Isidora Minic
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Isidora Minic has a total of 8 co-authors. Here are the top co-authors by number of shared publications:
- Alessandra Renzini
DAHFMO Unit of Histology and Medical Embryology, Sapienza University of Rome, Rome, Italy
1 shared publication - Alessia Cedola
Institute of Nanotechnology - CNR, Piazzale Aldo Moro 5, Rome, Italy
1 shared publication - Biliana Lozanoska-Ochser
UniCamillus: Saint Camillus International University of Health and Medical Sciences
1 shared publication - Carles Sánchez Riera
Department of Anatomical, Histological, Forensic Sciences and Orthopedics, Sapienza University of Rome, Rome, Italy
1 shared publication - Chiara D'Ercole
Sorbonne University
1 shared publication - Giuseppe Gigli
Institute of Nanotechnology, c/o Campus Ecotekne, National Research Council (CNR-NANOTEC), Monteroni, 73100 Lecce, Italy
1 shared publication
Latest Publications
- Open Access
- 5 August 2021
- Published by MDPI AG in Metabolites
- Vol. 11 (8) , 517
Metabolic Remodeling in Skeletal Muscle Atrophy as a Therapeutic Target
Skeletal muscle is a highly responsive tissue, able to remodel its size and metabolism in response to external demand. Muscle fibers can vary from fast glycolytic to slow oxidative, and their frequency in a specific muscle is tightly regulated by fiber maturation, innervation, or external causes. Atrophic conditions, including aging, amyotrophic lateral sclerosis, and cancer-induced cachexia, differ in the causative factors and molecular signaling leading to muscle wasting; nevertheless, all of these conditions are characterized by metabolic remodeling, which contributes to the pathological progression of muscle atrophy. Here, we discuss how changes in muscle metabolism can be used as a therapeutic target and review the evidence in support of nutritional interventions and/or physical exercise as tools for counteracting muscle wasting in atrophic conditions.
- 5 August 2021
- Published by MDPI AG in Metabolites
- Vol. 11 (8) , 517
Open AccessMetabolic Remodeling in Skeletal Muscle Atrophy as a Therapeutic Target
Skeletal muscle is a highly responsive tissue, able to remodel its size and metabolism in response to external demand. Muscle fibers can vary from fast glycolytic to slow oxidative, and their frequency in a specific muscle is tightly regulated by fiber maturation, innervation, or external causes. Atrophic conditions, including aging, amyotrophic lateral sclerosis, and cancer-induced cachexia, differ in the causative factors and molecular signaling leading to muscle wasting; nevertheless, all of these conditions are characterized by metabolic remodeling, which contributes to the pathological progression of muscle atrophy. Here, we discuss how changes in muscle metabolism can be used as a therapeutic target and review the evidence in support of nutritional interventions and/or physical exercise as tools for counteracting muscle wasting in atrophic conditions.