Chi Chou
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Chi Chou has a total of 5 co-authors. Here are the top co-authors by number of shared publications:
- Chi-Chen Fan
Department of Physiology, Mackay Memorial Hospital, Taipei, Taiwan,
1 shared publication - Chi-Yuan Tzen
Department of Pathology, Mackay Memorial Hospital, Taipei, Taiwan
1 shared publication - Liek-Yeow Lee
Institute of Biochemical Sciences, College of Life Science, National Taiwan University, Taipei, Taiwan
1 shared publication - Mau-Sun Chang
Affiliations Institute of Biochemical Sciences, National Taiwan University, Taipei, Taiwan, Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan
1 shared publication - Ming-Ying Yu
Institute of Biochemical Sciences, College of Life Science, National Taiwan University, Taipei, Taiwan
1 shared publication
Latest Publications
- 28 April 2013
- Published by Springer Nature in Tumor Biology
- Vol. 34 (5) , 2557-2564
Upregulated hPuf-A promotes breast cancer tumorigenesis
HPuf-A is a member of RNA-binding PUF family that regulates mRNA translation. Redistribution of hPuf-A from the nucleolus to the nucleoplasm upon genotoxic stress modulates the poly(ADP-ribosyl)ation activity of PARP-1. Here, we report a novel function of hPuf-A involved in promoting breast cancer progression. Immunohistochemical studies showed higher expression levels of hPuf-A in stage I, II, III, and IV breast cancer specimens in contrast with those of hPuf-A in ductal carcinoma in situ. The presence of hPuf-A is highly associated with colony formation capacities in breast cancer T47D and MDA-MB-231 cells. Xenograft growth of hPuf-A-silenced and hPuf-A overexpressing MDA-MB-231 cells in nude mice was substantially in concert with colony formation capacities. This promoting effect of hPuf-A in tumorigenesis might be correlated with the regulation of its associated mRNAs, such as RbAp48 and DDX3. Collectively, hPuf-A may have diagnostic values in breast cancer progression.
- 28 April 2013
- Published by Springer Nature in Tumor Biology
- Vol. 34 (5) , 2557-2564
Upregulated hPuf-A promotes breast cancer tumorigenesis
HPuf-A is a member of RNA-binding PUF family that regulates mRNA translation. Redistribution of hPuf-A from the nucleolus to the nucleoplasm upon genotoxic stress modulates the poly(ADP-ribosyl)ation activity of PARP-1. Here, we report a novel function of hPuf-A involved in promoting breast cancer progression. Immunohistochemical studies showed higher expression levels of hPuf-A in stage I, II, III, and IV breast cancer specimens in contrast with those of hPuf-A in ductal carcinoma in situ. The presence of hPuf-A is highly associated with colony formation capacities in breast cancer T47D and MDA-MB-231 cells. Xenograft growth of hPuf-A-silenced and hPuf-A overexpressing MDA-MB-231 cells in nude mice was substantially in concert with colony formation capacities. This promoting effect of hPuf-A in tumorigenesis might be correlated with the regulation of its associated mRNAs, such as RbAp48 and DDX3. Collectively, hPuf-A may have diagnostic values in breast cancer progression.