Irina I. Glazko

Background. Androgenetic alopecia (AGA) in young individuals is a psychodermatological risk rather than a purely aesthetic issue. Hair is a crucial element of non-verbal communication and socialization. The subjective distress is deeply mediated by premorbid personality vulnerability. Purpose. To thoroughly analyze the structure of constitutional character accentuations in young adults (17–35 years) with verified AGA to build an integrated management model. Materials and methods. Fifty patients (56.0% females, 44.0% males) with verified AGA were examined. A. Lichko's Personality Diagnostic Questionnaire (PDQ) was utilized with a cumulative point analysis across the cohort. Statistical calculations incorporated Wilson's 95% confidence intervals (95% CI). Results. The structure of the personality profile demonstrated a distinct prevalence of psychasthenic (626 points) and hyperthymic (614 points) response types. Astheno-neurotic (428 points) and unstable (406 points) components were the least pronounced. Bipolar maladaptation patterns were discovered: ranging from "anxious symptom control" to lowered compliance due to underestimation of disease progression. Conclusions. Psychological screening must be embedded into primary dermatological paths. The heterogeneity of leading character traits requires a differentiated approach to patient communication to enhance long-term compliance and prevent dysmorphophobic reactions.

Introduction. Chronic skin ulcers, including radiation-induced ones, are associated with impaired regeneration, chronic inflammation and a high risk of complications, which requires new approaches to treatment due to the low efficiency of traditional methods. Modern methods of regenerative medicine, such as application of biopolymer coatings and exosomal drugs, promote tissue restoration by improving the microenvironment, stimulating cellular activity and modulating inflammation.Aim. To develop a model of chronic radiation-induced skin injury and assess the therapeutic efficacy of monotherapy with medical device SPHERO®gel, exosome therapy (manufactured by New Medicine Stem Cell Clinic), and their combination in laboratory animals.Materials and methods. The study involved 48 male Wistar rats subjected to fractionated X-ray irradiation (5 × 10 Gy), mechanical skin injury, and persistent inflammation induced by lipopolysaccharide (LPS) injection. Animals were randomized into four groups: control, SPHERO®gel, exosomes (manufactured by New Medicine Stem Cell Clinic), and combined treatment. Therapy was applied for 28 days. Wound healing efficacy was evaluated using ulcer area morphometry (ImageJ) and histological examination.Results and discussion. Both SPHERO®gel and exosome (New Medicine Stem Cell Clinic) therapy significantly enhanced tissue repair, reduced fibrosis and inflammation. The combined therapy resulted in complete epithelialization in 75 % of animals, normalized angiogenesis, and restored dermal architecture.Conclusion. The combination of SPHERO®gel and exosomes (manufactured by New Medicine Stem Cell Clinic) demonstrates a synergistic effect in the treatment of chronic radiation-induced ulcers and holds promise for clinical application in regenerative and restorative medicine.

