Batuhan Aslan

Background: Endometrial thickness (EMT) is a key predictor of success in frozen-thawed embryo transfer (FET), but a 'thin' endometrium often poses clinical dilemmas regarding cycle progression. Recent evidence suggests that endometrial compaction—a decrease in EMT after progesteroneexposure—may reflect physiological receptivity rather than pathological thinning. However, its prognostic value in patients with thin EMT on transfer day is not yet established.Objectives: To assess the impact of endometrial compaction on live birth rates (LBR) in women with thin EMT (

Purpose:  To investigate the histopathological association between chronic endometritis (CE) and adenomyosis, focusing onbasal endometrial alterations and the potential involvement of tissue injury and repair (TIAR) mechanisms. Methods:  This retrospective case–control study included 146 propensity score-­ matched hysterectomy specimens (73 adenomy-osis, 73 controls). CE was diagnosed via CD38 immunohistochemical staining, identifying ≥ 5 plasma cells per high-­ power field.Basal endometrial thickness was measured digitally at the endo-­ myometrial junction. Basal endometrial loss was defined as theabsence of the basal layer in at least two of three regions. Results:  CE was significantly more frequent in the adenomyosis group (23.3%) than in controls (9.6%; p 0.028). Basal endo-metrial loss, observed in 23.3% of cases, was strongly associated with CE (47% vs. 7.1%; p < 0.001). In patients with measurablethickness, a 0.15 mm cutoff predicted CE with AUC 0.888 (sensitivity 83.3%, specificity 86.9%). In multivariate analysis, basalendometrial loss was an independent risk factor for CE (adjusted OR 10.45, 95% CI 4.12–26.51; p < 0.001). Conclusions:  CE is significantly associated with adenomyosis. Basal endometrial loss may mediate this relationship throughTIAR-­ related mechanisms, suggesting CE as a potential therapeutic target in adenomyosis

Undefined - Journal of the Turkish-German Gynecological Association

Purpose: To investigate the histopathological association between chronic endometritis (CE) and adenomyosis, focusing on basal endometrial alterations and the potential involvement of tissue injury and repair (TIAR) mechanisms. Methods: This retrospective case–control study included 146 propensity score‐matched hysterectomy specimens (73 adenomyosis, 73 controls). CE was diagnosed via CD38 immunohistochemical staining, identifying ≥ 5 plasma cells per high‐power field. Basal endometrial thickness was measured digitally at the endo‐myometrial junction. Basal endometrial loss was defined as the absence of the basal layer in at least two of three regions. Results: CE was significantly more frequent in the adenomyosis group (23.3%) than in controls (9.6%; p = 0.028). Basal endometrial loss, observed in 23.3% of cases, was strongly associated with CE (47% vs. 7.1%; p < 0.001). In patients with measurable thickness, a 0.15 mm cutoff predicted CE with AUC 0.888 (sensitivity 83.3%, specificity 86.9%). In multivariate analysis, basal endometrial loss was an independent risk factor for CE (adjusted OR 10.45, 95% CI 4.12–26.51; p < 0.001). Conclusions: CE is significantly associated with adenomyosis. Basal endometrial loss may mediate this relationship through TIAR‐related mechanisms, suggesting CE as a potential therapeutic target in adenomyosis.

Ethanol sclerotherapy (EST) has gained attention as a minimally invasive treatment option for ovarian endometriomas, particularly in infertile women with endometrioma undergoing in vitro fertilization (IVF). Endometriomas are associated with decreased ovarian reserve and impaired fertility outcomes, and traditional surgical approaches, such as cystectomy, often lead to further reductions in ovarian reserve. Ethanol sclerotherapy offers a potential alternative that preserves ovarian function while effectively managing endometriomas. This review examines the safety, efficacy, and impact of EST on ovarian reserve, IVF outcomes, and recurrence rates. Comparative studies suggest that pregnancy rates following EST are similar to or better than those after cystectomy, with the added benefit of more oocytes retrieved, which may lead to higher cumulative live birth rates. Despite these promising results, challenges such as recurrence and complications, particularly with prolonged ethanol exposure, remain. The use of transvaginal versus laparoscopic approaches and optimal ethanol exposure protocols are areas of ongoing research. The need for further large-scale, prospective studies is highlighted to refine the EST protocol and better understand the long-term outcomes. Sclerotherapy presents a feasible option for preserving fertility in women with endometriomas, with positive implications for IVF success and ovarian reserve preservation.