Jayaram Vankudoth
Research Subjects
Jayaram Vankudoth has a total of 4 co-authors. Here are the top co-authors by number of shared publications:
Gangavaram V. M. Sharma
Department of Organic Synthesis & Process Chemistry, CSIR-Indian Institute of Chemical Technology
1 shared publicationGattu Sridhar
Department of Organic Synthesis & Process Chemistry, CSIR-Indian Institute of Chemical Technology
1 shared publicationManoranjan Kerketta
Department of Organic Synthesis & Process Chemistry, CSIR-Indian Institute of Chemical Technology
1 shared publicationMaruti Mali
Department of Organic Synthesis & Process Chemistry, CSIR-Indian Institute of Chemical Technology
1 shared publication
Latest Publications
- 18 October 2021
- Published by Taylor & Francis in Polycyclic Aromatic Compounds
- Vol. 42 (9) , 6750-6759
Synthesis of Tri-Substituted Olefin Derivatives from 1-Alkene-1,2-Diboronic Esters via Sequential Suzuki-Suzuki Coupling Reaction and Their Biological Activity
Substituted Olefin-based compounds are attractive targets in the design of novel chemical structures for the discovery of new drugs. In the current study, we have synthesized a series of new tri-substituted olefin derivatives (4a–4p) and their chemical structures were confirmed by spectroscopic techniques. The series of molecules were evaluated for anti-cancer potential against four human cancer cell lines such as MDA-MB-232, HepG2, MCF-7 and HEK293. Among the evaluated compounds, ten compounds 4a, 4c, 4d, 4f, 4g, 4h, 4k, 4l, 4m and 4p displayed more potent anticancer activity. Along with anti-cancer we evaluated antimalarial activity of all compounds toward plasmodial strain PF3D7 via SYBR Green I assay approach and screened their Anti tuberculosis interest toward Mycobacterium tuberculosis. Graphical Abstract
- 18 October 2021
- Published by Taylor & Francis in Polycyclic Aromatic Compounds
- Vol. 42 (9) , 6750-6759
Synthesis of Tri-Substituted Olefin Derivatives from 1-Alkene-1,2-Diboronic Esters via Sequential Suzuki-Suzuki Coupling Reaction and Their Biological Activity
Substituted Olefin-based compounds are attractive targets in the design of novel chemical structures for the discovery of new drugs. In the current study, we have synthesized a series of new tri-substituted olefin derivatives (4a–4p) and their chemical structures were confirmed by spectroscopic techniques. The series of molecules were evaluated for anti-cancer potential against four human cancer cell lines such as MDA-MB-232, HepG2, MCF-7 and HEK293. Among the evaluated compounds, ten compounds 4a, 4c, 4d, 4f, 4g, 4h, 4k, 4l, 4m and 4p displayed more potent anticancer activity. Along with anti-cancer we evaluated antimalarial activity of all compounds toward plasmodial strain PF3D7 via SYBR Green I assay approach and screened their Anti tuberculosis interest toward Mycobacterium tuberculosis. Graphical Abstract