Chi-Chin Lum
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Chi-Chin Lum has a total of 8 co-authors. Here are the top co-authors by number of shared publications:
- Chang-Wei Hsieh
Department of Food Science and Biotechnology, National Chung Hsing University, Taichung City 402202, Taiwan
1 shared publication - Hsing-Chun Kuo
Department of Nursing, Division of Basic Medical Sciences, Chang Gung University of Science and Technology, Chiayi, Taiwan; Research Fellow, Chang Gung Memorial Hospital, Chiayi, Taiwan; Center for Drug Research and Development, Chang Gung University of Science and Technology, Taoyuan, Taiwan; Chronic Diseases and Health Promotion Research Center, Chang Gung University of Science and Technology, Chiayi, Taiwan
1 shared publication - Hui-Wen Lin
Department of Optometry, Asia University, Taichung 41354, Taiwan
1 shared publication - Kai-Di Hsu
Institute of Biotechnology, National Taiwan University, Taipei 106, Taiwan
1 shared publication - Kuan-Chen Cheng
Institute of Biotechnology, National Taiwan University, Taipei 10617, Taiwan
1 shared publication - Shin-Ping Lin
School of Food Safety, Taipei Medical University, Taipei 11031, Taiwan
1 shared publication
Latest Publications
- Open Access
- 19 October 2021
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 22 (20) , 11251
Ganoderma formosanum Exopolysaccharides Inhibit Tumor Growth via Immunomodulation
Ganoderma formosanum (GF) is a medicinal mushroom endemic to Taiwan. Previous research established the optimal culture conditions to produce exopolysaccharide rich in β-glucan (GF-EPS) from submerged fermentation of GF. The present study investigated the antitumor effects of GF-EPS in a Lewis lung carcinoma cell (LLC1) tumor-bearing mice model. In the preventive model, GF-EPS was orally administered to mice before LLC1 injection. In the therapeutic model, GF-EPS oral administration was initiated five days after tumor cell injection. The tumor size and body weight of the mice were recorded. After sacrifice, the lymphocyte subpopulation was analyzed using flow cytometry. Spleen tissues were used to analyze cytokine mRNA expression. The results showed that GF-EPS (80 mg/kg) effectively suppressed LLC1 tumor growth in both the preventive and therapeutic models. GF-EPS administration increased the proportion of natural killer cells in the spleen and activated gene expression of several cytokines. Our results provide evidence that GF-EPS promotes tumor inhibition through immunomodulation in tumor-bearing mice.
- 19 October 2021
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 22 (20) , 11251
Open AccessGanoderma formosanum Exopolysaccharides Inhibit Tumor Growth via Immunomodulation
Ganoderma formosanum (GF) is a medicinal mushroom endemic to Taiwan. Previous research established the optimal culture conditions to produce exopolysaccharide rich in β-glucan (GF-EPS) from submerged fermentation of GF. The present study investigated the antitumor effects of GF-EPS in a Lewis lung carcinoma cell (LLC1) tumor-bearing mice model. In the preventive model, GF-EPS was orally administered to mice before LLC1 injection. In the therapeutic model, GF-EPS oral administration was initiated five days after tumor cell injection. The tumor size and body weight of the mice were recorded. After sacrifice, the lymphocyte subpopulation was analyzed using flow cytometry. Spleen tissues were used to analyze cytokine mRNA expression. The results showed that GF-EPS (80 mg/kg) effectively suppressed LLC1 tumor growth in both the preventive and therapeutic models. GF-EPS administration increased the proportion of natural killer cells in the spleen and activated gene expression of several cytokines. Our results provide evidence that GF-EPS promotes tumor inhibition through immunomodulation in tumor-bearing mice.