David L. Mitchell
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Previous Organizations / Institutes
The organizations / institutes from the scholar's other articles in the past ten years
Research Subjects
David L. Mitchell has a total of 3 co-authors. Here are the top co-authors by number of shared publications:
- Anders Johannes Hansen
GLOBE Institute, University of Copenhagen, Copenhagen K, Denmark
1 shared publication - Eske Willerslev
University of Copenhagen
1 shared publication Thomas R. Berton
Department of Carcinogenesis, University of Texas M.D. Anderson Cancer Center, Smithville, TX, USA
1 shared publication
Latest Publications
- 23 July 2012
- Published by Springer Nature
- Vol. 920, 177-187
Quantification of DNA Photoproducts in Mammalian Cell DNA Using Radioimmunoassay
Over the past 25 years, the use of polyclonal and monoclonal antibodies to quantify DNA damage has burgeoned. Immunoassays offer distinct advantages over other analytical procedures currently used to measure DNA damage including adaptability, sensitivity, and selectivity. This combination of attributes allows for the development of powerful analytical techniques to visualize and quantify specific types of DNA damage in cells, tissue, and organisms exposed to subtoxic levels of xenobiotics with distinct advantages over the other procedures in the analysis of DNA damage in human and environmental samples. Radioimmunoassay (RIA) is readily applied to a variety of biological materials and has typically been used to measure DNA damage in cell and organ cultures, tissue sections and biopsies, buccal cells, bone marrow aspirates, peripheral blood lymphocytes, and urine. Here we describe the use of a very sensitive RIA for the specific quantitation of cyclobutane dimers and (6-4) photoproducts in DNA extracted from mammalian cells and tissues.
- 23 July 2012
- Published by Springer Nature
- Vol. 920, 177-187
Quantification of DNA Photoproducts in Mammalian Cell DNA Using Radioimmunoassay
Over the past 25 years, the use of polyclonal and monoclonal antibodies to quantify DNA damage has burgeoned. Immunoassays offer distinct advantages over other analytical procedures currently used to measure DNA damage including adaptability, sensitivity, and selectivity. This combination of attributes allows for the development of powerful analytical techniques to visualize and quantify specific types of DNA damage in cells, tissue, and organisms exposed to subtoxic levels of xenobiotics with distinct advantages over the other procedures in the analysis of DNA damage in human and environmental samples. Radioimmunoassay (RIA) is readily applied to a variety of biological materials and has typically been used to measure DNA damage in cell and organ cultures, tissue sections and biopsies, buccal cells, bone marrow aspirates, peripheral blood lymphocytes, and urine. Here we describe the use of a very sensitive RIA for the specific quantitation of cyclobutane dimers and (6-4) photoproducts in DNA extracted from mammalian cells and tissues.
- 1 April 2005
- Published by Elsevier in Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
- Vol. 571 (1-2) , 265-276
Damage and repair of ancient DNA
- 1 April 2005
- Published by Elsevier in Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
- Vol. 571 (1-2) , 265-276
Damage and repair of ancient DNA