Alexandra Wolff
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Alexandra Wolff has a total of 4 co-authors. Here are the top co-authors by number of shared publications:
- Arne Christian Rodloff
Institute of Medical Microbiology and Epidemiology of Infectious Diseases, University Hospital of Leipzig, Leipzig, Germany
1 shared publication - Catalina-Suzana Stingu
Institute for Medical Microbiology and Virology, University of Leipzig Medical Center, 04103 Leipzig, Germany
1 shared publication - Paul Vielkind
Institute for Medical Microbiology and Virology, University Hospital, University of Leipzig, 04103 Leipzig, Germany
1 shared publication - Toralf Borgmann
Institute for Medical Microbiology and Virology, University Hospital, University of Leipzig, 04103 Leipzig, Germany
1 shared publication
Latest Publications
- Open Access
- 7 January 2022
- Published by MDPI AG in Microorganisms
- Vol. 10 (1) , 125
Antimicrobial Susceptibility of Clinical Oral Isolates of Actinomyces spp.
Actinomyces species play an important role in the pathogenesis of oral diseases and infections. Susceptibility testing is not always routinely performed, and one may oversee a shift in resistance patterns. The aim of the study was to analyze the antimicrobial susceptibility of 100 well-identified clinical oral isolates of Actinomyces spp. against eight selected antimicrobial agents using the agar dilution (AD) and E-Test (ET) methods. We observed no to low resistance against penicillin, ampicillin-sulbactam, meropenem, clindamycin, linezolid and tigecycline (0–2% ET, 0% AD) but high levels of resistance to moxifloxacin (93% ET, 87% AD) and daptomycin (83% ET, 95% AD). The essential agreement of the two methods was very good for benzylpenicillin (EA 95%) and meropenem (EA 92%). The ET method was reliable for correctly categorizing susceptibility, in comparison with the reference method agar dilution, except for daptomycin (categorical agreement 87%). Penicillin is still the first-choice antibiotic for therapy of diseases caused by Actinomyces spp.
- 7 January 2022
- Published by MDPI AG in Microorganisms
- Vol. 10 (1) , 125
Open AccessAntimicrobial Susceptibility of Clinical Oral Isolates of Actinomyces spp.
Actinomyces species play an important role in the pathogenesis of oral diseases and infections. Susceptibility testing is not always routinely performed, and one may oversee a shift in resistance patterns. The aim of the study was to analyze the antimicrobial susceptibility of 100 well-identified clinical oral isolates of Actinomyces spp. against eight selected antimicrobial agents using the agar dilution (AD) and E-Test (ET) methods. We observed no to low resistance against penicillin, ampicillin-sulbactam, meropenem, clindamycin, linezolid and tigecycline (0–2% ET, 0% AD) but high levels of resistance to moxifloxacin (93% ET, 87% AD) and daptomycin (83% ET, 95% AD). The essential agreement of the two methods was very good for benzylpenicillin (EA 95%) and meropenem (EA 92%). The ET method was reliable for correctly categorizing susceptibility, in comparison with the reference method agar dilution, except for daptomycin (categorical agreement 87%). Penicillin is still the first-choice antibiotic for therapy of diseases caused by Actinomyces spp.