Brianna L. Bourgeois
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Previous Organizations / Institutes
The organizations / institutes from the scholar's other articles in the past ten years
Research Subjects
Brianna L. Bourgeois has a total of 11 co-authors. Here are the top co-authors by number of shared publications:
- Liz Simon
Department of Physiology Louisiana State University Health Sciences Center New Orleans Louisiana USA
3 shared publications - Danielle Evé Levitt
Department of Kinesiology and Sport Management, Texas Tech University, Lubbock, TX 79409, USA
2 shared publications - Patricia E. Molina
Comprehensive Alcohol‐HIV/AIDS Research Center Louisiana State University Health Sciences Center New Orleans Louisiana USA
2 shared publications Alice Y. Yeh
Department of Physiology, Louisiana State University Health Sciences Center, New Orleans, Louisiana
1 shared publicationDanielle E. Levitt
Department of Physiology and Comprehensive Alcohol-HIV/AIDS Research Center, Louisiana State University Health Sciences Center, New Orleans, LA, 70112, USA
1 shared publicationEden M. Gallegos
Department of Physiology and Comprehensive Alcohol-HIV/AIDS Research CenterLouisiana State University Health Sciences Center, New Orleans, Louisiana, United States
1 shared publication
Latest Publications
- 1 December 2024
- Published by American Physiological Society in American Journal of Physiology-Cell Physiology
- Vol. 327 (6) , C1626-C1637
Extracellular vesicle miR-206 improves chronic binge alcohol-mediated decreased myoblast differentiation in SIV-infected female macaques
Alcohol decreases skeletal muscle myoblast differentiation into myotubes, which is associated with decreased expression of microRNA-206. We show that delivering exogenous miR-206 in plasma-derived extracellular vesicles (EVs) to myoblasts derived from alcohol-administered animals increases myotube differentiation. These results support the potential therapeutic utility of EVs in delivering muscle-enriched microRNAs to improve skeletal muscle stem cell differentiation.
- 1 December 2024
- Published by American Physiological Society in American Journal of Physiology-Cell Physiology
- Vol. 327 (6) , C1626-C1637
Extracellular vesicle miR-206 improves chronic binge alcohol-mediated decreased myoblast differentiation in SIV-infected female macaques
Alcohol decreases skeletal muscle myoblast differentiation into myotubes, which is associated with decreased expression of microRNA-206. We show that delivering exogenous miR-206 in plasma-derived extracellular vesicles (EVs) to myoblasts derived from alcohol-administered animals increases myotube differentiation. These results support the potential therapeutic utility of EVs in delivering muscle-enriched microRNAs to improve skeletal muscle stem cell differentiation.
- 1 January 2022
- Published by American Physiological Society in Physiological Genomics
- Vol. 54 (1) , 36-44
Unique circulating microRNA associations with dysglycemia in people living with HIV and alcohol use
People living with HIV (PLWH) have increased prevalence of comorbid conditions including insulin resistance and at-risk alcohol use. Circulating microRNAs (miRs) may serve as minimally invasive indicators of pathophysiological states. We aimed to identify whether alcohol modulates circulating miR associations with measures of glucose/insulin dynamics in PLWH. PLWH ( n = 96; 69.8% males) enrolled in the Alcohol & Metabolic Comorbidities in PLWH: Evidence-Driven Interventions (ALIVE-Ex) study were stratified into negative phosphatidylethanol (PEth < 8 ng/mL, n = 42) and positive PEth (PEth ≥ 8 ng/mL, n = 54) groups. An oral glucose tolerance test (OGTT) was administered, and total RNA was isolated from fasting plasma to determine absolute miR expression. Circulating miRs were selected based on their role in skeletal muscle (miR-133a and miR-206), pancreatic β-cell (miR-375), liver (miR-20a), and adipose tissue (miR-let-7b, miR-146a, and miR-221) function. Correlation and multiple regression analyses between miR expression and adiponectin, 2 h glucose, insulin, and C-peptide values were performed adjusting for body mass index (BMI) category, age, sex, and viral load. miR-133a was negatively associated with adiponectin ( P = 0.002) in the negative PEth group, and miR-20a was positively associated with 2 h glucose ( P = 0.013) in the positive PEth group. Regression analyses combining miRs demonstrated that miR-133a ( P < 0.001) and miR-221 ( P = 0.010) together predicted adiponectin in the negative PEth group. miR-20a ( P < 0.001) and miR-375 ( P = 0.002) together predicted 2 h glucose in the positive PEth group. Our results indicate that associations between miRs and measures of glucose/insulin dynamics differed between PEth groups, suggesting that the pathophysiological mechanisms contributing to altered glucose homeostasis in PLWH are potentially modulated by alcohol use.
- 1 January 2022
- Published by American Physiological Society in Physiological Genomics
- Vol. 54 (1) , 36-44
Unique circulating microRNA associations with dysglycemia in people living with HIV and alcohol use
People living with HIV (PLWH) have increased prevalence of comorbid conditions including insulin resistance and at-risk alcohol use. Circulating microRNAs (miRs) may serve as minimally invasive indicators of pathophysiological states. We aimed to identify whether alcohol modulates circulating miR associations with measures of glucose/insulin dynamics in PLWH. PLWH ( n = 96; 69.8% males) enrolled in the Alcohol & Metabolic Comorbidities in PLWH: Evidence-Driven Interventions (ALIVE-Ex) study were stratified into negative phosphatidylethanol (PEth < 8 ng/mL, n = 42) and positive PEth (PEth ≥ 8 ng/mL, n = 54) groups. An oral glucose tolerance test (OGTT) was administered, and total RNA was isolated from fasting plasma to determine absolute miR expression. Circulating miRs were selected based on their role in skeletal muscle (miR-133a and miR-206), pancreatic β-cell (miR-375), liver (miR-20a), and adipose tissue (miR-let-7b, miR-146a, and miR-221) function. Correlation and multiple regression analyses between miR expression and adiponectin, 2 h glucose, insulin, and C-peptide values were performed adjusting for body mass index (BMI) category, age, sex, and viral load. miR-133a was negatively associated with adiponectin ( P = 0.002) in the negative PEth group, and miR-20a was positively associated with 2 h glucose ( P = 0.013) in the positive PEth group. Regression analyses combining miRs demonstrated that miR-133a ( P < 0.001) and miR-221 ( P = 0.010) together predicted adiponectin in the negative PEth group. miR-20a ( P < 0.001) and miR-375 ( P = 0.002) together predicted 2 h glucose in the positive PEth group. Our results indicate that associations between miRs and measures of glucose/insulin dynamics differed between PEth groups, suggesting that the pathophysiological mechanisms contributing to altered glucose homeostasis in PLWH are potentially modulated by alcohol use.