Despite advancements in modern reconstructive surgery, preventing the formation of thick scar tissue that impairs limb function or causes cosmetic defects remains a critical challenge. Equally important is the effective correction of existing scars to optimize both functional and aesthetic outcomes. Severe functional impairment of the upper limbs can result in disability. A combination of surgical and nonsurgical interventions is essential to enhance functionality while minimizing the risk of scar recurrence. Platelet-rich plasma injections, stem cell therapy, adipose tissue transplantation, and a combination of negative pressure wound therapy (NPWT) with traditional flap reconstruction and other transplantation methods are gaining popularity in modern reconstructive surgery. NPWT plays a crucial role in preparing the wound bed for subsequent tissue reconstruction and serves as an effective alternative to traditional dressings. The vacuum created over the wound after closure with a skin autograft helps prevent inflammation at the graft base, reduces excessive granulation tissue formation, and minimizes the risk of rough scar development in the long term. The mechanisms of formation of hypertrophic scar and keloids have not yet been completely understood. However, research indicates that bone marrow-derived cells, including fibrocytes and keratinocyte-like cells, contribute to the inflammatory cell infiltrate during wound healing, and can play a role in cutaneous fibrosis, especially in cases of impaired healing. Several pathophysiological and biochemical processes involved in the repair of extensive and deep wounds have been established. Additionally, the role of keratinocytes within hair follicle bulbs in promoting epithelialization of post-burn wound surfaces, particularly in areas with preserved skin appendages, has been recognized. Studies indicate that stromal-vascular fraction of adipose tissue plays a positive role in various stages of wound healing, including keloid and hypertrophic scar formation. Adipose-derived stem cells can be used in combination with hydrogel. The hydrogel base of dressings maintains a moist environment in both burn wounds and wound surfaces following tangential or radical excision of burn scab. This promotes faster wound healing, reduces the risk of scar hyperplasia, and enhances the sustained release and effectiveness of medications applied to the hydrogel base. Prompt surgical intervention, including early excision and grafting, along with modern treatment methods in the early postoperative period for deep burns, can significantly reduce the risk of hypertrophic and keloid scar formation.

Iatrogeny — undesirable effects of medical interventions, which can be caused by errors in the choice of therapy, insufficient qualification of specialist and incorrect compliance with technic of procedures. The increasing popularity and availability of cosmetological treatments are accompanied by a growth in the number of iatrogenic complications. Iatrogenic complications in cosmetology have a significant impact on patients’ psychological state. Physical discomfort associated with complications is often followed by psychological problems: reduced self-assessment, feelings of self-doubt, depressive disorders, social isolation. Post-inflammatory hyperpigmentation (PIH) is a common form of iatrogenic hypermelanosis that occurs after cosmetological procedures. Treatment of PIH requires a comprehensive approach, including the use of photoprotectors and topical agents. The article lists the pathogenetic aspects of PIH, as well as provides external correction agents such as hydroquinone, azelaic, tranexamic, kojic acids, retinoids and thiamidol. Thiamidol is a highly selective human tyrosinase inhibitor, the application of which reduces the risk of PIH development. The presented clinical cases confirm that the irrational use of hardware technologies and the lack of a comprehensive approach affecting all the parts of melanogenesis contribute to the development of iatrogenic complications. Effective application of safe methods, which contribute to the elimination of iatrogenic post-inflammatory hypermelanosis, is an urgent task of improving the quality of life of patients.

BACKGROUND: Acne vulgaris (acne vulgaris) is an urgent interdisciplinary problem. Analyzing modern scientific data on the development of acne vulgaris, it is necessary to focus on the role of inflammation that accompanies dermatosis at all its stages of development, sometimes preceding the formation of clinical symptoms. Prolonged chronic recurrent course, difficulties in choosing the correct therapy tactics, sometimes unreasonable medical interventions, exacerbation, improper skin care lead to the formation of a number of complications. AIMS: To optimize and improve the effectiveness of therapy in patients with moderate and severe degrees acne using isotretinoin and the combined innovative gel Contractubex Anti-Red. MATERIALS AND METHODS: The study included 60 patients aged 18 to 45 years with moderate to severe acne. Isotretinoin was prescribed in standard dosages. To study the effect of Сontraktubex Anti-Red on the dynamics of post-acne, patients with atrophic post-acne scars were divided into 3 subgroups, depending on the regimen of drug use. RESULTS: Almost complete relief of the inflammatory process, regression of elements was noted 12 months after the use of complex therapy, the value of the dermanologic index of acne (DIA) index was more than 70% noted in 62% of patients, significant improvement in 38%. The severity of post-acne scars on the SCAR-S scale changed significantly during treatment and in 53.3% this indicator was 1. The Cadi index decreased by 70% compared to the baseline. CONCLUSION: Good cosmetic effect, safety, absence of side effects, comfort and ease of use make it possible to recommend Contractubex Anti-Red together with basic acne therapy.