Austin B. Ambur

Article Tumid lupus masquerading as rosacea was published on March 5, 2024 in the journal Journal of Osteopathic Medicine (volume 0, issue 0).

Article Traumatic tattooing: case description and a comprehensive review of the therapeutic management was published on January 18, 2024 in the journal Journal of Osteopathic Medicine (volume 0, issue 0).

Graham–Little–Piccardi–Lasseur syndrome (GLPLS) is characterized by diffuse alopecia and a lichenoid follicular eruption affecting the scalp, eyebrows, and intertriginous regions. It is considered a variant of lichen planopilaris. The condition often begins as hyperkeratotic papules on the trunk and extremities followed by the development of alopecia. Several subtypes of lichen planus have been associated with a photodistriubuted eruption including lichenoid drug reactions, actinic lichen planus, and lichen planus pigmentosus; however, there are no reported cases associated with GLPLS. We herein report the first case of GLPLS displaying a photodistributed lichenoid eruption to expand upon the differential diagnosis of photoaggravated conditions. We also use this case to review the pathophysiology and therapeutic modalities to manage GLPLS.

Article Subcutaneous Sweet’s syndrome: a rare subtype of acute febrile neutrophilic dermatosis was published on August 29, 2022 in the journal Journal of Osteopathic Medicine (volume 0, issue 0).

Article Annular bullous lesions in a child from Uganda: chronic bullous disease of childhood was published on November 2, 2022 in the journal Journal of Osteopathic Medicine (volume 0, issue 0).

Article Isolated nevus unius lateralis in a patient from Uganda was published on September 15, 2022 in the journal Journal of Osteopathic Medicine (volume 0, issue 0).

Article Leukoderma with perifollicular sparing: a diagnostic clue of cutaneous onchocerciasis was published on August 30, 2022 in the journal Journal of Osteopathic Medicine (volume 0, issue 0).

Darier (Darier‐White) disease (DD) is an autosomal dominant skin disorder caused by pathogenic mutations in the ATP2A2 gene which encodes a calcium ATPase in the sarco‐endoplasmic reticulum (SERCA2). Defects in the SERCA2 protein lead to an impairment of cellular calcium homeostasis, which in turn, triggers cell death pathways. There is a high prevalence of neuropsychiatric disorders in patients affected by this condition, namely intellectual disability, bipolar disorder, schizophrenia, and suicidality. Though these associations have been well‐documented over the years, little has been discussed or investigated regarding the pathophysiological mechanisms. The goal of this article is to review the literature related to the most commonly associated neuropsychiatric disorders found in patients with DD, highlight the pathophysiological mechanisms underlying each condition, and examine potential interventions that may be of interest for future development. A literature search was performed using PubMed to access and review relevant articles published in the last 40 years. Keywords searched included Darier disease neuropsychiatric, Darier disease pathophysiology, SERCA2 central nervous system, SERCA 2 skin, ATP2A2 central nervous system, ATP2A2 skin, sphingosine‐1‐phosphate signalling skin, sphingosine‐1‐phosphate signalling central nervous system, P2X7 receptor skin, and P2X7 receptor central nervous system. Our search resulted in 2692 articles, of which 61 articles were ultimately included in this review.

Article Hermansky-Pudlak syndrome was published on June 8, 2022 in the journal Journal of Osteopathic Medicine (volume 0, issue 0).