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RESUMO Este estudo teve como objetivo analisar e descrever as características epidemiológicas e obstétricas dos casos de óbitos maternos por covid-19 no estado do Pará, durante os anos de 2020 e 2021. Trata-se de uma pesquisa quantitativa, transversal, descritiva e retrospectiva, baseada em 78 casos notificados de óbitos maternos, com dados secundários provenientes da Secretaria de Estado de Saúde Pública do Pará. As variáveis incluíram fatores epidemiológicos e obstétricos, sendo aplicadas análises descritivas, teste Qui-quadrado (p<0,05) e regressão logística com cálculo da Odds Ratio (OR). Observou-se que 62,8% dos óbitos ocorreram em 2021, e 78,2% no puerpério. A maioria das mulheres teve até três gestações (74,4%), partos (79,5%) e nenhuma ocorrência de aborto (79,5%). A ausência de pré-natal elevou em 3,96 vezes o risco de óbito (p=0,037), enquanto a realização de cesariana aumentou o risco em 2,74 vezes (p=0,045). Verificou-se maior vulnerabilidade entre mulheres com maior número de gestações e partos. Conclui-se que o déficit na assistência pré-natal e as condições obstétricas adversas contribuíram para o aumento da mortalidade materna por covid-19, reforçando a necessidade de políticas públicas voltadas à ampliação do acesso e da qualidade do cuidado materno, especialmente em regiões com fragilidades estruturais como o Pará.

Book Brazil in Advancing Pharmacotherapy and Clinical Pharmacy in Latin America Proceedings of the Fourth Brazilian Congress of Pharmacotherapy and Clinical Pharmacy doi: 10.62922/4cbffc ISBN: 978-65-983944-2-4 Editors Wallace Entringer Bottacin – ORCID | Lattes | Google Scholar Thaís Teles de Souza – ORCID | Lattes Walleri Christini Torelli Reis – ORCID | Lattes | Google […]

Hyaluronic acid (HA) is an endogenous substance present in various tissues and biological fluids. Due to its physicochemical properties, it contributes to many biological processes at intra and extracellular levels, such as skin hydration, joint lubrication and wound healing, in addition to its anti-inflammatory and antioxidant effects. For this reason, HA has been applied as an anti-aging molecule in the form of cosmetic products. In this way, the present article aimed, through a bibliographic review, to describe the benefits of the different pharmaceutical forms with hyaluronic acid in the management of skin aging. This is a narrative review of the literature, which allowed the authors to present the different attributes of hyaluronic acid in different pharmaceutical formulations in the fight against aging. As a technical procedure, the health descriptors “hyaluronic acid”, “pharmaceutical forms”, “benefits of hyaluronic acid” and “indications with hyaluronic acid” were used. The results obtained allowed observing that hyaluronic HA has become one of the most promising actives against skin aging, being present in different cosmetic formulations, and can be found in moisturizers and protectors. Therefore, the evidence on the results allows us to state that the different pharmaceutical forms containing HA result in several benefits in preventing skin aging.             

The present paper carried out an integrative review about the clinical studies on Hibiscus sabdariffa L., as a therapeutic alternative in the treatment of obesity. This is an integrative literature review, carried out in 6 phases that consisted of: i) identification of the theme; ii) formulation of the guiding question; iii) literature search; iv) categorization of the studies found; v) analysis of included studies and vi) interpretation of results. The search for articles was carried out through the BVS, SCIELO and PubMed databases, using the descriptors “Hibiscus sabdariffa”, “medicinal plants”, “obesity”, “clinical studies”, linked by the Boolean operators “AND” and “OR”. Initially, 11 articles were found, which after applying the inclusion and exclusion criteria, resulted in 3 analyzed articles. The results showed that the extract with HS reduces body weight, BMI, body fat, as well as decreases the distribution of abdominal fat in several female and male patients at different ages, as well as reduced diastolic and systolic pressures. Another relevant finding was the association between HS and LC, the results revealed a significant difference in anthropometric parameters in patients treated with both plants. Thus, it is concluded that the use of HS as a therapeutic alternative in the treatment of obesity is viable and effective, and that when associated with LC, the anthropometric effects are enhanced.

The life expectancy of the population has increased and improved over the years due to the quality of living conditions, housing and health. However, it is understandable that the elderly are susceptible to multiple diseases due to a variety of factors. It is known that due to the high prevalence of non-communicable chronic diseases, the use of drugs has increased significantly, accompanied by higher incidences of polypharmacy. Therefore, pharmaceutical care in elderly and polydrug populations is extremely important for monitoring, not only to promote the rational use of drugs, but also to provide better adherence to treatment and, consequently, better clinical and economic results. In this way, the present research is an integrative review to analyze evidence in the literature regarding the role of the clinical pharmacist in pharmaceutical care, as well as their interventions and the impacts caused on polymedicated elderly. For this, data collection was carried out from secondary sources, through a bibliographic survey in national and international databases. 834 articles were found, and only 20 studies were used for the present research. The results obtained in this study can demonstrate that the performance of pharmaceutical care and its intervention in geriatric and polymedicated patients can adjust doses, reduce drug interactions and reduce costs, in addition to improving the quality of life of these patients.

