Yang Ji

In the field of bone repair, the inorganic–organic composite scaffold is a promising strategy for mimicking the compositions of the natural bone. In addition, as implants for repairing load-bearing sites, an inert permanent bone substitute composites with bioactive degradable ingredients may make full use of the composite scaffold. Herein, the porous zirconia (ZrO₂) matrix was prepared via the template replication method, and the partial degradable ZrO₂–chitosan particles–GelMA composite scaffolds with different chitosan/GelMA volume ratios were prepared through the vacuum infiltration method. Dynamic light scattering (DLS) and the scanning electron microscope (SEM) were adopted to observe the size of the chitosan particles and the morphologies of the composites scaffold. The mechanical properties, swelling properties, and degradation properties of the composite scaffolds were also characterized by the mechanical properties testing machine and immersion tests. The CCK-8 assay was adopted to test the biocompatibility of the composite scaffold preliminarily. The results show that chitosan particles as small as 60 nm were obtained. In addition, the ratio of chitosan/GelMA can influence the mechanical properties and the swelling and degradation behaviors of the composites scaffold. Furthermore, improved cell proliferation performance was obtained for the composite scaffolds.

As biodegradable medical implants, magnesium alloys have attracted great concerns due to their desirable biological and mechanical performances. Nevertheless, the overfast degradation rate of magnesium alloys makes it difficult to make full use of their potential in medical sciences. Therefore, it is a hot issue to control the degradation rate and functionalize the magnesium alloys via surface modifications. Herein, methacrylate gelatin (GelMA) hydrogel was adopted as coatings on the surface of WE43 magnesium alloys to control the degradation behaviors of magnesium alloys. Inspired by mussels, dopamine (DOPA) hydrochloride was adopted to modify GelMA to further functionalize the coatings. The compositions, swelling properties, degradation behaviors, and morphologies of samples were characterized by UV-Vis spectrophotometer, nuclear magnetic resonance (NMR), Fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM), and immersion test. It was shown that GelMA-DOPA composites could be obtained and the swelling and degradation behaviors of magnesium alloys could be controlled by adjusting the compositions of GelMA and DOPA. Furthermore, the GelMA-DOPA hydrogel coatings can be tightly bonded to the Mg alloys.

Polyetheretherketone (PEEK) is an alternative biomedical polymer material to traditional metal and ceramic biomaterials. However, as a bioinert material, its wide application in the medical field is seriously restricted due to its lack of bioactivity. In this research, pure Mg was successfully deposited on a PEEK substrate by vapor deposition to improve the antibacterial properties of PEEK implants. The morphology and elemental composition of the coating were characterized by scanning electron microscopy (SEM) and energy-dispersive spectroscopy (EDS). The higher the deposition temperature, the larger the Mg particle size. The Mg coating possesses a hydrophilic surface and a higher surface free energy that create its good biocompatibility. The Mg coating on a PEEK substrate withstands up to 56 days’ immersion. The antibacterial test showed that the antibacterial rate of coated PEEK is 99%. Mg-coated PEEK demonstrates promising antibacterial properties.