Yi Luan

Polyunsaturated fatty acids (PUFAs) play a crucial role in tumor development by influencing not only tumor cells but also immune cells within the tumor microenvironment. Here, we explored the mechanisms by which PUFAs are transported and function within immune cells to regulate tumor growth. We found that PUFA transport through LDL receptor–related protein 5 (LRP5) into natural killer (NK) cells played an essential role in modulating the cells’ antitumor function. LRP5 deficiency or expression of LRP5 lacking the LDLa domain enhanced the cytotoxicity and antitumor activity of NK cells both in vivo and in culture. However, wild-type NK cells cultured in the absence of PUFAs and NK cells from mice fed a PUFA-free diet also exhibited enhanced cytotoxicity, eliminating the functional difference between wild-type and NK cells expressing LDLa domain–deficient LRP5. Mechanistically, LRP5-mediated PUFA transport suppressed mTORC1 signaling and glycolysis in NK cells, a metabolic pathway essential for NK cell cytotoxicity. Thus, our study identified LRP5 as an immune checkpoint that restrains NK cell activity through PUFA transport–dependent suppression of mTORC1 signaling.

MAP3K inhibition attenuates acute lung injuries in mice and reduced edema in lung transplantation recipients.

Background: Non‐human primates, when encountering human beings, show wariness and alertness. These behaviors differ when there is direct human gaze vs. when human averts his gaze.Methods: We observed cynomolgus monkey in their home cage and studied their behaviors in response to human gaze. Four behaviors were analyzed: opening mouth, staring at observer, agitated activity, and approaching observer.Results: Three behaviors appeared to be sensitive to human gaze between when the human observer gazed at the monkey and when the human observer looked away. Individual animals also displayed subpatterns of responses to human gaze.Conclusions: These results indicate that, even in their home cage, monkeys display a heightened level of awareness when gazed upon by a human observer, suggesting that human gaze may elicit emotional reactions. Further, under the human gaze, distinct behavioral subpatterns were apparent within the monkey cohort in our study, indicative of subgroups within the cohort.