Sajid- Ul- Ghafoor
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Sajid- Ul- Ghafoor has a total of 6 co-authors. Here are the top co-authors by number of shared publications:
Aziz Ahmed
Department of Medicine, Saidu Teaching Hospital, Saidu Sharif, Swat, Pakistan
1 shared publication- Habib Ahmad
Department of Genetics, Hazara University Mansehra, Pakistan
1 shared publication I Inamullah
1 shared publication- Liaqat Ali
Division of Infectious Diseases, Department of Internal Medicine II, University Hospital Freiburg, 79106 Freiburg, Germany; Faculty of Biology, Albert Ludwigs University of Freiburg, 79104 Freiburg, Germany
1 shared publication - Muhammad Ali
Department of Biotechnology, Quaid-i-Azam University Islamabad, Islamabad, Pakistan
1 shared publication - Muhammad Idrees
Centre for Applied Molecular Biology, University of the Punjab, Lahore, Pakistan
1 shared publication
Latest Publications
- Open Access
- 14 January 2011
- Published by Springer Nature in Virology Journal
- Vol. 8 (1) , 16
Hepatitis C virus genotypes circulating in district Swat of Khyber Pakhtoonkhaw, Pakistan
Hepatitis C virus (HCV) is the leading cause of chronic hepatitis worldwide and its subtypes/genotypes are clinically important for clinical management and vaccine development. The present study describes frequency distribution of different HCV genotypes and their treatment status in HCV RNA positive patients from district Swat. A total of 185 HCV infected sera were analyzed by molecular genotyping assay. The most prevalent genotype was 3a (34.1%), followed by 2a (8.1%), 3b (7%) and 1a (5.4%). The samples found untypable by the present method of genotypes was 37.8% while, patients with mixed genotype infections were 7.6%. More than 80% of untypable cases were from those HCV patients who had received interferon plus ribavirin standard therapy in the past and either were non-responders and were relapsed thereafter or were under treatment. In conclusion, genotype 3a is the most prevalent HCV genotype in the region. A high prevalence rate of untypable genotypes is present in treated patients that need further investigation for the successful genotyping by developing new assays or using viral sequencing method.
- 14 January 2011
- Published by Springer Nature in Virology Journal
- Vol. 8 (1) , 16
Open AccessHepatitis C virus genotypes circulating in district Swat of Khyber Pakhtoonkhaw, Pakistan
Hepatitis C virus (HCV) is the leading cause of chronic hepatitis worldwide and its subtypes/genotypes are clinically important for clinical management and vaccine development. The present study describes frequency distribution of different HCV genotypes and their treatment status in HCV RNA positive patients from district Swat. A total of 185 HCV infected sera were analyzed by molecular genotyping assay. The most prevalent genotype was 3a (34.1%), followed by 2a (8.1%), 3b (7%) and 1a (5.4%). The samples found untypable by the present method of genotypes was 37.8% while, patients with mixed genotype infections were 7.6%. More than 80% of untypable cases were from those HCV patients who had received interferon plus ribavirin standard therapy in the past and either were non-responders and were relapsed thereafter or were under treatment. In conclusion, genotype 3a is the most prevalent HCV genotype in the region. A high prevalence rate of untypable genotypes is present in treated patients that need further investigation for the successful genotyping by developing new assays or using viral sequencing method.