Piyawat Kantagowit

Objective: To examine how product popularity and pricing are associated with customer satisfaction across pain-relief device types on online e-commerce platforms. Methods: A cross-sectional study was conducted to analyze pain-relief products from Amazon and Best Buy. Data were collected via automated web scraping, verified, and categorized into 10 device types. Key variables including product names, prices, customer ratings, and review volumes were assessed in multivariable regression models. Results: A total of 378 distinct pain-relief products were analyzed. The median customer ratings for pain-relief devices varied significantly by type, ranging from 3.2 to 4.5 (p < 0.001). TENS units and cold/heat therapy packs achieved the highest median ratings of 4.5 (4.3– 4.6). In contrast, hand/arm massagers received the lowest median rating of 3.2 (2.2– 4.2). Pricing differences across device types were significant (p < 0.001), with neck stretchers being the least expensive (median: $29.99) and hand/arm massagers being the most expensive (median: $249.50). Discussion: Although price and the number of reviews were not significant predictors of customer ratings in multivariable regression models, significant interactions were observed between price and device type for hand/arm massagers (p < 0.001) and massage guns (p = 0.006). Additionally, significant interactions between the number of reviews and device type were observed for hand/arm massagers (p = 0.004). Conclusion: Although pricing and review quantity were not significant predictors of satisfaction for most devices, they did interact with specific categories such as hand/arm massagers and massage guns. These findings indicate that customer satisfaction is driven more by device-specific characteristics than by price or review volume.

Introduction Medial tarsometatarsal (TMT) injuries have often occurred. One of complications is post-traumatic osteoarthritis (PTOA). The Actual incidence of PTOA is still unknown and risk factors is no definite consensus. This systematic review and meta-analysis aim to examine the actual incidence of PTOA and determine the actual factors related following medial Lisfranc injuries. Method The systematic review were performed according to PRISMA guidelines. The search terms were searcheed in PubMed and Google Scholar. From an initial search,1532 studies were found ,14 eligible studies were selected for further review. The meta-analysis results were extracted and reported by the Forest plots model. Levels of heterogeneity were also evaluated from the eligible studies. Result A total of 686 patients was included. The primary outcome is actual incidences of PTOA following medial TMT injuries was 33% . The secondary outcomes were the actual factors affecting higher severity of PTOA. This result revealed non-anatomical reduction could be a risk factor of PTA significantly. The percentage of Myerson classification ≥ C was identified as a source of prevalence of PTOA in the meta-regression method. Conclusion PTOA following the medial TMT injuries occurred about 33% with mean follow-up time about 60 months. Non-anatomical reduction was a single factor that increased overall PTOA rate. Higher severity of injury (Myerson classification type C or higher severity type) and non-anatomical reduction increased the rate of severe PTOA. Anatomical reduction is recommended in the patients with medial TMT injury.

Lichen sclerosus (LS) is a chronic inflammatory skin disease affecting both genital and extra-genital areas and is found predominantly in female patients. The relationship between LS and thyroid diseases remains unclear, with conflicting evidence reported in the literature. This systematic review and meta-analysis aimed to investigate the association between LS and thyroid diseases rigorously. We conducted a comprehensive search using two electronic databases, MEDLINE and Embase, from inception to May 2024, to identify observational studies investigating the relationship between LS and thyroid diseases. A random-effects model was used to meta-analyse the pooled odds ratio with a 95% confidence interval (CI) from the included articles. A total of 14 observational articles encompassing 22,112,979 participants were included. Nine of these studies included only female participants. The analysis revealed that LS was significantly associated with an increased risk of autoimmune thyroid diseases, with an odds ratio of 2.38 (95% CI, 1.46-3.86; I² = 84%). Additionally, an association was found between hyperthyroidism and an odds ratio of 2.01 (95% CI, 1.40-2.88; I² = 0%). Furthermore, patients with LS exhibited a non-significant increase in the odds ratio for Graves' disease, Hashimoto's thyroiditis, hypothyroidism and other unspecified thyroid disorders. This meta-analysis provided insight into thyroid diseases in patients with LS, revealing a significant association with an increased risk of autoimmune thyroid disease and hyperthyroidism. Further research is needed to clarify this association and enhance the comprehensive care of patients with LS.

