Jae-Hun Jung
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Jae-Hun Jung has a total of 9 co-authors. Here are the top co-authors by number of shared publications:
- Bo-Seul Song
Department of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Goyang-si 10408, Korea
1 shared publication - Dong Hoon Shin
Research Institute, National Cancer Center, Goyang-si, Republic of Korea
1 shared publication - Hye Jin You
Cancer Microenvironment Branch, Division of Cancer Biology, Research Institute, National Cancer Center, Goyang 10408, Republic of Korea
1 shared publication - Jae Young Joung
Department of Urology, Urological Cancer Center, National Cancer Center, Goyang 10408, Republic of Korea
1 shared publication - Jae-Kyung Myung
Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
1 shared publication - Jong-Kwang Kim
Bioinformatics Analysis Team, Research Core Center, Research Institute, National Cancer Center, Goyang, 10408, Gyeonggi-do, Republic of Korea
1 shared publication
Latest Publications
- Open Access
- 10 December 2021
- Published by MDPI AG in Biomedicines
- Vol. 9 (12) , 1877
Rapid Androgen-Responsive Proteome Is Involved in Prostate Cancer Progression
Androgen exerts its functions by binding with an androgen receptor (AR). It can activate many signaling pathways that are important to the progression of castration-resistant prostate cancer (CRPC). Here, we characterized the rapid proteomic changes seen at 5, 15, 30, and 60 min after the androgen treatment of VCaP cells via the tandem mass tag (TMT) labeling strategy. A total of 5529 proteins were successfully identified and quantified. Dynamic time profiling of protein expression patterns allowed us to identify five protein clusters involved in various stages of androgen-initiated signal transmission and processing. More details of protein functions and localization patterns, and our elucidation of an AR-interacting protein network, were obtained. Finally, we validated the expression level of AR-regulated proteins known to be significantly regulated in CRPC patients using the mouse xenograft model and patient samples. Our work offers a systematic analysis of the rapid proteomic changes induced by androgen and provides a global view of the molecular mechanisms underlying CRPC progression.
- 10 December 2021
- Published by MDPI AG in Biomedicines
- Vol. 9 (12) , 1877
Open AccessRapid Androgen-Responsive Proteome Is Involved in Prostate Cancer Progression
Androgen exerts its functions by binding with an androgen receptor (AR). It can activate many signaling pathways that are important to the progression of castration-resistant prostate cancer (CRPC). Here, we characterized the rapid proteomic changes seen at 5, 15, 30, and 60 min after the androgen treatment of VCaP cells via the tandem mass tag (TMT) labeling strategy. A total of 5529 proteins were successfully identified and quantified. Dynamic time profiling of protein expression patterns allowed us to identify five protein clusters involved in various stages of androgen-initiated signal transmission and processing. More details of protein functions and localization patterns, and our elucidation of an AR-interacting protein network, were obtained. Finally, we validated the expression level of AR-regulated proteins known to be significantly regulated in CRPC patients using the mouse xenograft model and patient samples. Our work offers a systematic analysis of the rapid proteomic changes induced by androgen and provides a global view of the molecular mechanisms underlying CRPC progression.