environment in improving learning and memory ability in rats.
- 5 August 2021
- Published by MDPI AG in International Journal of Environmental Research and Public Health
- Vol. 18 (16) , 8283
Open AccessModerate Exercise Combined with Enriched Environment Enhances Learning and Memory through BDNF/TrkB Signaling Pathway in Rats
This study aimed to investigate the effects and potential mechanisms of exercise combined with an enriched environment on learning and memory in rats. Forty healthy male Wistar rats (7 weeks old) were randomly assigned into 4 groups (N = 10 in each group): control (C) group, treadmill exercise (TE) group, enriched environment (EE) group and the TE + EE group. The Morris water maze (MWM) test was used to evaluate the learning and memory ability in all rats after eight weeks of exposure in the different conditions. Moreover, we employed enzyme-linked immunosorbent assay (ELISA) to determine the expression of brain-derived neurotrophic factor (BDNF) and receptor tyrosine kinase B (TrkB) in the rats. The data showed that the escape latency and the number of platform crossings were significantly better in the TE + EE group compared to the TE, EE or C groups (p < 0.05). In addition, there was upregulation of BDNF and TrkB in rats in the TE + EE group compared to those in the TE, EE or C groups (p < 0.05). Taken together, the data robustly demonstrate that the combination of TE + EE enhances learning and memory ability and upregulates the expression of both BDNF and TrkB in rats. Thus, the BDNF/TrkB signaling pathway might be modulating the effect of exercise and enriched environment in improving learning and memory ability in rats.