Background/Objectives: Psoriasis is a chronic immune-mediated skin disease associated with several metabolic comorbidities. Metabolic dysfunction-associated steatotic liver disease (MASLD) is also linked to psoriasis, but evidence regarding the severity of this association remains inconclusive. This meta-analysis aimed to investigate the relationship between MASLD and varying severities of psoriasis. Methods: We conducted an extensive search of four databases, MEDLINE, EMBASE, OSF, and ClinicalTrials.gov to identify relevant published articles assessing the risk of prevalent MASLD in patients with moderate-to-severe psoriasis up to April 2024. Effect estimates from each included study were combined together to calculate a pooled effect estimate for the meta-analysis using the generic inverse variance method of DerSimonian and Laird. Results: This meta-analysis included eight studies with a total of 109,806 participants. A 4.01-fold increased risk of prevalent MASLD was observed in patients with moderate-to-severe psoriasis compared to those without psoriasis (95% CI: 2.17, 7.77; I² = 67%, p < 0.0001). The evidence supporting this outcome had low certainty. Conclusions: An incremental trend of MASLD was observed in patients with moderate-to-severe psoriasis. Routine screening for MASLD should be emphasized in this population.

INPLASY202510068 The Risk of Metabolic Dysfunction-Associated Steatotic Liver Disease in Moderate-to-Severe Psoriasis: A systematic review and meta-analysis Psoriasis; meta-analysis; liver disease;…

Background/Objective: Lichen sclerosus is a chronic inflammatory skin disease that affects people of all ages and sexes. Evidence of cardiovascular risk factors in lichen sclerosus has been continuously reported; however, the definitive association remains inconclusive. This meta-analysis aimed to summarize the association between cardiovascular risk factors and lichen sclerosus. Methods: Electronic databases, including MEDLINE and EMBASE, were systematically searched from inception to May 2024 to identify the literature reporting the association between cardiovascular risk factors and lichen sclerosus. A random-effects model was used for the meta-analysis. Results: We included 16 eligible studies: nine case–control studies, six retrospective cohort studies, and one cross-sectional study. A total of 432,457 participants were included. Lichen sclerosus was significantly associated with type 2 diabetes mellitus with an odds ratio of 2.07 (95% CI: 1.21–3.52). Although not statistically significant, a trend of increasing risk in hypertension, dyslipidemia, obesity, and metabolic syndrome was observed among lichen sclerosus patients, with odds ratios of 1.56 (95% CI: 0.90–2.70), 1.44 (95% CI: 0.94–2.23), 5.84 (95% CI: 0.37–92.27), and 1.36 (95% CI: 0.52–3.54), respectively. Conclusions: Lichen sclerosus was associated with diabetes mellitus and potentially correlated with hypertension, dyslipidemia, obesity, and metabolic syndrome. Population-based prospective observational studies are required to further elucidate these findings and assess the impact of these associations.

Background: Penile skin inversion vaginoplasty (PIV) and sigmoid colon vaginoplasty (SCV) are both regarded as surgical options for gender reassignment surgery (GRS) to improve quality of life (QoL) in male-to-female (MTF) individuals. As no studies have compared the QoL between PIV and SCV techniques, this study aimed to evaluate the differences in QoL among MTF individuals who received PIV and SCV. Methods: A cross-sectional study was conducted on patients who underwent GRS using PIV and SCV techniques at King Chulalongkorn Memorial Hospital (KCMH) from January 2002 to December 2022. The calibrated Thai version of Short-Form 36-Question Health Survey version 2 (SF-36v2) was used to assess QoL across eight health domains and to compare QoL between two surgical techniques. Results: Of the 278 eligible MTF patients, who received GRS from 2002 to 2022, 57 completed the questionnaires; 37 and 20 MTF patients underwent PIV and SCV, respectively. Statistically significant difference was found in the Mental Component Summary (p-value = 0.02) of postoperative QoL between the two groups. SCV statistically outperformed PIV in seven out of eight domains. Conclusion: In terms of QoL, MTF who underwent SCV showed better achievement than those who underwent PIV in most of the domains. Due to limitations of this study, further studies on a larger scale are needed to confirm the findings and compare other aspects of the surgical techniques. Level of Evidence: Level III, Therapeutic.

