Rex Jeya Rajkumar Samdavid Thanapaul
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Rex Jeya Rajkumar Samdavid Thanapaul has a total of 5 co-authors. Here are the top co-authors by number of shared publications:
- Daniel Sam Roh
Department of Surgery, Division of Plastic and Reconstructive Surgery Boston University Chobanian & Avedisian School of Medicine Boston Massachusetts USA
3 shared publications Mosae Selvakumar Paulraj
Asian University for Women
2 shared publications- Jack Crouch
Division of Plastic and Reconstructive Surgery, Department of Surgery, Boston University School of Medicine, 609 Albany St., Boston, MA, 02118, USA
1 shared publication - Maria Shvedova
BUMC Center for Aging Research, Division of Plastic and Reconstructive Surgery, Department of Surgery, Boston University School of Medicine
1 shared publication - Vladimir A. Botchkarev
Department of Dermatology, Boston University School of Medicine
1 shared publication
Latest Publications
- Open Access
Epigenetic Regulation of Cellular Senescence
Senescence is a complex cellular stress response that abolishes proliferative capacity and generates a unique secretory pattern that is implicated in organismal aging and age-related disease. How a cell transitions to a senescent state is multifactorial and often requires transcriptional regulation of multiple genes. Epigenetic alterations to DNA and chromatin are powerful regulators of genome architecture and gene expression, and they play a crucial role in mediating the induction and maintenance of senescence. This review will highlight the changes in chromatin, DNA methylation, and histone alterations that establish and maintain cellular senescence, alongside the specific epigenetic regulation of the senescence-associated secretory phenotype (SASP).
Open AccessEpigenetic Regulation of Cellular Senescence
Senescence is a complex cellular stress response that abolishes proliferative capacity and generates a unique secretory pattern that is implicated in organismal aging and age-related disease. How a cell transitions to a senescent state is multifactorial and often requires transcriptional regulation of multiple genes. Epigenetic alterations to DNA and chromatin are powerful regulators of genome architecture and gene expression, and they play a crucial role in mediating the induction and maintenance of senescence. This review will highlight the changes in chromatin, DNA methylation, and histone alterations that establish and maintain cellular senescence, alongside the specific epigenetic regulation of the senescence-associated secretory phenotype (SASP).
- 1 January 2021
- Published by Springer Nature
- p. 1-25
Nanobiotechnology-Based Anti-aging Products