Chagas disease consists of a systemic infection of essentially chronic evolution caused by the flagellate protozoan Trypanosoma cruzi, which has as its vector the beetle of the triatome genus known as kissing bug. In Brazil, epidemiological data show high numbers of oral transmission, mainly in the Northern region. In the state of Pará, diagnosed cases of oral infection are mostly related to the consumption of assai (Euterpe oleracea), and are on the rise, which reinforces the need for surveillance and control strategies against the aggravation of the disease. This research aimed to organize data through a bibliographical review referring to Chagas disease infection transmitted by the consumption of assai in the city of Belém, Pará, in the last 10 years. The researched articles were categorical in relating the consumption of assai to the transmission of Chagas disease in the Amazon region, especially in the city of Belém/PA, either by confirming cases through outbreaks or diagnostic experiments of T. cruzi in assai samples. Cases are presented through sporadic outbreaks, however there is suspicion of widespread underreporting. Different authors converged on the fact that it is necessary to qualify the agents involved in the assai production chain, in order to reduce contagion through this food. The main solution seems to lie in educating both consumers and producers.

Objective: To analyze the profile of the student body of a private college in the city of Belém/PA, regarding the indiscriminate use of antibiotics and bacterial resistance. Methodology: A descriptive, quantitative, and qualitative research was carried out, which made it possible to analyze the profile of the 207 participants. Anonymously, without collecting personal data, the participation of students from pharmacy, nursing, physiotherapy, biomedicine, law, administration, and engineering courses was obtained, with data collected through a questionnaire prepared through the Google Forms platform. Results: In general, most students had knowledge about the irrational use of antibiotics and bacterial resistance, claiming to be in accordance with the RDC 20/2011 legislation, however most reported using antibiotic therapy empirically, without medical advice. The other answers obtained to the applied questions point to the same line of results, where most of the public under study is aware of the importance of complying with an antimicrobial treatment for the correct time and are in accordance with the need for the medical prescription to purchase this medication. drug class. Conclusion: The research showed positive results regarding the degree of knowledge of academics about the topic under discussion, but in contradiction, most respondents reported self-medication practices. With this, it was possible to draw a profile of informed individuals, but not yet sufficiently aware of the dimension of the growing public health problem which has become the spread of multidrug-resistant bacterial strains.

Ketamine, also called ‘K-powder’ by abusers, an analog of phencyclidine, primarily acts as an antagonist of N-methyl-D-aspartic acid (NMDA) receptors, therapeutically used as an anesthetic agent. Ketamine also stimulates the limbic system, inducing hallucinations and dissociative effects. At sub-anesthetic doses, ketamine also displays hallucinatory and dissociative properties, but not loss of consciousness. These behavioral consequences have elicited its recreational use worldwide, mainly at rave parties. Ketamine is generally a drug of choice among teenagers and young adults; however, the harmful consequences of its recreational use on adolescent central nervous systems are poorly explored. Thus, the aim of the present study was to characterize the behavioral and biochemical consequences induced by one binge-like cycle of ketamine during the early withdrawal period in adolescent female rats. Adolescent female Wistar rats (n = 20) received intraperitoneally administered ketamine (10 mg/kg/day) for 3 consecutive days. Twenty-four hours after the last administration of ketamine, animals were submitted to behavioral tests in an open field, elevated plus-maze, and forced swimming test. Then, animals were intranasally anesthetized with 2% isoflurane and euthanized to collect prefrontal cortex and hippocampus to assess lipid peroxidation, antioxidant capacity against peroxyl radicals, reactive oxygen species, reduced glutathione, and brain-derived neurotrophic factor (BDNF) levels. Our results found that 24 h after recreational ketamine use, emotional behavior disabilities, such as anxiety- and depression-like profiles, were detected. In addition, spontaneous ambulation was reduced. These negative behavioral phenotypes were associated with evidence of oxidative stress on the prefrontal cortex and hippocampus.

Binge drinking intake is the most common pattern of ethanol consumption by adolescents, which elicits emotional disturbances, mainly anxiety and depressive symptoms, as well as cognitive alterations. Ethanol exposure may act on the adenosine neuromodulation system by increasing adenosine levels, consequently increasing the activation of adenosine receptors in the brain. The adenosine modulation system is involved in the control of mood and memory behavior. However, there is a gap in the knowledge about the exact mechanisms related to ethanol exposure’s hazardous effects on the immature brain (i.e., during adolescence) and the role of the adenosine system thereupon. The present review attempts to provide a comprehensive picture of the role of the adenosinergic system on emotional and cognitive disturbances induced by ethanol during adolescence, exploring the potential benefits of caffeine administration in view of its action as a non-selective antagonist of adenosine receptors.