Chronic Kidney disease (CKD) is an important yet under-recognized contributor to morbidity and mortality globally. Machine-learning (ML) based decision support tools have been developed across many aspects of CKD care. Notably, algorithms developed in the prediction and diagnosis of CKD development and progression may help to facilitate early disease prevention, assist with early planning of renal replacement therapy, and offer potential clinical and economic benefits to patients and health systems. Clinical implementation can be affected by the uncertainty surrounding the methodological rigor and performance of ML-based models. This systematic review aims to evaluate the application of prognostic and diagnostic ML tools in CKD development and progression. The protocol has been prepared using the Preferred Items for Systematic Review and Meta-analysis Protocols (PRISMA-P) guidelines. The systematic review protocol for CKD prediction and diagnosis have been registered with the International Prospective Register of Systematic Reviews (PROSPERO) (CRD42022356704, CRD42022372378). A systematic search will be undertaken of PubMed, Embase, the Cochrane Central Register of Controlled Trials (CENTRAL), the Web of Science, and the IEEE Xplore digital library. Studies in which ML has been applied to predict and diagnose CKD development and progression will be included. The primary outcome will be the comparison of the performance of ML-based models with non-ML-based models. Secondary analysis will consist of model use cases, model construct, and model reporting quality. This systematic review will offer valuable insight into the performance and reporting quality of ML-based models in CKD diagnosis and prediction. This will inform clinicians and technical specialists of the current development of ML in CKD care, as well as direct future model development and standardization.

Chronic Kidney disease (CKD) is an important yet under-recognized contributor to morbidity and mortality globally. Machine-learning (ML) based decision support tools have been developed across many aspects of CKD care. Notably, algorithms developed in the prediction and diagnosis of CKD development and progression may help to facilitate early disease prevention, assist with early planning of renal replacement therapy, and offer potential clinical and economic benefits to patients and health systems. Clinical implementation can be affected by the uncertainty surrounding the methodological rigor and performance of ML-based models. This systematic review aims to evaluate the application of prognostic and diagnostic ML tools in CKD development and progression. The protocol has been prepared using the Preferred Items for Systematic Review and Meta-analysis Protocols (PRISMA-P) guidelines. The systematic review protocol for CKD prediction and diagnosis have been registered with the International Prospective Register of Systematic Reviews (PROSPERO) (CRD42022356704, CRD42022372378). A systematic search will be undertaken of PubMed, Embase, the Cochrane Central Register of Controlled Trials (CENTRAL), the Web of Science, and the IEEE Xplore digital library. Studies in which ML has been applied to predict and diagnose CKD development and progression will be included. The primary outcome will be the comparison of the performance of ML-based models with non-ML-based models. Secondary analysis will consist of model use cases, model construct, and model reporting quality. This systematic review will offer valuable insight into the performance and reporting quality of ML-based models in CKD diagnosis and prediction. This will inform clinicians and technical specialists of the current development of ML in CKD care, as well as direct future model development and standardization.

Introduction: Fecal microbiota transplantation (FMT) has been proposed as a potential treatment for irritable bowel syndrome (IBS); however, the consensus regarding its efficacy and safety is limited.Materials and Methods: We performed a systematic search of the literature using PubMed, EMBASE, Ovid MEDLINE, and Cochrane. Meta-analyses were conducted in relative risk (RR) or standard mean difference (SMD) using 95% confidence intervals (CI). Cochrane risk-of-bias 2 tool (RoB2) was employed to evaluate the study quality.Result: Of 2,589 potential records, 7 studies with 9 cohorts involving 505 participants were included. Meta-analyses showed no significant difference in the short-term (12 weeks) and long-term (12 months) global improvement of IBS symptoms of FMT vs. placebo (RR 0.63, 95% CI 0.39–1.00 and RR 0.88, 95% CI 0.53–1.45, respectively). There were statistically significant differences of short-term IBS-SSS improvement (SMD –0.58, 95% CI –1.09 to –0.88) and short-term IBS-QoL improvement (SMD 0.67, 95% CI 0.43–0.91). Eight from 9 studies (88.9%) had a low risk of bias. The subgroup analysis revealed the short-term global symptoms improvement in studies with low-risk of bias (RR 0.53, 95% CI 0.35–0.81), studies with well-defined donors (RR 0.31, 95% CI 0.14–0.72), and studies with FMT using colonoscopy (RR 0.66, 95% CI 0.47–0.92). Major FMT adverse events are transient and rapidly self-limiting.Conclusion: FMT significantly improved IBS-SSS and IBS-QoL in the short-term period in IBS patients. However, global symptom improvement showed no significance. Well-defined donors and appropriate fecal administration routes appear to be important factors for the successful outcomes of FMT in IBS.Systematic review registration: [www.crd.york.ac.uk/prospero], identifier [CRD42021246101].