Yupeng Li

1. The production paradigm is shifting from mass customisation to mass personalisation (Lan et al. 2025; Sun et al. 2025; Zhang et al. 2024), resulting in shorter product life cycles and more frequ...

Flotation workshop ventilation control virtual monitoring system alarm interfaces need to adapt to high-dynamic and high-interference industrial environments, while traditional interfaces have information overload and chaotic layout, leading to excessive cognitive load of operators and low alarm response efficiency, which makes it urgent to optimize the interface design. This study constructed a scenario characteristics-cognitive requirements-interface design coupling model, and conducted a 3 (alarm position) × 2 (display form) × 2 (target quantity) within-subjects experiment combined with eye-tracking technology and the NASA-TLX scale. The combination of “display beside 3D model + background color filling” performed optimally, with the single-target task achieving a 2.067 s reaction time and 99.5% accuracy, and the multi-target task 2.460 s and 94.6% accuracy, significantly reducing extraneous cognitive load. This study proposed optimization strategies including display optimization and lightweight presentation, enriching the application of Cognitive Load Theory in high-risk industrial interfaces and providing scientific references for similar system design.

Post-inflammatory hyperpigmentation (PIH) is a reaction process caused by an increase in melanin or abnormal melanin distribution due to inflammatory skin diseases, skin disease treatments, and external stimuli. Ultraviolet radiation can exacerbate PIH. It stimulates melanocytes, increases melanin production and deposition, and deepens the color and prolongs the duration of PIH. This study aims to investigate the inhibitory effects of Coelonin, an extract from Dendrobium officinale, on melanin production and its underlying mechanisms. Through molecular docking analysis, we found that Coelonin has significantly stronger binding capabilities to tyrosinase (TYR) and melanocortin 1 receptor (MC1R) than kojic acid, a well-known whitening agent. This stronger binding ability suggests that Coelonin may inhibit melanin production by regulating the activity of melanin metabolism-related proteins, thereby exerting its whitening effect. Compared with kojic acid, Coelonin demonstrates superior binding characteristics at the molecular level, providing stronger evidence for its potential as a whitening active ingredient. In cell experiments, Coelonin had no significant effect on the proliferation of B16-F10 melanoma cells within the concentration range of 20–40 µM, but it could significantly reduce the intracellular reactive oxygen species (ROS) levels and inhibit TYR activity and melanin production. Western blot results showed that Coelonin could downregulate the expression of TYR, MITF, TRP-1, and TRP-2 proteins. In in vivo experiments, a guinea pig model of PIH was established by Ablative Fractional Resurfacing CO₂ Laser (AFR CO₂) combined with UV-B irradiation. It was found that Coelonin treatment could significantly improve skin pigmentation, reduce melanin granule deposition, and did not cause skin inflammation or hyperplasia and other side effects. This study indicates that Coelonin is an efficient and safe melanin synthesis inhibitor and has the potential to be developed as a plant-derived skin whitening agent.