Ramón Martínez-Pacheco
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Ramón Martínez-Pacheco has a total of 6 co-authors. Here are the top co-authors by number of shared publications:
Consuelo Souto
Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela, Spain
2 shared publicationsAlberto Rodríguez
Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela, Spain
1 shared publication- Angel Concheiro
I+D Farma Group (GI-1645), Department of Pharmacology, Pharmacy and Pharmaceutical Technology, Facultad de Farmacia and Instituto de Materiales (iMATUS), Universidade de Santiago de Compostela, Santiago de Compostela 15782, Spain; Health Research Institute of Santiago de Compostela (IDIS), Complexo Hospitalario Universitario de Santiago de Compostela, Travesa da Choupana s/n., 15706 Santiago de Compostela, Spain
1 shared publication - José Luis Gómez Amoza
Department of Pharmacology, Pharmacy and Pharmaceutical Technology, University of Santiago de Compostela, Santiago de Compostela 15782, Spain
1 shared publication Marta Casalderrey
Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Santiago de Compostela, Spain
1 shared publicationSilvia Parajes
Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela, Spain
1 shared publication
Latest Publications
- 30 September 2005
- Published by Elsevier in European Journal of Pharmaceutics and Biopharmaceutics
- Vol. 61 (1-2) , 94-99
A comparative study of the utility of two superdisintegrants in microcrystalline cellulose pellets prepared by extrusion–spheronization
- 30 September 2005
- Published by Elsevier in European Journal of Pharmaceutics and Biopharmaceutics
- Vol. 61 (1-2) , 94-99
A comparative study of the utility of two superdisintegrants in microcrystalline cellulose pellets prepared by extrusion–spheronization
- Open Access
- 1 January 2004
- Published by Pharmaceutical Society of Japan in Chemical and Pharmaceutical Bulletin
- Vol. 52 (4) , 398-401
A Comparison of Drug Loading Capacity of Cellactose with Two ad hoc Processed Lactose-Cellulose Direct Compression Excipients
This study compares the drug loading capacity of Cellactose and two excipients of similar composition and similar particle size, prepared by dry granulation and extrusion-spheronization respectively. The drugs evaluated were acetaminophen and furosemide. Acetaminophen did not significantly affect the flow properties of any of the excipients, whereas furosemide markedly worsened flow properties, eliminating the differences initially existing among the three excipients. For both drugs, tablet mechanical properties were clearly better with Cellactose than with the other excipients. Acetaminophen dissolution rate was very similar regardless of the excipient used, but furosemide dissolution rate was lower from Cellactose tablets than from tablets prepared with the other excipients. This important difference is discussed in terms of micropore structure, specific surface area, and wettability of tablets, and is attributable to the special structure of Cellactose particles.
- 1 January 2004
- Published by Pharmaceutical Society of Japan in Chemical and Pharmaceutical Bulletin
- Vol. 52 (4) , 398-401
Open AccessA Comparison of Drug Loading Capacity of Cellactose with Two ad hoc Processed Lactose-Cellulose Direct Compression Excipients
This study compares the drug loading capacity of Cellactose and two excipients of similar composition and similar particle size, prepared by dry granulation and extrusion-spheronization respectively. The drugs evaluated were acetaminophen and furosemide. Acetaminophen did not significantly affect the flow properties of any of the excipients, whereas furosemide markedly worsened flow properties, eliminating the differences initially existing among the three excipients. For both drugs, tablet mechanical properties were clearly better with Cellactose than with the other excipients. Acetaminophen dissolution rate was very similar regardless of the excipient used, but furosemide dissolution rate was lower from Cellactose tablets than from tablets prepared with the other excipients. This important difference is discussed in terms of micropore structure, specific surface area, and wettability of tablets, and is attributable to the special structure of Cellactose particles.