Zsolt Szűcs
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Zsolt Szűcs has a total of 7 co-authors. Here are the top co-authors by number of shared publications:
- Anikó Borbás
Department of Pharmaceutical Chemistry, University of Debrecen, Egyetem tér 1, H-4032 Debrecen, Hungary
1 shared publication - Eszter Ostorházi
Department of Medical Microbiology, Semmelweis University, Budapest, Hungary
1 shared publication - Gyula Batta
Department of Organic Chemistry, University of Debrecen, H-4032 Debrecen, Hungary
1 shared publication - Ilona Bereczki
Department of Pharmaceutical Chemistry, University of Debrecen, Debrecen, Hungary
1 shared publication - Katalin E. Kövér
MTA-DE Molecular Recognition and Interaction Research Group, University of Debrecen
1 shared publication - Pál Herczegh
Department of Pharmaceutical Chemistry, University of Debrecen, Debrecen, Hungary
1 shared publication
Latest Publications
- Open Access
- 8 January 2022
- Published by MDPI AG in Pharmaceuticals
- Vol. 15 (1) , 77
The First Dimeric Derivatives of the Glycopeptide Antibiotic Teicoplanin
Various dimeric derivatives of the glycopeptide antibiotic teicoplanin were prepared with the aim of increasing the activity of the parent compound against glycopeptide-resistant bacteria, primarily vancomycin-resistant enterococci. Starting from teicoplanin, four covalent dimers were prepared in two orientations, using an α,ω-bis-isothiocyanate linker. Formation of a dimeric cobalt coordination complex of an N-terminal L-histidyl derivative of teicoplanin pseudoaglycone has been detected and its antibacterial activity evaluated. The Co(III)-induced dimerization of the histidyl derivative was demonstrated by DOSY experiments. Both the covalent and the complex dimeric derivatives showed high activity against VanA teicoplanin-resistant enterococci, but their activity against other tested bacterial strains did not exceed that of the monomeric compounds.
- 8 January 2022
- Published by MDPI AG in Pharmaceuticals
- Vol. 15 (1) , 77
Open AccessThe First Dimeric Derivatives of the Glycopeptide Antibiotic Teicoplanin
Various dimeric derivatives of the glycopeptide antibiotic teicoplanin were prepared with the aim of increasing the activity of the parent compound against glycopeptide-resistant bacteria, primarily vancomycin-resistant enterococci. Starting from teicoplanin, four covalent dimers were prepared in two orientations, using an α,ω-bis-isothiocyanate linker. Formation of a dimeric cobalt coordination complex of an N-terminal L-histidyl derivative of teicoplanin pseudoaglycone has been detected and its antibacterial activity evaluated. The Co(III)-induced dimerization of the histidyl derivative was demonstrated by DOSY experiments. Both the covalent and the complex dimeric derivatives showed high activity against VanA teicoplanin-resistant enterococci, but their activity against other tested bacterial strains did not exceed that of the monomeric compounds.