Ming-Chieh Ma
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Ming-Chieh Ma has a total of 4 co-authors. Here are the top co-authors by number of shared publications:
- Bo-An Su
Internal Medicine, Infection Department, Chi Mei Hospital, Tainan 71004, Taiwan
1 shared publication - Jiun-Jr Wang
School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan
1 shared publication - Wen-Bin Wu
School of Medicine, Fu Jen Catholic University, New Taipei City 242062, Taiwan
1 shared publication - Wen-Yuan Du
School of Medicine Fu Jen Catholic University Taipei Taiwan
1 shared publication
Latest Publications
- Open Access
- 12 May 2024
- Published by MDPI AG in Tropical Medicine and Infectious Disease
- Vol. 9 (5) , 111
IL-33 Enhances the Total Production of IgG, IgG1, and IgG3 in Angiostrongylus cantonensis-Infected Mice
The purpose of this study is to clarify the role of IL-33 in the immune response to angiostrongyliasis, especially in terms of antibody production and isotype switching. In our experiment, C57BL/6 mice were each infected with 35 infectious larvae and were divided into groups that received an intraperitoneal injection of IL-33, anti-IL-33 monoclonal antibody (mAb), or anti-ST2 mAb 3 days post-infection (dpi) and were subsequently administered booster shots at 5-day intervals with the same dose. Serum samples from each group were collected weekly for ELISA assays. The levels of total IgG, IgG1, and IgG3 were significantly increased in A. cantonensis-infected mice that were treated with IL-33, and the levels decreased significantly in infected groups treated with anti-IL-33 or anti-ST2 mAb. These results suggest that IL-33 may play a critical role in the pathogenesis of human angiostrongyliasis and could be useful for understanding protective immunity against this parasitic infection.
- 12 May 2024
- Published by MDPI AG in Tropical Medicine and Infectious Disease
- Vol. 9 (5) , 111
Open AccessIL-33 Enhances the Total Production of IgG, IgG1, and IgG3 in Angiostrongylus cantonensis-Infected Mice
The purpose of this study is to clarify the role of IL-33 in the immune response to angiostrongyliasis, especially in terms of antibody production and isotype switching. In our experiment, C57BL/6 mice were each infected with 35 infectious larvae and were divided into groups that received an intraperitoneal injection of IL-33, anti-IL-33 monoclonal antibody (mAb), or anti-ST2 mAb 3 days post-infection (dpi) and were subsequently administered booster shots at 5-day intervals with the same dose. Serum samples from each group were collected weekly for ELISA assays. The levels of total IgG, IgG1, and IgG3 were significantly increased in A. cantonensis-infected mice that were treated with IL-33, and the levels decreased significantly in infected groups treated with anti-IL-33 or anti-ST2 mAb. These results suggest that IL-33 may play a critical role in the pathogenesis of human angiostrongyliasis and could be useful for understanding protective immunity against this parasitic infection.