Hyemi Lee
Research Subjects
Hyemi Lee has a total of 5 co-authors. Here are the top co-authors by number of shared publications:
- Hakwon Kim
Department of Applied Chemistry, Global Center for Pharmaceutical Ingredient Materials Kyung Hee University Yongin Republic of Korea
1 shared publication - Joon Kwang Lee
Process Research, Boryung R&D Institute, Ansan 15425, Korea
1 shared publication - Ok Kyoung Choi
Department of Applied Chemistry and Global Center for Pharmaceutical Ingredient Materials, Kyung Hee University, Yongin 17410, Korea
1 shared publication - Tae Hoon Lee
Department of Applied Chemistry, Kyung Hee University, Yongin 17410, Republic of Korea
1 shared publication - Yong Ho Sun
Process Research, Boryung R&D Institute, Ansan 15425, Korea
1 shared publication
Latest Publications
- Open Access
- 4 January 2022
- Published by MDPI AG in Pharmaceuticals
- Vol. 15 (1) , 64
Synthesis of Novel (S)-3-(1-Aminoethyl)-8-pyrimidinyl-2-phenylisoquinolin-1(2H)-ones by Suzuki–Miyaura Coupling and Their Cell Toxicity Activities
A series of (S)-3-(1-aminoethyl)-8-pyrimidinyl-2-phenylisoquinoline-1(2H)-ones 3a–3k was synthesized in 40–98% yield through Suzuki–Miyaura coupling using Pd(PPh3)2Cl2, Sphos, and K2CO3 in THF/H2O mixed solvent. All newly synthesized compounds were evaluated for cell viability (IC50) against MDA-MB-231, HeLa, and HepG2 cells. The antitumor activities of 3a–3k were improved when various pyrimidine motifs were introduced at position C-8 of the isoquinolinone ring.
- 4 January 2022
- Published by MDPI AG in Pharmaceuticals
- Vol. 15 (1) , 64
Open AccessSynthesis of Novel (S)-3-(1-Aminoethyl)-8-pyrimidinyl-2-phenylisoquinolin-1(2H)-ones by Suzuki–Miyaura Coupling and Their Cell Toxicity Activities
A series of (S)-3-(1-aminoethyl)-8-pyrimidinyl-2-phenylisoquinoline-1(2H)-ones 3a–3k was synthesized in 40–98% yield through Suzuki–Miyaura coupling using Pd(PPh3)2Cl2, Sphos, and K2CO3 in THF/H2O mixed solvent. All newly synthesized compounds were evaluated for cell viability (IC50) against MDA-MB-231, HeLa, and HepG2 cells. The antitumor activities of 3a–3k were improved when various pyrimidine motifs were introduced at position C-8 of the isoquinolinone ring.