Chengeng Yang
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Chengeng Yang has a total of 12 co-authors. Here are the top co-authors by number of shared publications:
- Amy Daniel Ulumben
Gordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
1 shared publication - Brian D. Cortese
Department of Urology, Vanderbilt University Medical Center, Nashville, TN
1 shared publication - Georges El Fakhri
Yale University
1 shared publication - Hak Soo Choi
Bioengineering and Nanomedicine Program, ADA Forsyth Institute, 100 Chestnut St, Somerville, MA 02143, USA; School of Materials Science, Japan Advanced Institute of Science and Technology, 1-1 Asahidai, Nomi 923-1292, Ishikawa, Japan
1 shared publication - Hushan Yuan
ORCID http://orcid.org
1 shared publication - Marc D. Normandin
Yale University New Haven Connecticut USA
1 shared publication
Latest Publications
- Open Access
- 24 November 2021
- Published by MDPI AG in Biomolecules
- Vol. 11 (12) , 1753
Near-Infrared Fluorescence Imaging of Carotid Plaques in an Atherosclerotic Murine Model
Successful imaging of atherosclerosis, one of the leading global causes of death, is crucial for diagnosis and intervention. Near-infrared fluorescence (NIRF) imaging has been widely adopted along with multimodal/hybrid imaging systems for plaque detection. We evaluate two macrophage-targeting fluorescent tracers for NIRF imaging (TLR4-ZW800-1C and Feraheme-Alexa Fluor 750) in an atherosclerotic murine cohort, where the left carotid artery (LCA) is ligated to cause stenosis, and the right carotid artery (RCA) is used as a control. Imaging performed on dissected tissues revealed that both tracers had high uptake in the diseased vessel compared to the control, which was readily visible even at short exposure times. In addition, ZW800-1C’s renal clearance ability and Feraheme’s FDA approval puts these two tracers in line with other NIRF tracers such as ICG. Continued investigation with these tracers using intravascular NIRF imaging and larger animal models is warranted for clinical translation.
- 24 November 2021
- Published by MDPI AG in Biomolecules
- Vol. 11 (12) , 1753
Open AccessNear-Infrared Fluorescence Imaging of Carotid Plaques in an Atherosclerotic Murine Model
Successful imaging of atherosclerosis, one of the leading global causes of death, is crucial for diagnosis and intervention. Near-infrared fluorescence (NIRF) imaging has been widely adopted along with multimodal/hybrid imaging systems for plaque detection. We evaluate two macrophage-targeting fluorescent tracers for NIRF imaging (TLR4-ZW800-1C and Feraheme-Alexa Fluor 750) in an atherosclerotic murine cohort, where the left carotid artery (LCA) is ligated to cause stenosis, and the right carotid artery (RCA) is used as a control. Imaging performed on dissected tissues revealed that both tracers had high uptake in the diseased vessel compared to the control, which was readily visible even at short exposure times. In addition, ZW800-1C’s renal clearance ability and Feraheme’s FDA approval puts these two tracers in line with other NIRF tracers such as ICG. Continued investigation with these tracers using intravascular NIRF imaging and larger animal models is warranted for clinical translation.