Stefan G. J. Leuven
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Stefan G. J. Leuven has a total of 5 co-authors. Here are the top co-authors by number of shared publications:
- Loek van Heerebeek
Department of Cardiology, OLVG, 1091 AC Amsterdam, The Netherlands
1 shared publication - Michelle M. de Leau
Heart Center, Department of Cardiology, OLVG Hospital, 1091 AC Amsterdam, The Netherlands
1 shared publication - Nick D. Fagel
Heart Center, OLVG Hospital, 1091 AC Amsterdam, The Netherlands
1 shared publication - Robert K. Riezebos
Heart Center, OLVG, Amsterdam, Netherlands
1 shared publication - Wouter J. Kikkert
Department of Cardiology, Amsterdam UMC, University of Amsterdam, Amsterdam Cardiovascular Sciences , Meibergdreef 9, 1105 AZ Amsterdam
1 shared publication
Latest Publications
- Open Access
- 17 August 2021
- Published by MDPI AG in Journal of Clinical Medicine
- Vol. 10 (16) , 3636
The Effect of the Timing of Invasive Management on Cardiac Function in Patients with NSTE-ACS, Insights from the OPTIMA-2 Randomized Controlled Trial
The timing of coronary angiography in patients with non-ST-elevation acute coronary syndrome (NSTE-ACS) remains a matter of debate. The relationship between the timing of invasive management and left ventricular function (LVF) is largely unknown. The An Immediate or Early Invasive Strategy in Non-ST-Elevation Acute Coronary Syndrome trial (OPTIMA-2) was a randomized controlled prospective open-label multicenter trial that randomized 249 NSTE-ACS patients to either an immediate (p = 0.51, nor was there any difference in GLS recovery between the study groups: −0.8% (SD: 2.5) vs. −0.7% (SD 2.8) p = 0.82. If baseline and follow-up echocardiograms were compared, there was a similar but significant improvement in both EF and GLS in both separate study groups. An immediate invasive strategy in NSTE-ACS patients did not result in an improved left ventricular EF or GLS recovery compared with an early strategy.
- 17 August 2021
- Published by MDPI AG in Journal of Clinical Medicine
- Vol. 10 (16) , 3636
Open AccessThe Effect of the Timing of Invasive Management on Cardiac Function in Patients with NSTE-ACS, Insights from the OPTIMA-2 Randomized Controlled Trial
The timing of coronary angiography in patients with non-ST-elevation acute coronary syndrome (NSTE-ACS) remains a matter of debate. The relationship between the timing of invasive management and left ventricular function (LVF) is largely unknown. The An Immediate or Early Invasive Strategy in Non-ST-Elevation Acute Coronary Syndrome trial (OPTIMA-2) was a randomized controlled prospective open-label multicenter trial that randomized 249 NSTE-ACS patients to either an immediate (p = 0.51, nor was there any difference in GLS recovery between the study groups: −0.8% (SD: 2.5) vs. −0.7% (SD 2.8) p = 0.82. If baseline and follow-up echocardiograms were compared, there was a similar but significant improvement in both EF and GLS in both separate study groups. An immediate invasive strategy in NSTE-ACS patients did not result in an improved left ventricular EF or GLS recovery compared with an early strategy.